Zobrazeno 1 - 10
of 17
pro vyhledávání: '"István Ledneczki"'
Autor:
Zsolt, Némethy, Béla, Kiss, Natasha, Lethbridge, Paul, Chazot, Tünde, Hajnik, Attila, Tóth, László, Détári, Éva, Schmidt, András, Czurkó, Diána, Kostyalik, Vilmos, Oláh, István, Hernádi, Ottilia, Balázs, E Sylvester, Vizi, István, Ledneczki, Sándor, Mahó, Viktor, Román, Balázs, Lendvai, György, Lévay
Publikováno v:
European journal of pharmacology. 916
The histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d00db9c21eae4a299c02b5487aa1036b
https://pubmed.ncbi.nlm.nih.gov/34965389
https://pubmed.ncbi.nlm.nih.gov/34965389
Autor:
Zsolt Némethy, Béla Kiss, Natasha Lethbridge, Paul Chazot, Tünde Hajnik, Attila Tóth, László Détári, Éva Schmidt, András Czurkó, Diána Kostyalik, Vilmos Oláh, István Hernádi, Ottilia Balázs, E. Sylvester Vizi, István Ledneczki, Sándor Mahó, Viktor Román, Balázs Lendvai, György Lévay
Publikováno v:
European Journal of Pharmacology. 916:174621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1beae2435563c1ece7c1fadf0cc0b9b3
https://doi.org/10.1016/j.ejphar.2021.174621
https://doi.org/10.1016/j.ejphar.2021.174621
Autor:
Zsolt Némethy, Balázs Lendvai, Balázs Krámos, Katalin Dudás Molnár, Ottilia Balázs, Anita Horváth, Áron Szigetvári, György Lévay, János Kóti, János Éles, Istvan Vago, István Ledneczki, András Visegrády, Mónika Vastag, Marta Than, Pál Tapolcsányi, Diána Kostyalik, Sándor Mahó, Sándor Kolok, Patrik Holm, László Fodor, István Greiner, László Kiss
Publikováno v:
European Journal of Medicinal Chemistry. 222:113560
HTS campaign of the corporate compound collection resulted in a novel, oxalic acid diamide scaffold of α7 nACh receptor positive allosteric modulators. During the hit expansion, several derivatives, such as 4, 11, 17 demonstrated not only high in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25756ef61e702aa21bdd1b8a5b62e5bf
https://doi.org/10.1016/j.ejmech.2021.113560
https://doi.org/10.1016/j.ejmech.2021.113560
Autor:
Viktor Román, Pál Tapolcsányi, György Lévay, István Greiner, István Ledneczki, János Éles, Rita Kedves, Sándor Mahó, Eszter Gábor, Ottilia Balázs, Eva Schmidt, Zsolt Némethy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4525-4530
Emerging from an HTS campaign, novel steroid-based histamine H3 receptor antagonists were identified and characterized. Structural moieties of the hit compounds were combined to improve binding affinities which resulted in compound 4 as lead molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8bdc6b2dbb983ae0f39a39b3fd260e
https://doi.org/10.1016/j.bmcl.2017.08.060
https://doi.org/10.1016/j.bmcl.2017.08.060
Autor:
István, Ledneczki, Zsolt, Némethy, Pál, Tapolcsányi, János, Éles, István, Greiner, Eszter, Gábor, Balázs, Varga, Ottilia, Balázs, Viktor, Román, György, Lévay, Sándor, Mahó
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(20)
To further proceed with our previous work, novel steroid-based histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f06502bad9ee854fbc29e3e4e010a5f
https://pubmed.ncbi.nlm.nih.gov/31492518
https://pubmed.ncbi.nlm.nih.gov/31492518
Autor:
Balázs Lendvai, Anna E. Káncz, Pál Tapolcsányi, Zoltán Béni, János Kóti, Marta Than, Éva Bozó, János Éles, István Greiner, Judit Laszy, Zsolt Némethy, Sándor Mahó, András Visegrády, Márton Vass, Gyula Bugovits, György Lévay, István Ledneczki, Anikó Pocsai, Balázs Krámos, Ágota Szájli, Mónika Vastag, Patrik Holm, Sándor Kolok, Eszter Gábor, Ottilia Balázs, Anita Horváth, József Nagy
Publikováno v:
European Journal of Medicinal Chemistry. 214:113189
The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor positive modulator (α7 nAChR PAM) ligands around the reference molecule (A-867744). First, substantial efforts were carried out to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ad9ffda37f8a3d089c88187d8a3c0f
https://doi.org/10.1016/j.ejmech.2021.113189
https://doi.org/10.1016/j.ejmech.2021.113189
Autor:
Eszter Gábor, Ottilia Balázs, Viktor Román, Pál Tapolcsányi, Zsolt Némethy, Sándor Mahó, István Greiner, János Éles, István Ledneczki, Balázs Varga, György Lévay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126643
To further proceed with our previous work, novel steroid-based histamine H3 receptor antagonists were identified and characterized. Using an ‘amine-to-amide’ modification strategy at position 17, in vitro and in vivo potent monoamino steroid deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46d39b1f94d035dec83076c38d8b8bf5
https://doi.org/10.1016/j.bmcl.2019.126643
https://doi.org/10.1016/j.bmcl.2019.126643
Publikováno v:
Journal of Fluorine Chemistry. 129:1036-1040
(PhSO2)2CFI was prepared in quantitative yield by the iodination of fluorobis(phenylsulfonyl)methane and utilized in facile radical bis(phenylsulfonyl)monofluoromethylation of various terminal alkenes. The synthetic methodology was further extended f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030353a620208d5a24c00eeae10f82db
https://doi.org/10.1016/j.jfluchem.2008.04.013
https://doi.org/10.1016/j.jfluchem.2008.04.013
Publikováno v:
Catalysis Letters. 119:296-303
Benzene and substituted derivatives (toluene, ortho-xylene, 1,2,3-trimethylbenzene, 1,2,4-trimethylbenzene, anisole), when applied in large excess, react with 1,4 diols (pentan-1,4-diol, hexan-2,5-diol, and 2,5-dimethylhexan-2,5-diol) or an oxolane (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60a9b7bbf1b543e951f51ad7ba96e686
https://doi.org/10.1007/s10562-007-9234-2
https://doi.org/10.1007/s10562-007-9234-2
Publikováno v:
Journal of Molecular Structure. :349-354
Four N-substituted and two N,N-disubstituted acetamides of related structures were studied with NMR spectroscopic and/or computational methods (force field, semiempirical and Hartree-Fock ab initio codes). The rotamers and the conformers were mapped.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfd0a1b506601854cc09d92a7c0558a8
https://doi.org/10.1016/j.molstruc.2006.11.017
https://doi.org/10.1016/j.molstruc.2006.11.017