Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states

Autor: René A. M. Dirks, Guido van Mierlo, Hindrik H. D. Kerstens, Andreia S. Bernardo, Julianna Kobolák, István Bock, Julien Maruotti, Roger A. Pedersen, András Dinnyés, Martijn A. Huynen, Alice Jouneau, Hendrik Marks

Publikováno v: Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-21 (2019)

Abstract Background Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted genes in tissues from ea

Externí odkaz: https://doaj.org/article/ccab5f203e284c20b12ae65e88095907

Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)

Autor: Eszter Varga, Csilla Nemes, István Bock, Zsuzsanna Táncos, Sára Berzsenyi, György Lévay, Viktor Román, Julianna Kobolák, András Dinnyés

Publikováno v: Stem Cell Research, Vol 21, Iss C, Pp 19-22 (2017)

Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterized patient with autism spectrum disorder (ASD). The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus delivery system. The p

Externí odkaz: https://doaj.org/article/e038f76d70a14bd0b646c9f7c2bd321a

Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient

Autor: Csilla Nemes, Eszter Varga, Zsuzsanna Táncos, István Bock, Barbara Francz, Julianna Kobolák, András Dinnyés

Publikováno v: Stem Cell Research, Vol 17, Iss 1, Pp 69-71 (2016)

Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterised, early onset Alzheimer's disease patient, carries a heterozygous, pathogenic single nucleotide variation (SNV) in Presenilin1 (PSEN1) gene (NM_000021.3(PSEN1):c

Externí odkaz: https://doaj.org/article/dffc237a6fab49b3824d1da024190ba5

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

Autor: Bálint Jezsó, Phetcharat Phanthong, Kinga Molnár, Poul Hyttel, Maria Lo Giudice, Marianne Hoogeveen-Westerveld, Lajos László, W. Pijnappel, Shuling Zhou, Eszter Varga, Kristine K. Freude, István Bock, Annamária Téglási, Hideyuki Nakanishi, Norbert Varga, Andras Dinnyes, Narisorn Kitiyanant, Julianna Kobolák

Publikováno v: Experimental Cell Research, 380(2), 216-233. Elsevier Inc.
Kobolák, J, Molnár, K, Varga, E, Bock, I, Jezsó, B, Téglási, A, Zhou, S, Lo Giudice, M, Hoogeveen-Westerveld, M, Pijnappel, WWM P, Phanthong, P, Varga, N, Kitiyanant, N, Freude, K, Nakanishi, H, László, L, Hyttel, P & Dinnyés, A 2019, ' Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells ', Experimental Cell Research, vol. 380, no. 2, pp. 216-233 . https://doi.org/10.1016/j.yexcr.2019.04.021
Experimental Cell Research

Mucopolysaccharidosis II (MPS II) is a lysosomal storage disorder (LSD), caused by iduronate 2-sulphatase (IDS) enzyme dysfunction. The neuropathology of the disease is not well understood, although the neural symptoms are currently incurable. MPS II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad86d5ffcd6eef226f04a61c07001f7
https://doi.org/10.1016/j.yexcr.2019.04.021

Dissecting lineage specific oxidative stress response dynamics using high content imaging of the hiPSC HMOX1 fluorescent reporter line

Autor: István Bock, Julianna Kobolák, Marije Niemeijer, András Dinnyés, B. ter Braak, Anja Wilmes, Zsuzsanna Táncos, Paul Jennings, L. van den Berk, Kirsten E. Snijders, A. Bourguignon, Anita Fehér, B. van de Water, Catherine M. Verfaillie

Publikováno v: Toxicology Letters. 350:S23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::692026521369b522da7673aa06e27d9d
https://doi.org/10.1016/s0378-4274(21)00291-5