Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Itay, Raphael"'
Autor:
Sarah R. Vincze, Ambika P. Jaswal, Stephen C. Frederico, Michal Nisnboym, Bo Li, Zujian Xiong, ReidAnn E. Sever, Chaim T. Sneiderman, Mikayla Rodgers, Kathryn E. Day, Joseph D. Latoche, Lesley M. Foley, T. Kevin Hitchens, Robin Frederick, Ravi B. Patel, Costas G. Hadjipanayis, Itay Raphael, Jessie R. Nedrow, W. Barry Edwards, Gary Kohanbash
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor. Currently, there are few effective treatment options for GBM beyond surgery and chemo-radiation, and even with these interventions, median patient survival remains poor. Wh
Externí odkaz:
https://doaj.org/article/fc294d0e99e04fd0a3d770a3246088f3
Autor:
Stephen C. Frederico, Nikhil Sharma, Corbin Darling, Suchet Taori, Alexandra C. Dubinsky, Xiaoran Zhang, Itay Raphael, Gary Kohanbash
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Pediatric high-grade glioma (pHGG) including pediatric glioblastoma (pGBM) are highly aggressive pediatric central nervous system (CNS) malignancies. pGBM comprises approximately 3% of all pediatric CNS malignancies and has a 5-year survival rate of
Externí odkaz:
https://doaj.org/article/fd00227a99eb4498a433b2be7888f5ce
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104963- (2024)
Summary: Glioblastoma (GBM) is one of the most lethal central nervous systems (CNS) tumours in adults. As supplements to standard of care (SOC), various immunotherapies improve the therapeutic effect in other cancers. Among them, tumour vaccines can
Externí odkaz:
https://doaj.org/article/f9e1c717f2e74d06b92da6fd603d9773
Autor:
Dennis W. Simon, Itay Raphael, Kendall M. Johnson, C. Edward Dixon, Vincent Vagni, Keri Janesko-Feldman, Patrick M. Kochanek, H?lya Bayir, Robert S.B. Clark, Mandy J. McGeachy
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 340-351 (2022)
Interleukin-17 (IL-17) is a proinflammatory cytokine primarily secreted in the brain by inflammatory T lymphocytes and glial cells. IL-17+ T-helper (Th17) cells are increased in the ipsilateral hemisphere after experimental traumatic brain injury (TB
Externí odkaz:
https://doaj.org/article/9df196680da748bd88313faa71ecf773
Autor:
Ornella Pagliano, Robert M. Morrison, Joe-Marc Chauvin, Hridesh Banerjee, Diwakar Davar, Quanquan Ding, Tokiyoshi Tanegashima, Wentao Gao, Saranya R. Chakka, Richelle DeBlasio, Ava Lowin, Kevin Kara, Mignane Ka, Bochra Zidi, Rada Amin, Itay Raphael, Shuowen Zhang, Simon C. Watkins, Cindy Sander, John M. Kirkwood, Marcus Bosenberg, Ana C. Anderson, Vijay K. Kuchroo, Lawrence P. Kane, Alan J. Korman, Arvind Rajpal, Sean M. West, Minhua Han, Christine Bee, Xiaodi Deng, Xiao Min Schebye, Pavel Strop, Hassane M. Zarour
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer immunity, we evaluated the effects of Tim-3 blockade in human and mouse melanom
Externí odkaz:
https://doaj.org/article/00341078d5a94f57ba93043742d00efb
Autor:
Alexandra Foster, Shubhanchi Nigam, David S Tatum, Itay Raphael, Jide Xu, Rajeev Kumar, Elizabeth Plakseychuk, Joseph D Latoche, Sarah Vincze, Bo Li, Rajan Giri, Lauren H McCarl, Robert Edinger, Murat Ak, Vishal Peddagangireddy, Lesley M Foley, T Kevin Hitchens, Rivka R Colen, Ian F Pollack, Ashok Panigrahy, Darren Magda, Carolyn J Anderson, W Barry Edwards, Gary Kohanbash
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103571- (2021)
Background: Malignant gliomas are deadly tumours with few therapeutic options. Although immunotherapy may be a promising therapeutic strategy for treating gliomas, a significant barrier is the CD11b+ tumour-associated myeloid cells (TAMCs), a heterog
Externí odkaz:
https://doaj.org/article/262ba25f595340aea3143132472fdff3
Publikováno v:
Cells, Vol 11, Iss 15, p 2442 (2022)
Quorum sensing (QS) was historically described as a mechanism by which bacteria detect and optimize their population density via gene regulation based on dynamic environmental cues. Recently, it was proposed that QS or similar mechanisms may have bro
Externí odkaz:
https://doaj.org/article/655715e20aeb411db1814e647d84b30c
Autor:
Itay Raphael, Rajeev Kumar, Lauren H. McCarl, Karsen Shoger, Lin Wang, Poorva Sandlesh, Chaim T. Sneiderman, Jordan Allen, Shuyan Zhai, Marissa Lynn Campagna, Alexandra Foster, Tullia C. Bruno, Sameer Agnihotri, Baoli Hu, Brandyn A. Castro, Frank S. Lieberman, Alberto Broniscer, Aaron A. Diaz, Nduka M. Amankulor, Dhivyaa Rajasundaram, Ian F. Pollack, Gary Kohanbash
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Glioblastoma (GBM) remains an aggressive brain tumor with a high rate of mortality. Immune checkpoint (IC) molecules are expressed on tumor infiltrating lymphocytes (TILs) and promote T cell exhaustion upon binding to IC ligands expressed by the tumo
Externí odkaz:
https://doaj.org/article/aec74bbb1c6b4bd1b658f3f136f5b61d
Autor:
Michal Nisnboym Ziv, Sarah R. Vincze, Itay Raphael, Zujian Xiong, Chaim T. Sneiderman, Rebecca A. Raphael, Bo Li, Ambika P. Jaswal, ReidAnn Sever, Kathryn E. Day, Joseph D. LaToche, Lesley M. Foley, T. Kevin Hitchens, Sameer Agnihotri, Baoli Hu, Dhivyaa Rajasundaram, Carolyn J. Anderson, Deborah T. Blumenthal, Thomas M. Pearce, Shikhar Uttam, Jessie R. Nedrow, Ashok Panigrahy, Ian F. Pollack, Frank S. Lieberman, Jan Drappatz, Wilson B. Edwards, Gary Kohanbash
Publikováno v:
Monday, April 24.
Autor:
Sirajul Salekin, Mehrab Ghanat Bari, Itay Raphael, Thomas G. Forsthuber, Jianqiu (Michelle) Zhang
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Identifying disease correlated features early before large number of molecules are impacted by disease progression with significant abundance change is very advantageous to biologists for developing early disease diagnosis biomark
Externí odkaz:
https://doaj.org/article/580dafe3fd3247cf914b2fd52383e3c0