Výsledky vyhledávání - "Itamar C. G. Jesus"

Neuronal cholinergic signaling constrains norepinephrine activity in the heart

Autor: Diogo A. Guimarães, Nayara S. S. Aquino, Cibele Rocha-Resende, Itamar C. G. Jesus, Mario Morais Silva, Sérgio A. Scalzo, Roberta Cristelli Fonseca, Marina T. Durand, Vanessa Pereira, Geisa C. S. V. Tezini, André Oliveira, Vania F. Prado, Ivanita Stefanon, Helio C. Salgado, Marco Antônio Máximo Prado, Raphael E. Szawka, Silvia Guatimosim

Publikováno v: American journal of physiology. Cell physiology. 322(4)

It is well known that cholinergic hypofunction contributes to cardiac pathology, yet, the mechanisms involved remain unclear. Our previous study has shown that genetically engineered model of cholinergic deficit, the vesicular acetylcholine transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7025519677956931ec31bbc4fd839831
https://pubmed.ncbi.nlm.nih.gov/35264016

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Moving Pieces in a Cellular Puzzle: A Cryptic Peptide from the Scorpion Toxin Ts14 Activates AKT and ERK Signaling and Decreases Cardiac Myocyte Contractility via Dephosphorylation of Phospholamban

Autor: Frank Kjeldsen, Diana Paola Gómez-Mendoza, Silvia Guatimosim, John C. Vederas, Robson A.S. Santos, Adriano Marçal Pimenta, Thiago Verano-Braga, Shaun M. K. McKinnie, Vladimir Gorshkov, Rafael Pereira Lemos, Itamar C. G. Jesus

Publikováno v: Gómez-Mendoza, D P, Lemos, R P, Jesus, I, Gorshkov, V, McKinnie, S M K, Vederas, J C, Kjeldsen, F, Guatimosim, S, Santos, R A, Pimenta, A M C & Verano-Braga, T 2020, ' Moving pieces in a cellular puzzle : A cryptic peptide from the scorpion toxin Ts14 activates AKT and ERK signaling and decreases cardiac myocyte contractility via dephosphorylation of phospholamban ', Journal of proteome research, vol. 19, no. 8, pp. 3467-3477 . https://doi.org/10.1021/acs.jproteome.0c00290

Cryptic peptides (cryptides) are biologically active peptides formed after proteolysis of native precursors present in animal venoms, for example. Proteolysis is an overlooked post-translational modification that increases venom complexity. The tripe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9bc139ea858445c3200b181e8740fe
https://doi.org/10.1021/acs.jproteome.0c00290

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Molecular basis of Period 1 regulation by adrenergic signaling in the heart

Autor: Kaoma S. C. Silva, Thássio Ricardo Ribeiro Mesquita, Silvia Guatimosim, Cleide Lúcia Araújo Silva, Helio Cesar Salgado, Maristela O. Poletini, Raphael E. Szawka, Henrique Jorge Novaes Morgan, Alexander Birbrair, Luiz Carlos Carvalho Navegantes, Mário Morais Silva, Nilton Nascimentos dos Santos Júnior, Itamar C. G. Jesus, Flávio A. Amaral, Flávia M. Araújo

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(10)

The cardiac circadian clock is responsible for the modulation of different myocardial processes, and its dysregulation has been linked to disease development. How this clock machinery is regulated in the heart remains an open question. Because noradr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541db42f1be7374c6b041707c832665a
https://pubmed.ncbi.nlm.nih.gov/34473369

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Increased cholinergic activity under conditions of low estrogen leads to adverse cardiac remodeling

Autor: Itamar C. G. Jesus, Helio Cesar Salgado, Kiany Miranda, Marcos B. Melo, Anderson K. Santos, Marco A. M. Prado, Vanessa P. Teixeira, Silvia Guatimosim, Sérgio Scalzo, Fernando Pedro de Souza-Neto, Kaoma S. C. Silva, Mário Morais Silva, Geisa C.S.V. Tezini, Cibele Rocha-Resende, Mauro de Oliveira, Raphael E. Szawka, Maristela O. Poletini

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Cholinesterase inhibitors are used in postmenopausal women for the treatment of neurodegenerative diseases. Despite their widespread use in the clinical practice, little is known about the impact of augmented cholinergic signaling on cardiac function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cd27b32e9ba0fe480bb848809ef7f3
https://pubmed.ncbi.nlm.nih.gov/33296286

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Dense optical flow software to quantify cellular contractility

Autor: Oscar N. Mesquita, Flavio Augusto de Melo Marques, Estela Cruvinel, Diogo Biagi, Maria José Campagnole-Santos, Marcelo Querino Lima Afonso, Christopher Kushmerick, Kiany Miranda, Néli José da Fonseca, Ubirajara Agero, Silvia Guatimosim, Vanessa P. Teixeira, Carolina A. T. F. Mendonça, Anderson K. Santos, Itamar C. G. Jesus, Ana Paula Alves, Sérgio Scalzo

Publikováno v: Cell Reports: Methods, Vol 1, Iss 4, Pp 100044-(2021)

Summary: Cell membrane deformation is an important feature that occurs during many physiological processes, and its study has been put to good use to investigate cardiomyocyte function. Several methods have been developed to extract information on ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5d07147e1eca303c3d30319c8b8312
https://doi.org/10.1016/j.crmeth.2021.100044

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Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver

Publikováno v: Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
Brain Behav Immun
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior The gastrointestinal (GI) tract harbor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd318fc4ccb7b1d5dced900f4aeee78

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Alamandine acts via MrgD to induce AMPK/NO activation against ANG II hypertrophy in cardiomyocytes

Autor: Robson A.S. Santos, Silvia Guatimosim, Cibele Rocha-Resende, Sérgio Scalzo, Itamar C. G. Jesus, Kariny Marques, Fabiana Alves, Michael Bader

Publikováno v: American journal of physiology. Cell physiology. 314(6)

The renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases. New members of this system have been characterized and shown to have biologically relevant actions. Alamandine and its receptor MrgD are recently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b8529be9e7df86ffea69e9dbe4f437
https://pubmed.ncbi.nlm.nih.gov/29443552

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Beneficial Effects of Angiotensin-(1–7) Against Deoxycorticosterone Acetate–Induced Diastolic Dysfunction Occur Independently of Changes in Blood Pressure

Autor: Luciana Mitraud, Nivia M Santiago, Silvia Guatimosim, Marcos B. Melo, Itamar C. G. Jesus, Eduardo Nocchi, Leonardo Greco, Márcia N.M. Alves, Pedro W.M. Almeida, Maria José Campagnole-Santos, Rodrigo Ribeiro Resende, Robson A.S. Santos, Ricardo F. Lima, Mariana Gavioli, Amanda B. Parreira

Publikováno v: Hypertension. 66:389-395

Mineralocorticoids have been implicated in the pathogenesis of diastolic heart failure. On the contrary, angiotensin (Ang)-(1–7) has emerged as a potential strategy for treatment of cardiac dysfunction induced by excessive mineralocorticoid recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdd551e16ab957509af4176fc349f5ec
https://doi.org/10.1161/hypertensionaha.114.04893

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Testosterone deficiency prevents left ventricular contractility dysfunction after myocardial infarction

Autor: Aurélia Araújo Fernandes, Dalton Valentim Vassallo, Silvia Guatimosim, Pedro W.M. Almeida, Itamar C. G. Jesus, Karoline de Sousa Ronconi, Ivanita Stefanon, R. F. Ribeiro Junior, Ludimila Forechi

Publikováno v: Molecular and cellular endocrinology. 460

Testosterone may affect myocardial contractility since its deficiency decreases the contraction and relaxation of the heart. Meanwhile, testosterone replacement therapy has raised concerns because it may worsen cardiac dysfunction and remodeling afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad439d960c8056e1bfe017abe9b5479
https://pubmed.ncbi.nlm.nih.gov/28606867

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