Non-targeted detection of food adulteration using an ensemble machine-learning model

Autor: Teresa Chung, Issan Yee San Tam, Nelly Yan Yan Lam, Yanni Yang, Boyang Liu, Billy He, Wengen Li, Jie Xu, Zhigang Yang, Lei Zhang, Jian Nong Cao, Lok-Ting Lau

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Abstract Recurrent incidents of economically motivated adulteration have long-lasting and devastating effects on public health, economy, and society. With the current food authentication methods being target-oriented, the lack of an effective methodo

Externí odkaz: https://doaj.org/article/e6ce65c4257f48c08ee1f1adca787938

Data from Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations

Autor: Maria Pik Wong, Lap-Ping Chung, Lik-Cheung Cheng, Alan Dart-Loon Sihoe, Daniel Tsin-Tien Chua, Vicky Pui-Chi Tin, Elaine Lai-Han Leung, Issan Yee-San Tam

Epidermal growth factor receptor (EGFR) mutations are common in lung adenocarcinomas, especially from nonsmoking women of Asian descent. We have previously shown EGFR mutations occur in >70% of lung adenocarcinoma from nonsmokers in our population wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df112e5abd3c413c350a3c0615138dd
https://doi.org/10.1158/1535-7163.c.6531815

Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

Autor: Mehul Sharma, Daniel Leung, Mana Momenilandi, Lauren C.W. Jones, Lucia Pacillo, Alyssa E. James, Jill R. Murrell, Selket Delafontaine, Jesmeen Maimaris, Maryam Vaseghi-Shanjani, Kate L. Del Bel, Henry Y. Lu, Gilbert T. Chua, Silvia Di Cesare, Oriol Fornes, Zhongyi Liu, Gigliola Di Matteo, Maggie P. Fu, Donato Amodio, Issan Yee San Tam, Gavin Shueng Wai Chan, Ashish A. Sharma, Joshua Dalmann, Robin van der Lee, Géraldine Blanchard-Rohner, Susan Lin, Quentin Philippot, Phillip A. Richmond, Jessica J. Lee, Allison Matthews, Michael Seear, Alexandra K. Turvey, Rachael L. Philips, Terri F. Brown-Whitehorn, Christopher J. Gray, Kosuke Izumi, James R. Treat, Kathleen H. Wood, Justin Lack, Asya Khleborodova, Julie E. Niemela, Xingtian Yang, Rui Liang, Lin Kui, Christina Sze Man Wong, Grace Wing Kit Poon, Alexander Hoischen, Caspar I. van der Made, Jing Yang, Koon Wing Chan, Jaime Sou Da Rosa Duque, Pamela Pui Wah Lee, Marco Hok Kung Ho, Brian Hon Yin Chung, Huong Thi Minh Le, Wanling Yang, Pejman Rohani, Ali Fouladvand, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Mohammad Miryounesi, Anne Puel, Mohammad Shahrooei, Andrea Finocchi, Paolo Rossi, Beatrice Rivalta, Cristina Cifaldi, Antonio Novelli, Chiara Passarelli, Stefania Arasi, Dominique Bullens, Kate Sauer, Tania Claeys, Catherine M. Biggs, Emma C. Morris, Sergio D. Rosenzweig, John J. O’Shea, Wyeth W. Wasserman, H. Melanie Bedford, Clara D.M. van Karnebeek, Paolo Palma, Siobhan O. Burns, Isabelle Meyts, Jean-Laurent Casanova, Jonathan J. Lyons, Nima Parvaneh, Anh Thi Van Nguyen, Caterina Cancrini, Jennifer Heimall, Hanan Ahmed, Margaret L. McKinnon, Yu Lung Lau, Vivien Béziat, Stuart E. Turvey

Publikováno v: Journal of Experimental Medicine, 220
Journal of Experimental Medicine, 220, 5

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a central role in the pathophysiology of allergic inflammation. We have identified 16 patients from 10 families spanning three continents with a profound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c287d6bde4f6efb981c86aed42d1504
https://hdl.handle.net/2066/290791

Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.

Autor: Yangyang Yu, Kwok Ho Yip, Issan Yee San Tam, Sze Wing Sam, Chun Wai Ng, Wei Zhang, Hang Yung Alaster Lau

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112989 (2014)

Mast cells are pivotal in the pathogenesis of allergy and inflammation. In addition to the classical IgE-dependent mechanism involving crosslinking of the high-affinity receptor for IgE (FcεRI), mast cells are also activated by Toll-like receptors (

Externí odkaz: https://doaj.org/article/20b2790c1e504b70a70d16c0e42ffaf2

Novel six-week protocol for generating functional human connective tissue-type (MCTC) mast cells from buffy coats

Autor: See-Ying Tam, H. Y. A. Lau, Issan Yee San Tam, Chun Wai Ng

Publikováno v: Inflammation Research. 66:25-37

The aim of this study was to develop a novel protocol for generating large populations of fully mature and functional human mast cells (HMC) from CD34+ hematopoietic stem cells which require less culturing time than previously reported methods. CD34+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6093fe473be1c7522bd95656b2667ba5
https://doi.org/10.1007/s00011-016-0989-z