Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Itay Sason"'
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Mutational signatures are key to understanding the processes that shape cancer genomes, yet their analysis requires relatively rich whole-genome or whole-exome mutation data. Recently, orders-of-magnitude sparser gene-panel-sequencing data h
Externí odkaz:
https://doaj.org/article/1eee8e0e684b4c5797b96c3ffaa77b66
Autor:
Yoo-Ah Kim, Damian Wojtowicz, Rebecca Sarto Basso, Itay Sason, Welles Robinson, Dorit S. Hochbaum, Mark D. M. Leiserson, Roded Sharan, Fabio Vadin, Teresa M. Przytycka
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background Studies of cancer mutations have typically focused on identifying cancer driving mutations that confer growth advantage to cancer cells. However, cancer genomes accumulate a large number of passenger somatic mutations resulting fr
Externí odkaz:
https://doaj.org/article/f01e56dc07e744279a4dd467a1377f16
Autor:
Damian Wojtowicz, Itay Sason, Xiaoqing Huang, Yoo-Ah Kim, Mark D. M. Leiserson, Teresa M. Przytycka, Roded Sharan
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Knowing the activity of the mutational processes shaping a cancer genome may provide insight into tumorigenesis and personalized therapy. It is thus important to characterize the signatures of active mutational processes in patients from the
Externí odkaz:
https://doaj.org/article/52d581e81ff7471e8af71d9aaad35546
Autor:
Itay Sason, Damian Wojtowicz, Welles Robinson, Mark D.M. Leiserson, Teresa M. Przytycka, Roded Sharan
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: The characterization of mutational processes in terms of their signatures of activity relies mostly on the assumption that mutations in a given cancer genome are independent of one another. Recently, it was discovered that certain segments o
Externí odkaz:
https://doaj.org/article/f95ea27101a0422bb3e8d2f70d46b2af
Publikováno v:
Cancers
Volume 15
Issue 5
Pages: 1601
Volume 15
Issue 5
Pages: 1601
Mutational signature analysis promises to reveal the processes that shape cancer genomes for applications in diagnosis and therapy. However, most current methods are geared toward rich mutation data that has been extracted from whole-genome or whole-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f539ca1ff4c141923dc9374e599394
Autor:
Teresa M. Przytycka, Itay Sason, Roded Sharan, Dorit S. Hochbaum, Yoo-Ah Kim, Welles Robinson, Rebecca Sarto Basso, Damian Wojtowicz, Fabio Vandin, Mark D.M. Leiserson
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-12 (2020)
Genome medicine, vol 12, iss 1
Genome Medicine
Genome medicine, vol 12, iss 1
Genome Medicine
Background Studies of cancer mutations have typically focused on identifying cancer driving mutations that confer growth advantage to cancer cells. However, cancer genomes accumulate a large number of passenger somatic mutations resulting from variou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9c6e58b48d2cd74a4853b756a22fec
http://link.springer.com/article/10.1186/s13073-020-00745-2
http://link.springer.com/article/10.1186/s13073-020-00745-2
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783030452568
RECOMB
RECOMB
Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature discovery or refitting approaches are limited to relatively rich mutation d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a83ae107979b682c09a5015c73a88e77
https://doi.org/10.1007/978-3-030-45257-5_34
https://doi.org/10.1007/978-3-030-45257-5_34
Autor:
Luna Tammer, Ofir Hameiri, Ifat Keydar, Vanessa Rachel Roy, Asaf Ashkenazy-Titelman, Noélia Custódio, Itay Sason, Ronna Shayevitch, Victoria Rodríguez-Vaello, José Rino, Galit Lev Maor, Yodfat Leader, Doha Khair, Erez Lieberman Aiden, Ran Elkon, Manuel Irimia, Roded Sharan, Yaron Shav-Tal, Maria Carmo-Fonseca, Gil Ast
Publikováno v:
Molecular Cell. 82:1021-1034.e8
How the splicing machinery defines exons or introns as the spliced unit has remained a puzzle for 30 years. Here, we demonstrate that peripheral and central regions of the nucleus harbor genes with two distinct exon-intron GC content architectures th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ed63c2977c9923760199a500ce34b6
https://doi.org/10.1016/j.molcel.2022.02.001
https://doi.org/10.1016/j.molcel.2022.02.001
Autor:
Itay Sason, Damian Wojtowicz, Mark D.M. Leiserson, Welles Robinson, Roded Sharan, Teresa M. Przytycka
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783030170820
RECOMB
RECOMB
The characterization of mutational processes in terms of their signatures of activity relies, to the most part, on the assumption that mutations in a given cancer genome are independent of one another. Recently, it was discovered that certain segment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a92211fd04431c6e89749176c5784b
https://doi.org/10.1007/978-3-030-17083-7_15
https://doi.org/10.1007/978-3-030-17083-7_15
Publikováno v:
Machine Learning: Science and Technology. 2:015013
Non-negative matrix factorization (NMF) is a popular method for finding a low rank approximation of a matrix, thereby revealing the latent components behind it. In genomics, NMF is widely used to interpret mutation data and derive the underlying muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d5c1debff1ee840d808f27e6ed30572
https://doi.org/10.1088/2632-2153/abc60a
https://doi.org/10.1088/2632-2153/abc60a