Zobrazeno 1 - 10
of 398
pro vyhledávání: '"Issei, Imoto"'
Autor:
Yumiko Kasugai, Isao Oze, Yuriko N. Koyanagi, Yukari Taniyama, Hidemi Ito, Issei Imoto, Keitaro Matsuo
Publikováno v:
Journal of Epidemiology, Vol 34, Iss 10, Pp 498-502 (2024)
Externí odkaz:
https://doaj.org/article/6350806b414144c29208d8e542214d28
Publikováno v:
Human Genome Variation, Vol 11, Iss 1, Pp 1-3 (2024)
Abstract Loss-of-function germline variants of MLH1 cause Lynch syndrome. Here, we present the case of a 43-year-old male patient diagnosed with cecal and transverse colon adenocarcinomas. The characteristics of the case met the revised Bethesda guid
Externí odkaz:
https://doaj.org/article/9692b3475c954048ae15d43b3443f699
Autor:
Nobue Takaiso, Issei Imoto, Akiyo Yoshimura, Akira Ouchi, Koji Komori, Hiroji Iwata, Yasuhiro Shimizu
Publikováno v:
Human Genome Variation, Vol 11, Iss 1, Pp 1-4 (2024)
Abstract Deleterious germline variants in the BRCA1-associated ring domain (BARD1) gene moderately elevate breast cancer risk; however, their potential association with other neoplasms remains unclear. Here, we present the case of a 43-year-old femal
Externí odkaz:
https://doaj.org/article/0271519ac6a14e3db175fe4a94c023d8
Autor:
Takahiro Tsujikawa, Kazuchika Ohno, Kei-ichi Morita, Sumiyo Saburi, Junichi Mitsuda, Kanako Yoshimura, Alisa Kimura, Hiroki Morimoto, Hiroshi Ogi, Saya Shibata, Takumi Akashi, Morito Kurata, Issei Imoto, Yasushi Shimizu, Satoshi Kano, Akihito Watanabe, Tomoko Yamazaki, Yukinori Asada, Ryuichi Hayashi, Yuki Saito, Hiroyuki Ozawa, Kiyoaki Tsukahara, Nobuhiko Oridate, Daisuke Sano, Arata Horii, Yushi Ueki, Takashi Maruo, Nobuaki Mukoyama, Nobuhiro Hanai, Takahito Fukusumi, Hiroshi Iwai, Takuo Fujisawa, Takashi Fujii, Ken-ichi Nibu, Shigemichi Iwae, Tsutomu Ueda, Nobuyuki Chikuie, Ryuji Yasumatsu, Mioko Matsuo, Hirohito Umeno, Takeharu Ono, Muneyuki Masuda, Satoshi Toh, Kyoko Itoh, Shigeru Hirano, Takahiro Asakage
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIn view of improving biomarkers predicting the efficacy of immunotherapy for head and neck squamous cell carcinoma (R/M HNSCC), this multicenter retrospective study aimed to identify clinical, tumor microenvironmental, and genomic factors t
Externí odkaz:
https://doaj.org/article/b5c525023e134051b6b1b1fa136b47f3
Autor:
Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, Masanari Kodera, Yuichiro Shirai, Mitsuteru Akahoshi, Minoru Hasegawa, Takashi Matsushita, Kazuyoshi Saito, Sei-ichiro Motegi, Hajime Yoshifuji, Ayumi Yoshizaki, Tomohiro Kohmoto, Kae Takagi, Akira Oka, Miho Kanda, Yoshihito Tanaka, Yumi Ito, Kazuhisa Nakano, Hiroshi Kasamatsu, Akira Utsunomiya, Akiko Sekiguchi, Hiroaki Niiro, Masatoshi Jinnin, Katsunari Makino, Takamitsu Makino, Hironobu Ihn, Motohisa Yamamoto, Chisako Suzuki, Hiroki Takahashi, Emi Nishida, Akimichi Morita, Toshiyuki Yamamoto, Manabu Fujimoto, Yuya Kondo, Daisuke Goto, Takayuki Sumida, Naho Ayuzawa, Hidetoshi Yanagida, Tetsuya Horita, Tatsuya Atsumi, Hirahito Endo, Yoshihito Shima, Atsushi Kumanogoh, Jun Hirata, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Kohei Tomizuka, Soichiro Yoshino, Xiaoxi Liu, Shuji Ito, Keiko Hikino, Akari Suzuki, Yukihide Momozawa, Shiro Ikegawa, Yoshiya Tanaka, Osamu Ishikawa, Kazuhiko Takehara, Takeshi Torii, Shinichi Sato, Yukinori Okada, Tsuneyo Mimori, Fumihiko Matsuda, Koichi Matsuda, Tiffany Amariuta, Issei Imoto, Keitaro Matsuo, Masataka Kuwana, Yasushi Kawaguchi, Koichiro Ohmura, Chikashi Terao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region,
Externí odkaz:
https://doaj.org/article/2821292baef747248e9e487cef06ad07
Autor:
Xin‐Ming Shen, Tomohiko Nakata, Seiji Mizuno, Issei Imoto, Duygu Selcen, Kinji Ohno, Andrew G. Engel
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 5, Pp 732-743 (2023)
Abstract Objective To dissect the kinetic defects of acetylcholine receptor (AChR) γ subunit variant in an incomplete form of the Escobar syndrome without pterygium and compare it with those of a variant of corresponding residue in the AChR ε subun
Externí odkaz:
https://doaj.org/article/12fb62f583b14adf8b8977384aad2bd7
Autor:
Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N. Koyanagi, Masahiro Nakatochi, Yoichi Sutoh, Shiori Nakano, Isao Oze, Hidemi Ito, Taiki Yamaji, Norie Sawada, Masao Iwagami, Aya Kadota, Teruhide Koyama, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Keitaro Tanaka, Toshiro Takezaki, Issei Imoto, Midori Suzuki, Yukihide Momozawa, Kenji Takeuchi, Akira Narita, Atsushi Hozawa, Kengo Kinoshita, Atsushi Shimizu, Kozo Tanno, Keitaro Matsuo, Shoichiro Tsugane, Kenji Wakai, Makoto Sasaki, Masayuki Yamamoto, Motoki Iwasaki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation a
Externí odkaz:
https://doaj.org/article/d73e8c416d684075bbf696f66325bd86
Autor:
Ryoko Katagiri, Atsushi Goto, Shiori Nakano, Masahiro Nakatochi, Yuriko N. Koyanagi, Masao Iwagami, Akiko Hanyuda, Taiki Yamaji, Norie Sawada, Yohko Nakamura, Sho Nakamura, Kiyonori Kuriki, Sadao Suzuki, Issei Imoto, Yukihide Momozawa, Isao Oze, Hidemi Ito, Shoichiro Tsugane, Kenji Wakai, Keitaro Matsuo, Motoki Iwasaki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduced. 110 single nucleotide polymo
Externí odkaz:
https://doaj.org/article/226a35404fb24a6298522bfa5f3647ca
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background While molecular targeted drugs and other therapies are being developed for many tumors, pancreatic cancer is still considered to be the malignant tumor with the worst prognosis. We started this study to identify prognostic genes a
Externí odkaz:
https://doaj.org/article/3c032f0a7eea41aa860d0b05651d923c
Autor:
Issei Imoto, Masako Saito, Kenichi Suga, Tomohiro Kohmoto, Masanobu Otsu, Keisuke Horiuchi, Hironao Nakayama, Shigeki Higashiyama, Mayumi Sugimoto, Ayumi Sasaki, Yukako Homma, Miki Shono, Ryuji Nakagawa, Yasunobu Hayabuchi, Shoichiro Tange, Shoji Kagami, Kiyoshi Masuda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A disintegrin and metalloprotease 17 (ADAM17) is the major sheddase that processes more than 80 substrates, including tumour necrosis factor-α (TNFα). The homozygous genetic deficiency of ADAM17 causing a complete loss of ADAM17 expression
Externí odkaz:
https://doaj.org/article/f54d298d87a549a0b4eef6bb10764fdc