Výsledky vyhledávání - "Issei S. Shimada"

Akademický článek

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Autor: Issei S. Shimada, Sun-Hee Hwang, Bandarigoda N. Somatilaka, Xin Wang, Patryk Skowron, Jiwoong Kim, Min Kim, John M. Shelton, Veena Rajaram, Zhenyu Xuan, Michael D. Taylor, Saikat Mukhopadhyay

Publikováno v: Cell Reports, Vol 22, Iss 5, Pp 1169-1184 (2018)

Summary: Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC progenitors during embryogenesis before Shh production by Purkinje neurons and their

Externí odkaz: https://doaj.org/article/a0e260af90be4ab48b629bd8b54149c8

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Biallelic null variants inPNPLA8cause microcephaly through the reduced abundance of basal radial glia

Autor: Yuji Nakamura, Issei S. Shimada, Reza Maroofian, Henry Houlden, Micol Falabella, Masanori Fujimoto, Emi Sato, Hiroshi Takase, Shiho Aoki, Akihiko Miyauchi, Eriko Koshimizu, Satoko Miyatake, Yuko Arioka, Mizuki Honda, Takayoshi Higashi, Fuyuki Miya, Yukimune Okubo, Isamu Ogawa, Annarita Scardamaglia, Mohammad Miryounesi, Sahar Alijanpour, Farzad Ahmadabadi, Peter Herkenrath, Hormos Salimi Dafsari, Clara Velmans, Mohammed Balwi, Antonio Vitobello, Anne-Sophie Denommé-Pichon, Médéric Jeanne, Antoine Civit, Maha S. Zaki, Hossein Darvish, Somayeh Bakhtiari, Michael Kruer, Christopher J Carroll, Ehsan Ghayoor Karimiani, Rozhgar A Khailany, Talib Adil Abdulqadir, Mehmet Ozaslan, Peter Bauer, Giovanni Zifarelli, Tahere Seifi, Mina Zamani, Chadi Al Alam, Robert D S Pitceathly, Kazuhiro Haginoya, Tamihide Matsunaga, Hitoshi Osaka, Naomichi Matsumoto, Norio Ozaki, Yasuyuki Ohkawa, Shinya Oki, Tatsuhiko Tsunoda, Yoshitaka Taketomi, Makoto Murakami, Yoichi Kato, Shinji Saitoh

PNPLA8, one of the calcium-independent phospholipase A2 enzymes, is involved in various physiological processes through the maintenance of membrane phospholipids. However, little is known about its role in brain development. Here, we report 12 indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3166c6dd5bfac2bccc9f569d1910b079
https://doi.org/10.1101/2023.04.26.23288947

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Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia

Autor: Vivek Reddy Palicharla, Sun-Hee Hwang, Bandarigoda N. Somatilaka, Emilie Legué, Issei S. Shimada, Nicole E. Familiari, Vanna M. Tran, Jeffrey B. Woodruff, Karel F. Liem, Saikat Mukhopadhyay

Publikováno v: Molecular Biology of the Cell. 34

Mechanisms of ciliary transport of ARL13B, a common ciliary protein, by TULP3 are described. An amphipathic helix preceding the ARL13B GTPase domain that couples with the TULP3 tubby domain for ciliary transport is identified. These findings implicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6373f5036e4f8759de244a936eada811
https://doi.org/10.1091/mbc.e22-10-0473

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Ciliary signaling in stem cells in health and disease: Hedgehog pathway and beyond

Autor: Issei S. Shimada, Yoichi Kato

Publikováno v: Seminars in celldevelopmental biology. 129

The primary cilium is a hair-like sensory compartment that protrudes from the cellular surface. The primary cilium is enriched in a variety of signaling molecules that regulate cellular activities. Stem cells have primary cilia. They reside in a spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170f4fddd00f4f7738685027e7b41e85
https://pubmed.ncbi.nlm.nih.gov/35466055

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Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities

Autor: Bandarigoda N. Somatilaka, Ashley G. Anderson, Genevieve Konopka, John M. Shelton, Saikat Mukhopadhyay, Veena Rajaram, Issei S. Shimada, Sun Hee Hwang

Publikováno v: Dev Biol

Inverse gradients of transcriptional repressors antagonize the transcriptional effector response to morphogens. However, the role of such inverse regulation might not manifest solely from lack of repressors. Sonic hedgehog (Shh) patterns the forebrai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899b3b48c339197a6719b0aac948046e
https://doi.org/10.1016/j.ydbio.2019.03.011

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Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Autor: Bandarigoda N. Somatilaka, Sun Hee Hwang, Michael D. Taylor, Xin Wang, Min Kim, Veena Rajaram, Jiwoong Kim, Patryk Skowron, Zhenyu Xuan, Issei S. Shimada, John M. Shelton, Saikat Mukhopadhyay

Publikováno v: Cell Reports, Vol 22, Iss 5, Pp 1169-1184 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2404f6186f117e6cab70425426176c
http://www.sciencedirect.com/science/article/pii/S2211124718300354

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G-protein-coupled receptor signaling and neural tube closure defects

Autor: Issei S. Shimada, Saikat Mukhopadhyay

Publikováno v: Birth Defects Research. 109:129-139

Disruption of the normal mechanisms that mediate neural tube closure can result in neural tube defects (NTDs) with devastating consequences in affected patients. With the advent of next-generation sequencing, we are increasingly detecting mutations i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdeacb8d84033b47adc9befac7cd228d
https://doi.org/10.1002/bdra.23567

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Basal Suppression of Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Autor: John M. Shelton, Zhenyu Xuan, Veena Rajaram, Min Kim, Issei S. Shimada, Sun-Hee Hwang, Patryk Skowron, Xin Wang, Jiwoong Kim, Bandarigoda N. Somatilaka, Saikat Mukhopadhyay, Michael D. Taylor

Publikováno v: SSRN Electronic Journal.

Sonic hedgehog (Shh) determines cerebellar granule progenitor proliferation and medulloblastoma pathogenesis. However, pathways regulating progenitors during embryogenesis before Shh production by Purkinje neurons and if such regulation affects tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af475c156a3dc57d44a184d212805ba5
https://doi.org/10.2139/ssrn.3155780

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Notch1–STAT3–ETB R signaling axis controls reactive astrocyte proliferation after brain injury

Autor: Jeffrey L. Spees, Issei S. Shimada, Casey Sherwin, Matthew D. LeComte

Publikováno v: Proceedings of the National Academy of Sciences. 112:8726-8731

Defining the signaling network that controls reactive astrogliosis may provide novel treatment targets for patients with diverse CNS injuries and pathologies. We report that the radial glial cell antigen RC2 identifies the majority of proliferating g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee49d7a3dc17f7fffebc97617b0661a7
https://doi.org/10.1073/pnas.1501029112

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Using Primary Neurosphere Cultures to Study Primary Cilia

Autor: Saikat Mukhopadhyay, Bandarigoda N. Somatilaka, Issei S. Shimada, Hemant B. Badgandi

Publikováno v: Journal of Visualized Experiments.

The primary cilium is fundamentally important for the proliferation of neural stem/progenitor cells and for neuronal differentiation during embryonic, postnatal, and adult life. In addition, most differentiated neurons possess primary cilia that hous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b03de9b6d50a0b6d0fbccefb69eede1
https://doi.org/10.3791/55315

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