Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Issam Zineh"'
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract Decades of research have demonstrated that a variety of cognitive biases can affect our judgment and ability to make rational decisions in personal and professional environments. The lengthy, risky, and costly nature of pharmaceutical resear
Externí odkaz:
https://doaj.org/article/44c3e3690e924c3e8a1e87cb07a11edd
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 11, Pp 1573-1576 (2023)
Externí odkaz:
https://doaj.org/article/3403c3b027e44653962206bc7f1dfc91
Autor:
Daphney Jean, Kunal Naik, Lauren Milligan, Stephen Hall, Shiew Mei Huang, Nina Isoherranen, Colleen Kuemmel, Paul Seo, Million A. Tegenge, Yaning Wang, Yuching Yang, Xinyuan Zhang, Liang Zhao, Ping Zhao, Jessica Benjamin, Kimberly Bergman, Joseph Grillo, Rajanikanth Madabushi, Fang Wu, Hao Zhu, Issam Zineh
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1271-1275 (2021)
Externí odkaz:
https://doaj.org/article/857bb5cce86240bba8f4309aa783564a
Autor:
Colleen Kuemmel, Yuching Yang, Xinyuan Zhang, Jeffry Florian, Hao Zhu, Million Tegenge, Shiew‐Mei Huang, Yaning Wang, Tina Morrison, Issam Zineh
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 1, Pp 21-28 (2020)
The use of computational models in drug development has grown during the past decade. These model‐informed drug development (MIDD) approaches can inform a variety of drug development and regulatory decisions. When used for regulatory decision makin
Externí odkaz:
https://doaj.org/article/d37d81d3f5484d88b5b2a2b282604b5b
Autor:
Liang Zhao, Zhichuan Li, Lanyan Fang, Myong-Jin Kim, Srikanth C. Nallani, Chandrahas G. Sahajwalla, Silvia N. Calderon, Rigoberto A. Roca, Kairui Feng, Issam Zineh, Robert Lionberger
Publikováno v:
EClinicalMedicine, Vol 41, Iss , Pp 101135- (2021)
Background: Over the past decade, U.S. FDA has approved 10 opioid analgesics in abuse-deterrent formulations (ADFs). ADFs are intended to reduce abuse of a prescription opioid through manipulation of the product to use one or more routes of abuse. Al
Externí odkaz:
https://doaj.org/article/96bba9afeafa417a89bd446a27aa3786
Autor:
Issam Zineh
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 336-339 (2019)
Externí odkaz:
https://doaj.org/article/90a39fc10ed14f64a55990955cea1d33
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 3, Pp 236-239 (2019)
Selecting a dose regimen that is both safe and effective for patients is one of the most critical elements of a successful drug development program. Titrating the dose regimen of a drug based on patient response may help to identify safe and effectiv
Externí odkaz:
https://doaj.org/article/95cef2f6e47f464084ba9d6af5f5931a
Autor:
Greg Welder, Issam Zineh, Michael A. Pacanowski, Jason S. Troutt, Guoqing Cao, Robert J. Konrad
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2714-2721 (2010)
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a key regulator of serum LDL-cholesterol (LDL-C) levels. PCSK9 is secreted by the liver into the plasma and binds the hepatic LDL receptor (LDLR), causing its subsequent degradation. We first d
Externí odkaz:
https://doaj.org/article/187324920d8f4dae8a837d81e9a01ab5
Autor:
Issam Zineh, Amber L Beitelshees, Gregory J Welder, Wei Hou, Nasser Chegini, Jun Wu, Sharon Cresci, Michael A Province, John A Spertus
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3117 (2008)
Endothelial inflammation with chemokine involvement contributes to acute coronary syndromes (ACS). We tested the hypothesis that variation in the chemokine gene CXCL5, which encodes epithelial neutrophil-activating peptide (ENA-78), is associated wit
Externí odkaz:
https://doaj.org/article/ebf2f580369d4429809866792a956f3e
Autor:
Sarah Ridge, Daphne Guinn, Elimika Pfuma Fletcher, Issam Zineh, Rajanikanth Madabushi, Anuradha Ramamoorthy
Publikováno v:
The Journal of Clinical Pharmacology. 63:695-703
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f761af18a1644e177a8864e04461f603
https://doi.org/10.1002/jcph.2208
https://doi.org/10.1002/jcph.2208