The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus

Autor: Ariane König, James Staunton, Peter F. Leadlay, Philip A. S. Lowden, Torsten Schwecke, Istvin Molnár, Günter A. Böhm

Publikováno v: König, A, Schwecke, T, Molnár, I, Böhm, G A, Lowden, P A S, Staunton, J & Leadlay, P F 1997, ' The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin-Nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus ', European Journal of Biochemistry, vol. 247, no. 2, pp. 526-534 . https://doi.org/10.1111/j.1432-1033.1997.00526.x

An open reading frame (rapP) encoding the putative pipecolate-incorporating enzyme (PIE) has been identified in the gene cluster for the biosynthesis of rapamycin in Streptomyces hygroscopicus. Conserved amino acid sequence motifs for ATP binding, AT

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https://pubmed.ncbi.nlm.nih.gov/9266694