Zobrazeno 1 - 10
of 65
pro vyhledávání: '"István Kolossváry"'
Autor:
István Kolossváry
Publikováno v:
JACS Au, Vol 4, Iss 4, Pp 1303-1309 (2024)
Externí odkaz:
https://doaj.org/article/550b57d576244d52a6ec199209620e60
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R. Shrestha, Rafal Wiewiora, Zachary A. McDargh, Fen Pei, Rajat Pal, João V. Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M. Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A. Izaguirre
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
The formation of ternary degrader-protein complexes is a key step in the targeted degradation of proteins of interest. Here, the authors explore the structure and dynamics of such complexes applying high-performance computer simulations augmented wit
Externí odkaz:
https://doaj.org/article/c2e5bdee6705479cb8aa835a2985b507
Autor:
JONATHAN M. FRASER, ISTVÁN KOLOSSVÁRY
Publikováno v:
Ergodic Theory and Dynamical Systems. :1-23
We derive upper and lower bounds for the Assouad and lower dimensions of self-affine measures in $\mathbb{R}^d$ generated by diagonal matrices and satisfying suitable separation conditions. The upper and lower bounds always coincide for $d=2,3$ yield
Autor:
István Kolossváry
Funding: Leverhulme Trust. Grant Number: RPG-2019-034. In this paper, a sponge in ℝd is the attractor of an iterated function system consisting of finitely many strictly contracting affine maps whose linear part is a diagonal matrix. A suitable sep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdbd831b5999af1c2dad3dddefbfc71
https://hdl.handle.net/10023/27621
https://hdl.handle.net/10023/27621
Publikováno v:
Journal of Number Theory. 234:120-139
We define a new metric between natural numbers induced by the $\ell_\infty$ norm of their unique prime signatures. In this space, we look at the natural analog of the number line and study the arithmetic function $L_\infty(N)$, which tabulates the cu
Autor:
István Kolossváry, Woody Sherman
Conformational sampling of complex biomolecules is an emerging frontier in drug discovery. Advances in lab-based structural biology and related computational approaches like AlphaFold have made great strides in obtaining static protein structures for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0283ffcb9d93a7f64551544244b61b
https://doi.org/10.1101/2023.03.26.534298
https://doi.org/10.1101/2023.03.26.534298
Publikováno v:
International Mathematics Research Notices. 2023:4456-4500
This paper studies how long it takes the orbit of the chaos game to reach a certain density inside the attractor of a strictly contracting iterated function system of which we only assume that its lower dimension is positive. We show that the rate of
Autor:
Bryce K. Allen, Meghana M. Kulkarni, Brian Chamberlain, Timothy Dwight, Cheryl Koh, Ramya Samant, Finith Jernigan, Jamie Rice, Dazhi Tan, Stella Li, Kristen Marino, Huang Huang, Evan Chiswick, Bethany Tesar, Sam Sparks, Zhixiong Lin, T. Dwight McGee, István Kolossváry, Charles Lin, Sharon Shechter, Holly Soutter, Cecilia Bastos, Mohammed Taimi, Sujen Lai, Alicia Petrin, Tracy Kane, Steven Swann, Humphrey Gardner, Christopher Winter, Woody Sherman
The protein STING (stimulator of interferon genes) is a central regulator of the innate immune system and plays an important role in antitumor immunity by inducing the production of cytokines such as type I interferon (IFN). Activation of STING stems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::007367283e6d03ce62189d7f16465731
https://doi.org/10.1101/2022.05.23.493001
https://doi.org/10.1101/2022.05.23.493001
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab Shrestha, Rafal Wiewiora, Zachary McDargh, Fen Pei, Rajat Pal, Joao Vieira Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus Izaguirre
Targeted protein degradation (TPD) has emerged as a powerful approach for removing (rather than inhibiting) proteins implicated in diseases. A key step in TPD is the formation of an induced proximity complex where a degrader molecule recruits an E3 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e7b51e04cb88578da974b61782146b
https://doi.org/10.21203/rs.3.rs-1318882/v1
https://doi.org/10.21203/rs.3.rs-1318882/v1
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R. Shrestha, Rafal Wiewiora, Zachary A. McDargh, Fen Pei, Rajat Pal, João V. Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M. Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A. Izaguirre
Targeted protein degradation (TPD) has emerged as a powerful approach in drug discovery for removing (rather than inhibiting) proteins implicated in diseases. A key step in this approach is the formation of an induced proximity complex, where a degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab72e51a2dd74a1d61536d796a4ff20
https://doi.org/10.1101/2021.09.26.461830
https://doi.org/10.1101/2021.09.26.461830