Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Iswar K Hariharan"'
Publikováno v:
eLife, Vol 10 (2021)
In both vertebrates and invertebrates, generating a functional appendage requires interactions between ectoderm-derived epithelia and mesoderm-derived cells. To investigate such interactions, we used single-cell transcriptomics to generate a temporal
Externí odkaz:
https://doaj.org/article/8d58db8764c44bccad270a043bfec2ff
Publikováno v:
eLife, Vol 9 (2020)
Like tissues of many organisms, Drosophila imaginal discs lose the ability to regenerate as they mature. This loss of regenerative capacity coincides with reduced damage-responsive expression of multiple genes needed for regeneration. We previously s
Externí odkaz:
https://doaj.org/article/c316e7eeb39d442d8edd0cda25b0953f
Publikováno v:
eLife, Vol 7 (2018)
Regeneration following tissue damage often necessitates a mechanism for cellular re-programming, so that surviving cells can give rise to all cell types originally found in the damaged tissue. This process, if unchecked, can also generate cell types
Externí odkaz:
https://doaj.org/article/39c7f03f67dd44f3a91c8c47fb229e03
Publikováno v:
eLife, Vol 5 (2016)
Many organisms lose the capacity to regenerate damaged tissues as they mature. Damaged Drosophila imaginal discs regenerate efficiently early in the third larval instar (L3) but progressively lose this ability. This correlates with reduced damage-res
Externí odkaz:
https://doaj.org/article/fa7e454494d64198b84f58e9c8c2c592
Autor:
Justin A Bosch, Taryn M Sumabat, Yassi Hafezi, Brett J Pellock, Kevin D Gandhi, Iswar K Hariharan
Publikováno v:
eLife, Vol 3 (2014)
The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity (PCP) and proximodistal patterning. A key downstream component of Ft signaling is the atypical myosin Dachs (D). Multiple regions of the intracellular domain of Ft have been
Externí odkaz:
https://doaj.org/article/d28a439e46e9417990ecdecf856c49fa
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001206 (2010)
Obesity has a strong genetic component, but few of the genes that predispose to obesity are known. Genetic screens in invertebrates have the potential to identify genes and pathways that regulate the levels of stored fat, many of which are likely to
Externí odkaz:
https://doaj.org/article/1a591442edc9463591fdfca0fd951d98
Autor:
Sa Kan Yoo, Heath G. Pascoe, Telmo Pereira, Shu Kondo, Antonio Jacinto, Xuewu Zhang, Iswar K. Hariharan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Plexins are semaphorin receptors and are well known for their roles in neuronal pathfinding. Here the authors describe a role for Plexin A in healing damaged epithelia in Drosophila and zebrafish. In Drosophila, Plexin A inhibits the GTPase Rap1 to a
Externí odkaz:
https://doaj.org/article/3a1bb84c3e344ad8980c9438804e4793
Autor:
Sophia Friesen, Iswar K. Hariharan
Publikováno v:
bioRxiv
An epithelium in a living organism seldom develops in isolation. Rather, most epithelia are tethered to other epithelial or non-epithelial tissues, necessitating growth coordination between layers. We investigated how two tethered epithelial layers o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968149b276b5a350340102eae8462128
https://doi.org/10.1101/2023.02.26.530099
https://doi.org/10.1101/2023.02.26.530099
Whether regeneration is primarily accomplished by re-activating gene regulatory networks used previously during development or by activating novel regeneration-specific transcriptional programs remains a longstanding question. Currently, most genes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86204ed981ed152dcbcbde304c76ac72
https://doi.org/10.1101/2021.07.08.451678
https://doi.org/10.1101/2021.07.08.451678
Autor:
Iswar K. Hariharan, Jamie L. Lahvic
Publikováno v:
Molecular biology of the cell, vol 30, iss 14
Molecular Biology of the Cell
Molecular Biology of the Cell
Cancer treatments have, in general, targeted the cancer cell itself. This approach has often been unsuccessful in the long term, especially for solid tumors. Even targeted therapies based on sequencing cancer genomes can be thwarted by genetic hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8a2e258f3866f6ce668c9bd8843bfe
https://doi.org/10.1091/mbc.e19-03-0177
https://doi.org/10.1091/mbc.e19-03-0177