Anticancer effect of new cyclocoumarol derivatives

Autor: Racha Karaky, Joumana Al-Akhdar, Fatima Saab, Batoul Rostom, Wassim Shebaby, Mohamed Mroueh, Mona Diab-Assaf, Issam Kassab, Maité Sylla-Iyarreta Veitia

Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100220- (2024)

Coumarins have demonstrated a broad spectrum of pharmacological activities, including significant anticancer properties. Recently, a series of cyclocoumarol derivatives, a pyranocoumarin known for its anticoagulant and anti-inflammatory effects, have

Externí odkaz: https://doaj.org/article/0864f19a504947779aab6071cd0ff4c9

Novel and Selective TLR7 Antagonists among the Imidazo[1,2-a]pyrazines, Imidazo[1,5-a]quinoxalines, and Pyrazolo[1,5-a]quinoxalines Series

Autor: Carine Deleuze-Masquéfa, Soulaima Chamat, Issam Kassab, Nour Bou Karroum, Pierre-Antoine Bonnet, Cindy Patinote, Mona Diab-Assaf, Hasnaa Bouharoun-Tayoun, Jean-François Guichou, Pierre Cuq, Georges Moarbess

Publikováno v: Journal of Medicinal Chemistry. 62:7015-7031

The Toll-like receptors (TLRs) 7 and 8 play an important role in the immune system activation, and their agonists may therefore serve as promising candidate vaccine adjuvants. However, the chronic immune activation by excessive TLR stimulation is a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f287a1be945fb10181dddf0365af346
https://doi.org/10.1021/acs.jmedchem.9b00411

Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes

Autor: Georges Moarbess, Natalina Cirnat, Nour Bou Karroum, Issam Kassab, Carine Deleuze-Masquéfa, Pierre-Antoine Bonnet, Cindy Patinote

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, ⟨10.1016/j.ejmech.2020.112238⟩

The discovery of the TLRs family and more precisely its functions opened a variety of gates to modulate immunological host responses. TLRs 7/8 are located in the endosomal compartment and activate a specific signaling pathway in a MyD88-dependant man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de7f9bd79045fce8ce9d640b42bd466
https://hal.archives-ouvertes.fr/hal-02826850

Novel and Selective TLR7 Antagonists among the Imidazo[1,2

Autor: Nour, Bou Karroum, Georges, Moarbess, Jean-François, Guichou, Pierre-Antoine, Bonnet, Cindy, Patinote, Hasnaa, Bouharoun-Tayoun, Soulaima, Chamat, Pierre, Cuq, Mona, Diab-Assaf, Issam, Kassab, Carine, Deleuze-Masquefa

Publikováno v: Journal of medicinal chemistry. 62(15)

The Toll-like receptors (TLRs) 7 and 8 play an important role in the immune system activation, and their agonists may therefore serve as promising candidate vaccine adjuvants. However, the chronic immune activation by excessive TLR stimulation is a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e559df105f35a4f1969d967f25b02d09
https://pubmed.ncbi.nlm.nih.gov/31283223

Imidazo[1,2-a]pyrazine, Imidazo[1,5-a]quinoxaline and Pyrazolo[1,5-a]quinoxaline derivatives as IKK1 and IKK2 inhibitors

Autor: Kamel Hadj-Kaddour, Issam Kassab, Cindy Patinote, Nour Bou Karroum, Pierre-Antoine Bonnet, Georges Moarbess, Pierre Cuq, Carine Deleuze-Masquéfa, Mona Diab-Assaf

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2017, 138, pp.909-919. ⟨10.1016/j.ejmech.2017.07.021⟩

International audience; The transcription nuclear factor NF-κB plays a pivotal role in chronic and acute inflammatory diseases. Among the several and diverse strategies for inhibiting NF-κB, one of the most effective approach considered by the phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bc0f9ba5eb9f6ab228d32e37f6b83a
https://pubmed.ncbi.nlm.nih.gov/28750313