Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Istvan Török"'
1
Drosophila Spag Is the Homolog of RNA Polymerase II-associated Protein 3 (RPAP3) and Recruits the Heat Shock Proteins 70 and 90 (Hsp70 and Hsp90) during the Assembly of Cellular Machineries
Autor: Ioannis Iliopoulos, Nour El Houda Benbahouche, Tore Kempf, Istvan Török, Philippe Meyer, Robert Farkaš, Edouard Bertrand, István Kiss, Julien Henri, Bernard M. Mechler, Bérengère Pradet-Balade, Andrey V. Kajava, Joachim Marhold, Martina Schnölzer
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2014, 289 (9), pp.6236--47. ⟨10.1074/jbc.M113.499608⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (9), pp.6236--47. ⟨10.1074/jbc.M113.499608⟩
The R2TP is a recently identified Hsp90 co-chaperone, composed of four proteins as follows: Pih1D1, RPAP3, and the AAA(+)-ATPases RUVBL1 and RUVBL2. In mammals, the R2TP is involved in the biogenesis of cellular machineries such as RNA polymerases, s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e0637b89bada28a508ab1d8fe16075
https://doi.org/10.1074/jbc.m113.499608
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2
Specific Cooperation Between Imp-α2 and Imp-β/Ketel in Spindle Assembly DuringDrosophilaEarly Nuclear Divisions
Autor: Bernard M. Mechler, István Kiss, Tolga Eichhorn, Istvan Török, Mátyás Gorjánácz, Erika Viragh, Tamás Szlanka, Sowjanya Kallakuri
Publikováno v: G3: Genes|Genomes|Genetics
The multifunctional factors Imp-α and Imp-β are involved in nuclear protein import, mitotic spindle dynamics, and nuclear membrane formation. Furthermore, each of the three members of the Imp-α family exerts distinct tasks during development. In D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a855aa19a0f9937e63acfb5cfab8b15
https://doi.org/10.1534/g3.111.001073
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3
Differential expression of two scribble isoforms during Drosophila embryogenesis
Autor: Mingfa Li, Joachim Marhold, Bernard M. Mechler, Anastasios Gatos, Istvan Török
Publikováno v: Mechanisms of Development. 108:185-190
The tumour suppressor gene scribble (scrib) is required for epithelial polarity and growth control in Drosophila. Here, we report the identification and embryonic expression pattern of two Scrib protein isoforms resulting from alternative splicing du
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e7ec1ba0ff3a8b049b809ca1bd9a19
https://doi.org/10.1016/s0925-4773(01)00482-8
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4
Structural and Functional Characterization of theDrosophilaGlycogen Phosphorylase Gene
Autor: István Kiss, Imre Cserpán, Viktor Dombrádi, Bernard M. Mechler, Gabriella Tick, Istvan Török
Publikováno v: Biochemical and Biophysical Research Communications. 257:34-43
We identified a P element insertional mutant of the Drosophila glycogen phosphorylase ( DGPH ) gene. Glycogen phosphorylase protein concentration and enzyme activity are decreased while glycogen content is increased in flies homozygous for the mutant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e103cbffeea40852f98728c668c4d46
https://doi.org/10.1006/bbrc.1999.0396
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5
Down-Regulation of RpS21, a Putative Translation Initiation Factor Interacting with P40, Produces Viable Minute Imagos and Larval Lethality with Overgrown Hematopoietic Organs and Imaginal Discs
Autor: István Kiss, Gabriela Tick, Daniela Herrmann-Horle, Istvan Török, Gábor Speer, Bernard M. Mechler, Rolf Schmitt
Publikováno v: Molecular and Cellular Biology. 19:2308-2321
Down-regulation of the Drosophila ribosomal protein S21 gene (rpS21) causes a dominant weak Minute phenotype and recessively produces massive hyperplasia of the hematopoietic organs and moderate overgrowth of the imaginal discs during larval developm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff95b91487149093c47c12fec09619b3
https://doi.org/10.1128/mcb.19.3.2308
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6
The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis
Autor: Tibor Török, István Kiss, Bernard M. Mechler, Dennis Strand, Gabriella Tick, Rolf Schmitt, Istvan Török
Publikováno v: The Journal of Cell Biology
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin protein of Xenopus (50% identity), the related yeast SRP1 protein, and the mammalian hSRP1 and RCH1 proteins.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d26ab93b97eb78b877aa7d99fd2ddb6
http://europepmc.org/articles/PMC2291178
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7
Drosophila as a model system for molecular analysis of tumorigenesis
Autor: Istvan Török, Bernard M. Mechler, Andreas Kalmes, Dennis Strand, Martina E. Schmidt, Reinhard Merz
Publikováno v: Environmental Health Perspectives
In Drosophila, homozygous mutations in a series of genes can cause the appearance of tissue-specific tumors. These tumors occur either during embryonic or larval development. The majority of the identified genes give rise to larval tumors that affect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9df2082cc4b371b287c2ed026c35b8
http://europepmc.org/articles/PMC1568063
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8
Molecular Basis for the Regulation of Cell Fate by the Lethal (2) Giant Larvae Tumour Suppressor Gene of Drosophila Melanogaster
Autor: Anne Kuhn, Bernard M. Mechler, Reinhard Merz, Martina Schmidt, Ursula Protin, Istvan Török, Martin Opper
Publikováno v: Ciba Foundation Symposium 142-Genetic Analysis of Tumour Suppression
Tumour suppressor genes act as recessive determinants of cancer. Their function is required for normal cell growth and differentiation during development. When both alleles of these developmental genes are inactivated, cell growth becomes unrestricte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbef3c8cf03b49d4ffdad21f89b35838
https://doi.org/10.1002/9780470513750.ch11
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9
Patterns of importin-alpha expression during Drosophila spermatogenesis
Autor: Rolf Schmitt, Mátyás Gorjánácz, Bernard M. Mechler, István Kiss, Marianna Giarrè, Istvan Török
Publikováno v: Journal of structural biology. 140(1-3)
Importin-alpha proteins do not only mediate the nuclear import of karyophilic proteins but also regulate spindle assembly during mitosis and the assembly of ring canals during Drosophila oogenesis. Three importin-alpha genes are present in the genome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9234f4761f53fc52e1b748d60c8988
https://pubmed.ncbi.nlm.nih.gov/12490175
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10
The congested-like tracheae gene of Drosophila melanogaster encodes a member of the mitochondrial carrier family required for gas-filling of the tracheal system and expansion of the wings after eclosion
Autor: Bernard M. Mechler, Istvan Török, Arati Mishra, Pradip Sinha, Heide Schenkel, Kirsten Hartenstein
Publikováno v: Genetics. 147(4)
A recessive semi-lethal mutation resulting from the insertion of a P-lacW transposon at the cytological position 23A on the polytene chromosomes of Drosophila melanogaster was found to affect the unfolding and expansion of the wings resulting in a lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05aec3b47b22db5f8c3c9babceef84af
https://pubmed.ncbi.nlm.nih.gov/9409834
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