Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Italo R. R. Martins"'
Autor:
Cibério L. Macêdo, Luiz H. C. Vasconcelos, Ana C. de C. Correia, Italo R. R. Martins, Daysianne P. de Lira, Bárbara V. de O. Santos, Fabiana de A. Cavalcante, Bagnólia A. da Silva
Publikováno v:
Molecules, Vol 19, Iss 12, Pp 19678-19695 (2014)
In this study, we investigated the relaxant action of galetin 3,6-dimethyl ether (FGAL) on rat aorta. The flavonoid relaxed both PMA‑ and phenylephrine (Phe)-induced contractions (pD2 = 5.36 ± 0.11 and 4.17 ± 0.10, respectively), suggesting the i
Externí odkaz:
https://doaj.org/article/b0ce864f5fe147e39d7034df2b658412
Autor:
Patrícia Machado Rodrigues e Silva, Everton Tenório de Souza, Sheyla Welma Duarte Silva, Marco Aurélio Martins, Manoel Oliveira de Moraes Junior, Vinicius F. Carvalho, Millena de Melo Medeiros, Bagnólia Araújo da Silva, Lídia Moreira Lima, Italo R. R. Martins, Isabelle Karine da Costa Nunes, Tatiane Luciano Balliano, Gisele Barbosa
Publikováno v:
European journal of medicinal chemistry. 204
Phosphodiesterase 4 (PDE4) inhibitors have emerged as a new strategy to treat asthma and other lung inflammatory diseases. Searching for new PDE4 inhibitors, we previously reported the discover of LASSBio-448, a sulfonamide with potential to prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7eb0c5cb42885dddf815c313c4a581
https://pubmed.ncbi.nlm.nih.gov/32717478
https://pubmed.ncbi.nlm.nih.gov/32717478
Autor:
Ana Carolina de Carvalho Correia, C. L. Macêdo, Bárbara Viviana de Oliveira Santos, Italo R. R. Martins, Bagnólia Araújo da Silva, Daysianne Pereira de Lira, Fabiana de Andrade Cavalcante, Luiz Henrique César Vasconcelos
Publikováno v:
Molecules, Vol 19, Iss 12, Pp 19678-19695 (2014)
Molecules
Volume 19
Issue 12
Pages 19678-19695
Molecules
Volume 19
Issue 12
Pages 19678-19695
In this study, we investigated the relaxant action of galetin 3,6-dimethyl ether (FGAL) on rat aorta. The flavonoid relaxed both PMA‑ and phenylephrine (Phe)-induced contractions (pD2 = 5.36 ± 0.11 and 4.17 ± 0.10, respectively), suggesting the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6016649432736ce21c6f129cc03d125c
http://www.mdpi.com/1420-3049/19/12/19678
http://www.mdpi.com/1420-3049/19/12/19678
Autor:
Marcus V. Buri, Marcelo Sobral da Silva, Ana Carolina de Carvalho Correia, Tamyris F. Ferreira, Italo R. R. Martins, C. L. Macêdo, Viviane L. A. Nouailhetas, Josean Fechine Tavares, Bagnólia Araújo da Silva, Vicente Carlos de Oliveira Costa, Edgar J. Paredes-Gamero, Vera L.S. Rigoni, Fabio de S. Monteiro
Publikováno v:
Natural Product Research. 29:980-984
Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as 'pimenteira da terra', and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63745789ec9ce13b80026b90a2690e8
https://doi.org/10.1080/14786419.2014.964706
https://doi.org/10.1080/14786419.2014.964706
Autor:
Rosimeire Ferreira dos Santos, Bagnólia Araújo da Silva, Viviane L. A. Nouailhetas, Edgar J. Paredes-Gamero, Rafael de Almeida Travassos, Vera L.S. Rigoni, Marcelo Sobral da Silva, Jeannine Aboulafia, Josean Fechine Tavares, Alice T. Ferreira, Italo R. R. Martins
Publikováno v:
European Journal of Pharmacology. 678(1-3):39-47
In this study we investigated the mechanism underlying the spasmolytic action of ent -7α-acetoxytrachyloban-18-oic acid (trachylobane-360) and ent -7α-hydroxytrachyloban-18-oic acid (trachylobane-318), diterpenes obtained from Xylopia langsdorfiana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb97f7efc5552462bddd447aea781c30
Autor:
Joedna Cavalcante Pereira, Alexandre Sérgio Silva, Aline de Freitas Brito, Bagnólia Araújo da Silva, Iara Leão Luna de Souza, Italo R. R. Martins
Publikováno v:
Journal of Smooth Muscle Research
Studies that evaluate the mechanisms for increased airway responsiveness are very sparse, although there are reports of exercise-induced bronchospasm. Therefore, we have evaluated the tracheal reactivity and the rate of lipid peroxidation after diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8f764ec35b90936dfdac300c891140
https://pubmed.ncbi.nlm.nih.gov/26497013
https://pubmed.ncbi.nlm.nih.gov/26497013
Autor:
C. L. Macêdo, Bárbara Viviana de Oliveira Santos, Daysianne Pereira de Lira, Italo R. R. Martins, Ana Carolina de Carvalho Correia, Bagnólia Araújo da Silva, Luiz Henrique César Vasconcelos
Publikováno v:
Zeitschrift fur Naturforschung. C, Journal of biosciences. 69(11-12)
Galetin 3,6-dimethyl ether (FGAL), a flavonoid from the aerial parts of Piptadenia stipulacea (Benth.) Ducke, was found to exert a relaxant effect on carbachol (CCh)-pre-contracted guinea-pig trachea. Based on cumulative concentration-response curves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e145f2b26f9d640cbe7815946d3371cf
https://pubmed.ncbi.nlm.nih.gov/25854763
https://pubmed.ncbi.nlm.nih.gov/25854763
Autor:
Italo R R, Martins, Rosimeire F, Dos Santos, Ana C, de C Correia, Gislaine A, de Oliveira, Cibério L, Macêdo, Fabio, de S Monteiro, Paula F, Dos Santos, Fabiana, de A Cavalcante, Josean F, Tavares, Bagnólia A, da Silva
Publikováno v:
Journal of Smooth Muscle Research
Ent-7α-hydroxytrachyloban-18-oic acid, a trachylobane diterpene from Xylopia langsdorfiana, has previously been shown to relax the guinea-pig trachea in a concentration-dependent manner. In this study we aimed to elucidate the mechanisms underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd0c7750ba6b91b929a4c07a7617f07e
https://pubmed.ncbi.nlm.nih.gov/23832615
https://pubmed.ncbi.nlm.nih.gov/23832615
Autor:
Rafael de Almeida Travassos, Marcelo Sobral da Silva, Josean Fechine Tavares, Italo R. R. Martins, Bagnólia Araújo da Silva, Fabio de S. Monteiro, Rosimeire F. Santos, Daniele Idalino Janebro
Publikováno v:
Natural product research. 26(24)
We aimed to investigate the possible spasmolytic activity of ent-7α-acetoxytrachyloban-18-oic acid (1) and ent-7α-hydroxytrachyloban-18-oic acid (2) on smooth muscle models. In male rat aorta and rat uterus, both diterpenes were unable to trigger s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8950ff57c74562966c61c8bb2e6be9f6
https://pubmed.ncbi.nlm.nih.gov/22288518
https://pubmed.ncbi.nlm.nih.gov/22288518
Autor:
Fabiana de Andrade Cavalcante, Ângelo C. Pinto, Ticiano P. Barbosa, Bagnólia Araújo da Silva, Celso A. Camara, Fabio de S. Monteiro, Italo R. R. Martins, Maria D. Vargas
Publikováno v:
Zeitschrift fur Naturforschung. C, Journal of biosciences. 65(9-10)
The present study was designed to further evaluate a possible spasmolytic activity of synthetic lapachol derivatives, norlapachol, α-norlapachone, β-norlapachone and hydro-hydroxy- norlapachol (HH-norlapachol), on guinea-pig ileum. In guinea-pig il
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a425970c1624073ba8c847ad3a9a42
https://pubmed.ncbi.nlm.nih.gov/21138067
https://pubmed.ncbi.nlm.nih.gov/21138067