Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Issue 114"'
Publikováno v:
Journal of Visualized Experiments : JoVE
Methylation of cytosine bases (5-methylcytosine, 5mC) occurring in vertebrate genomes is usually associated with transcriptional silencing. 5-hydroxylmethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) are the recently discov
Publikováno v:
Journal of Visualized Experiments : JoVE
Improvements in mass spectrometry, sequencing and bioinformatics have generated large datasets of potentially interesting genes. Tagging these proteins can give insights into their function by determining their localization within the cell and enabli
Publikováno v:
Journal of Visualized Experiments : JoVE
Decline in hippocampal-dependent explicit memory (memory for facts and events) is one of the earliest clinical symptom of Alzheimer's disease (AD). It is well established that synapse loss and ensuing neurodegeneration are the best predictors for mem
Autor:
Michael S, Owens, Jeffrey C, Cornwell
Publikováno v:
Journal of Visualized Experiments : JoVE
The measurement of sediment-water exchange of gases and solutes in aquatic sediments provides data valuable for understanding the role of sediments in nutrient and gas cycles. After cores with intact sediment-water interfaces are collected, they are
Autor:
Rebecca A. Flaherty, Shaun W. Lee
Publikováno v:
Journal of Visualized Experiments : JoVE
Many bacterial pathogens secrete potent toxins to aid in the destruction of host tissue, to initiate signaling changes in host cells or to manipulate immune system responses during the course of infection. Though methods have been developed to succes
Autor:
Rebekka A. Larson, Brad E. Rosenheim, Erika E. Fridrik, Guy Grant, Jim Mulhollan, David W. Hastings, Ethan Goddard, Isabel C. Romero, Patrick Schwing, David J. Hollander, Gregg R. Brooks, Bryan J. O'Malley
Publikováno v:
Journal of Visualized Experiments : JoVE
Aquatic sediment core subsampling is commonly performed at cm or half-cm resolution. Depending on the sedimentation rate and depositional environment, this resolution provides records at the annual to decadal scale, at best. An extrusion method, usin
Publikováno v:
Journal of Visualized Experiments.
Cultured cardiomyocytes can be used to study cardiomyocyte biology using techniques that are complementary to in vivo systems. For example, the purity and accessibility of in vitro culture enables fine control over biochemical analyses, live imaging,
Publikováno v:
Journal of Visualized Experiments : JoVE
We present a high-temperature and high-pressure gas adsorption measurement device based on a high-frequency oscillating microbalance (5 MHz langatate crystal microbalance, LCM) and its use for gas adsorption measurements in zeolite H-ZSM-5. Prior to
Publikováno v:
Journal of Visualized Experiments : JoVE
There is a growing research interest in the development of portable systems which can deliver hydrogen on-demand to proton exchange membrane (PEM) hydrogen fuel cells. Researchers seeking to develop such systems require a method of measuring the gene
Publikováno v:
Journal of Visualized Experiments : JoVE
Isolated working heart models have been used to understand the effects of loading conditions, heart rate and medications on myocardial performance in ways that cannot be accomplished in vivo. For example, inotropic medications commonly also affect pr