Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Itaru Kojima"'
Autor:
Hiroaki Masubuchi, Manabu Ueno, Toshitaka Maeno, Koichi Yamaguchi, Kenichiro Hara, Hiroaki Sunaga, Hiroki Matsui, Masahiro Nagasawa, Itaru Kojima, Yuko Iwata, Shigeo Wakabayashi, Masahiko Kurabayashi
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Defective phagocytosis in alveolar macrophages is associated with chronic obstructive pulmonary disease (COPD). Transient receptor potential cation channel subfamily V member 2 (TRPV2), a type of nonselective cation channel pertin
Externí odkaz:
https://doaj.org/article/bf1e9297d75c4e1a92a4cb981f04780b
Autor:
Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M Rasenick, Takeshi Inagaki, Hiroshi Shibata
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181293 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0176841.].
Externí odkaz:
https://doaj.org/article/6b37699258714f75877732830120b6d3
Autor:
Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M Rasenick, Takeshi Inagaki, Hiroshi Shibata
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176841 (2017)
We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a Gαs-mediated but cAMP-independent mechanism. Here, we show that stimulatio
Externí odkaz:
https://doaj.org/article/4b19d67bb8e84d9ab3519b13872e9a91
Publikováno v:
Endocrinology and Metabolism, Vol 29, Iss 1, Pp 12-19 (2014)
The sweet taste receptors present in the taste buds are heterodimers comprised of T1R2 and T1R3. This receptor is also expressed in pancreatic β-cells. When the expression of receptor subunits is determined in β-cells by quantitative reverse transc
Externí odkaz:
https://doaj.org/article/fb8c60407d944c80b5f9836df728b829
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
The hypothalamic feeding center plays an important role in energy homeostasis. In the feeding center, whole-body energy signals including hormones and nutrients are sensed, processed, and integrated. As a result, food intake and energy expenditure ar
Externí odkaz:
https://doaj.org/article/ee070cfeb16e457cb8758781ca938b23
Autor:
Itaru Kojima, Yuko Nakagawa
Publikováno v:
Diabetes & Metabolism Journal, Vol 35, Iss 5, Pp 451-457 (2011)
The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor i
Externí odkaz:
https://doaj.org/article/bbe4e4f54dbc4b24915809ee7c9e49e2
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144053 (2015)
Glucose is a primary stimulator of insulin secretion in pancreatic β-cells. High concentration of glucose has been thought to exert its action solely through its metabolism. In this regard, we have recently reported that glucose also activates a cel
Externí odkaz:
https://doaj.org/article/85dcd73e6253412bb0c37d910a416cca
Autor:
Yosuke Masubuchi, Yuko Nakagawa, Jinhui Ma, Tsutomu Sasaki, Tadahiro Kitamura, Yoritsuna Yamamoto, Hitoshi Kurose, Itaru Kojima, Hiroshi Shibata
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54500 (2013)
BACKGROUND: Sweet taste receptor is expressed not only in taste buds but also in nongustatory organs such as enteroendocrine cells and pancreatic beta-cells, and may play more extensive physiological roles in energy metabolism. Here we examined the e
Externí odkaz:
https://doaj.org/article/90b07ffc46c4457d8a5b1ca8a81a1a03
Autor:
Sumiyo Morita, Akemi Hara, Itaru Kojima, Takuro Horii, Mika Kimura, Tadahiro Kitamura, Takahiro Ochiya, Katsumi Nakanishi, Ryo Matoba, Kenichi Matsubara, Izuho Hatada
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4212 (2009)
Dicer1, an essential component of RNA interference and the microRNA pathway, has many important roles in the morphogenesis of developing tissues. Dicer1 null mice have been reported to die at E7.5; therefore it is impossible to study its function in
Externí odkaz:
https://doaj.org/article/7e5d277bb37648ab9f57a5117461a8b2
Autor:
Yuko Nakagawa, Masahiro Nagasawa, Satoko Yamada, Akemi Hara, Hideo Mogami, Viacheslav O Nikolaev, Martin J Lohse, Noriatsu Shigemura, Yuzo Ninomiya, Itaru Kojima
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5106 (2009)
BACKGROUND:Sweet taste receptor is expressed in the taste buds and enteroendocrine cells acting as a sugar sensor. We investigated the expression and function of the sweet taste receptor in MIN6 cells and mouse islets. METHODOLOGY/PRINCIPAL FINDINGS:
Externí odkaz:
https://doaj.org/article/0f66c5983d664586ae47caaccbb9fce2