Transglutaminase 2 associated with PI3K and PTEN in a membrane-bound signalosome platform blunts cell death

Autor: Károly Jambrovics, Pál Botó, Attila Pap, Zsolt Sarang, Zsuzsanna Kolostyák, Zsolt Czimmerer, Istvan Szatmari, László Fésüs, Iván P. Uray, Zoltán Balajthy

Publikováno v: Cell Death and Disease, Vol 14, Iss 3, Pp 1-10 (2023)

Abstract Atypically expressed transglutaminase 2 (TG2) has been identified as a poor prognostic factor in a variety of cancers. In this study, we evaluated the contribution of TG2 to the prolonged cell survival of differentiated acute promyelocytic l

Externí odkaz: https://doaj.org/article/2af418809b3c4062a29a52c240c93479

Improved transgene expression in doxycycline-inducible embryonic stem cells by repeated chemical selection or cell sorting

Autor: Renáta Bencsik, Pal Boto, Renáta Nóra Szabó, Bianka Monika Toth, Emilia Simo, Bálint László Bálint, Istvan Szatmari

Publikováno v: Stem Cell Research, Vol 17, Iss 2, Pp 228-234 (2016)

Transgene-mediated programming is a preeminent strategy to direct cellular identity. To facilitate cell fate switching, lineage regulating genes must be efficiently and uniformly induced. However, gene expression is often heterogeneous in transgenic

Externí odkaz: https://doaj.org/article/d0d243e1d2294199bb4eda1969895e7a

RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells

Autor: Adrienn Gyöngyösi, Istvan Szatmari, Attila Pap, Balazs Dezső, Zoltan Pos, Lajos Széles, Tamas Varga, Laszlo Nagy

Publikováno v: Journal of Lipid Research, Vol 54, Iss 9, Pp 2458-2474 (2013)

All-trans retinoic acid (ATRA) has a key role in dendritic cells (DCs) and affects T cell subtype specification and gut homing. However, the identity of the permissive cell types and the required steps of conversion of vitamin A to biologically activ

Externí odkaz: https://doaj.org/article/2ba73c1133a94ba1bf484ac29e0ce6b3

An 8-hydroxyquinoline–proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes

Autor: Jelena Poljarević, Istvan Szatmari, János P. Mészáros, Norbert Szoboszlai, Éva A. Enyedy, Gabriella Spengler, Oszkár Csuvik, Ferenc Fülöp

Publikováno v: Dalton Transactions

Herein the design and synthesis of a new 8-hydroxyquinoline derivative, (S)-5-chloro-7-((proline-1-yl)methyl)8-hydroxyquinoline (HQCl-Pro), with good water solubility and multidrug resistance reversal activity are reported. In this work the proton di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6e50c473ed3733cde0568c057c1f6e
https://doi.org/10.1039/d0dt01256d

8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules

Autor: Tamás Pivarcsik, János P. Mészáros, Gabriella Spengler, Orsolya Dömötör, Oszkár Csuvik, Éva A. Enyedy, Istvan Szatmari, Nóra V. May

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11281, p 11281 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 20
Europe PubMed Central

Solution chemical properties of two novel 8-hydroxyquinoline-D-proline and homo-proline hybrids were investigated along with their complex formation with [Rh(η5-C5Me5)(H2O)3]2+ and [Ru(η6-p-cymene)(H2O)3]2+ ions by pH-potentiometry, UV-visible spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4f8501e64d850e3a66ee895b9b844b
https://www.mdpi.com/1422-0067/22/20/11281