Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Istvan Horvath"'
Autor:
Ella Sanders, Rebecca Csondor, Darius Šulskis, Ieva Baronaitė, Vytautas Smirnovas, Luckshi Maheswaran, Jack Horrocks, Rory Munro, Christina Georgiadou, Istvan Horvath, Ludmilla A. Morozova-Roche, Philip T. F. Williamson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13200 (2023)
The calcium-binding protein S100A9 is recognized as an important component of the brain neuroinflammatory response to the onset and development of neurodegenerative disease. S100A9 is intrinsically amyloidogenic and in vivo co-aggregates with amyloid
Externí odkaz:
https://doaj.org/article/dbe57bb098c44c8eb6ffe807cde740dc
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12849 (2023)
The assembly of α-synuclein into cross-β structured amyloid fibers results in Lewy body deposits and neuronal degeneration in Parkinson’s disease patients. As the cell environment is highly crowded, interactions between the formed amyloid fibers
Externí odkaz:
https://doaj.org/article/cfab2cc36bd14ce498b3279925d47032
Publikováno v:
QRB Discovery, Vol 2 (2021)
Although the consequences of the crowded cell environments may affect protein folding, function and misfolding reactions, these processes are often studied in dilute solutions in vitro. We here used biophysical experiments to investigate the amyloid
Externí odkaz:
https://doaj.org/article/b40209cc7320407b83ec5b6d9ddc1f2f
Publikováno v:
Universe, Vol 8, Iss 4, p 221 (2022)
Several hundred gamma-ray burst (GRB) redshifts have been determined to date. One of the other important properties—besides the distance—of the GRBs is the duration of the burst. In this paper, we analyse these two important quantities of the phe
Externí odkaz:
https://doaj.org/article/d291c16fe27a4c92967f4a48d7fddd04
Autor:
Timothy R Sampson, Collin Challis, Neha Jain, Anastasiya Moiseyenko, Mark S Ladinsky, Gauri G Shastri, Taren Thron, Brittany D Needham, Istvan Horvath, Justine W Debelius, Stefan Janssen, Rob Knight, Pernilla Wittung-Stafshede, Viviana Gradinaru, Matthew Chapman, Sarkis K Mazmanian
Publikováno v:
eLife, Vol 9 (2020)
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. While genetic and environmental factors can influence amyloid forma
Externí odkaz:
https://doaj.org/article/a828d9d829724627bc449f3bc4f8d4bc
Autor:
Istvan Horvath, Igor A. Iashchishyn, Roman A. Moskalenko, Chao Wang, Sebastian K. T. S. Wärmländer, Cecilia Wallin, Astrid Gräslund, Gabor G. Kovacs, Ludmilla A. Morozova-Roche
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-16 (2018)
Abstract Background Chronic neuroinflammation is a hallmark of Parkinson’s disease (PD) pathophysiology, associated with increased levels of pro-inflammatory factors in PD brain tissues. The pro-inflammatory mediator and highly amyloidogenic protei
Externí odkaz:
https://doaj.org/article/3b9ba4579bfc41a19ce74af63ca4e99b
Autor:
Emma Lorentzon, Istvan Horvath, Ranjeet Kumar, Joana Isabel Rodrigues, Markus J. Tamás, Pernilla Wittung-Stafshede
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11455 (2021)
Exposure to heavy metals, including arsenic and cadmium, is associated with neurodegenerative disorders such as Parkinson’s disease. However, the mechanistic details of how these metals contribute to pathogenesis are not well understood. To search
Externí odkaz:
https://doaj.org/article/93304e0595a04fb29a3e1ab124338036
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 924 (2020)
Plaque deposits composed of amyloid-β (Aβ) fibrils are pathological hallmarks of Alzheimer’s disease (AD). Although copper ion dyshomeostasis is apparent in AD brains and copper ions are found co-deposited with Aβ peptides in patients’ plaques
Externí odkaz:
https://doaj.org/article/335b8cd9a24e4aa592546e1f04ebddb2
Publikováno v:
ACS Chemical Neuroscience. 14:603-608
Publikováno v:
Nanoscale Advances. 4:4272-4278
Palladium ions complexed with nonlinear bidentate ligands have been shown to form hollow, spherical shells with high symmetries. We show that such structures can be reproduced using model anisotropic mesoscale building blocks featuring excluded volum