Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Itamar Simon"'
Autor:
Feras E. Machour, Enas R. Abu-Zhayia, Joyce Kamar, Alma Sophia Barisaac, Itamar Simon, Nabieh Ayoub
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The splicing factor RNA-binding motif protein 10 (RBM10) is frequently mutated in lung adenocarcinoma (LUAD) (9-25%). Most RBM10 cancer mutations are loss-of-function, correlating with increased tumorigenesis and limiting the efficacy of cur
Externí odkaz:
https://doaj.org/article/ae22363c12ae431e94e071bb14e3e944
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Cancer somatic mutations are the product of multiple mutational and repair processes, some of which are tightly associated with DNA replication. Mutation rates (MR) are known to be higher in late replication timing (RT) regions, but differen
Externí odkaz:
https://doaj.org/article/2d1440cf326b4cbeadbd8450c2ac09ee
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Mutational signatures’ association with replication timing (RT) has been studied in cancer samples, but the RT distribution of somatic mutations in non-cancerous cells was only minimally explored. Here, we performed comprehensive analyses
Externí odkaz:
https://doaj.org/article/b3dbb4c7d31f424383288e9ebf457a0f
Publikováno v:
Biology, Vol 13, Iss 3, p 175 (2024)
Traditional gene set enrichment analysis falters when applied to large genomic domains, where neighboring genes often share functions. This spatial dependency creates misleading enrichments, mistaking mere physical proximity for genuine biological co
Externí odkaz:
https://doaj.org/article/e7c22cc9f0aa45efb1c038df0991540d
Autor:
Sumin Feng, Sai Ma, Kejiao Li, Shengxian Gao, Shaokai Ning, Jinfeng Shang, Ruiyuan Guo, Yingying Chen, Britny Blumenfeld, Itamar Simon, Qing Li, Rong Guo, Dongyi Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The 53BP1-RIF1 pathway is important for DNA repair. Here, the authors identified the histone chaperone ASF1, which functions as a suppressor of DNA end resection through changing high-order chromatin structure, as a partner of RIF1. This finding link
Externí odkaz:
https://doaj.org/article/ec99cd67a7d1453f90b3cfcfa5828105
Autor:
Avital Zerbib, Itamar Simon
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9611 (2023)
Origins of replication are genomic regions in which replication initiates in a bidirectional manner. Recently, a new methodology (origin-derived single-stranded DNA sequencing; ori-SSDS) was developed that allows the detection of replication initiati
Externí odkaz:
https://doaj.org/article/18aabcc7e2784156bf9c89d2560a403e
Autor:
Britny Blumenfeld, Hagit Masika, Marganit Farago, Yishai Yehuda, Lamia Halaseh, Oriya Vardi, Rachel Rapoport, Rena Levin-Klein, Howard Cedar, Yehudit Bergman, Itamar Simon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Most regions of the mammalian genome replicate both alleles in a synchronous manner, but some loci have been found to replicate asynchronously and the time of replication of each allele is different. Here the authors, by employing clonal mouse cells
Externí odkaz:
https://doaj.org/article/5a44785bc8d24207acd6f75995d67d94
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection
Externí odkaz:
https://doaj.org/article/77db64bdcf0b41d78b52521cad53f925
Autor:
Avraham Greenberg, Itamar Simon
Publikováno v:
Biology, Vol 11, Iss 5, p 718 (2022)
The duration of the cell cycle has been extensively studied and a wide degree of variability exists between cells, tissues and organisms. However, the duration of S phase has often been neglected, due to the false assumption that S phase duration is
Externí odkaz:
https://doaj.org/article/37565148181e4be0819a0869e86fc22c
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172769 (2017)
Avoiding biases in next generation sequencing (NGS) library preparation is crucial for obtaining reliable sequencing data. Recently, a new library preparation method has been introduced which has eliminated the need for the ligation step. This method
Externí odkaz:
https://doaj.org/article/774e82ddef6c456194b4d42b8750a8dd