Half sandwich-type osmium, ruthenium, iridium and rhodium complexes with bidentate glycosyl heterocyclic ligands induce cytostasis in platinum-resistant ovarian cancer cells and bacteriostasis in Gram-positive multiresistant bacteria

Autor: István Kacsir, Adrienn Sipos, Tímea Kiss, Evelin Major, Nikolett Bajusz, Emese Tóth, Péter Buglyó, László Somsák, Gábor Kardos, Péter Bai, Éva Bokor

Publikováno v: Frontiers in Chemistry, Vol 11 (2023)

The toxicity of and resistance to platinum complexes as cisplatin, oxaliplatin or carboplatin calls for the replacement of these therapeutic agents in clinical settings. We have previously identified a set of half sandwich-type osmium, ruthenium and

Externí odkaz: https://doaj.org/article/a097cc70cbab47e5ba06c9f405874d2d

Targeting Multiresistant Gram-Positive Bacteria by Ruthenium, Osmium, Iridium and Rhodium Half-Sandwich Type Complexes With Bidentate Monosaccharide Ligands

Autor: Bence Balázs, Zoltán Tóth, István Kacsir, Adrienn Sipos, Péter Buglyó, László Somsák, Éva Bokor, Gábor Kardos, Péter Bai

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

Bacterial resistance to antibiotics is an ever-growing problem in heathcare. We have previously identified a set of osmium(II), ruthenium(II), iridium(III) and rhodium(III) half-sandwich type complexes with bidentate monosaccharide ligands possessing

Externí odkaz: https://doaj.org/article/a2acd9585db44ca6a45330e393caa0c9

Ruthenium Half-Sandwich Type Complexes with Bidentate Monosaccharide Ligands Show Antineoplastic Activity in Ovarian Cancer Cell Models through Reactive Oxygen Species Production

Autor: István Kacsir, Adrienn Sipos, Gyula Ujlaki, Péter Buglyó, László Somsák, Péter Bai, Éva Bokor

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 19, p 10454 (2021)

Ruthenium complexes are developed as substitutes for platinum complexes to be used in the chemotherapy of hematological and gynecological malignancies, such as ovarian cancer. We synthesized and screened 14 ruthenium half-sandwich complexes with bide

Externí odkaz: https://doaj.org/article/e2f21a8390e0411398a19a51e8efd3bb

Effect of the replacement of tripodal 4N donors by two 2N chelators on the redox and cytotoxic activity of maltolato and deferipronato containing Co(III) complexes

Autor: Sándor Nagy, Emese Tóth, István Kacsir, Attila Makai, Attila Bényei, Péter Buglyó

Publikováno v: Journal of inorganic biochemistry. 220

Fourteen novel CoIII ternary complexes with the general formula [Co(4 N)(2O)]X2 or [Co(2 N)2(2O)]X2 where 4 N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa); 2 N = 1,10-phenantroline (phen), 2,2′-bipyridine (bipy), 1,2-diamino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42998e7c5ab7ce04ee8c6ac4b6af55e3
https://pubmed.ncbi.nlm.nih.gov/33962134

Speciation in aqueous solution and interaction with low and high molecular mass blood bioligands of [VIVO(oda)(H2O)2], a V compound with in vitro anticancer activity

Autor: István Kacsir, Valeria Ugone, Sándor Nagy, Péter Buglyó, Eugenio Garribba, Daniele Sanna

Publikováno v: Inorganica Chimica Acta (Testo stamp.) 472 (2018): 127–138. doi:10.1016/j.ica.2017.07.064
info:cnr-pdr/source/autori:Sanna D.; Ugone V.; Buglyo P.; Nagy S.; Kacsir I.; Garribba E./titolo:Speciation in aqueous solution and interaction with low and high molecular mass blood bioligands of [VIVO(oda)(H2O)2], a V compound with in vitro anticancer activity/doi:10.1016%2Fj.ica.2017.07.064/rivista:Inorganica Chimica Acta (Testo stamp.)/anno:2018/pagina_da:127/pagina_a:138/intervallo_pagine:127–138/volume:472

In this work the speciation in aqueous solution of the compound [V IV O(oda)(H 2 O) 2 ], where oda is oxydiacetate dianion (OOCCH 2 ) 2 O, which shows in vitro anticancer activity, was studied. Its interaction with the two serum bioligands with highe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9d91730f5485936a7dbaa7bf0bd709
https://www.sciencedirect.com/science/article/pii/S0020169317306242