Parkinson's disease pathology is directly correlated to SIRT3 in human subjects and animal models: Implications for AAV.SIRT3-myc as a disease-modifying therapy.

Autor: Trinh D; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada., Israwi AR; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada., Brar H; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Villafuerte JEA; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Laylo R; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Patel H; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Jafri S; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Al Halabi L; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Sinnathurai S; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Reehal K; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Shi A; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Gnanamanogaran V; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Garabedian N; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Pham I; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada., Thrasher D; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Monnier PP; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada., Volpicelli-Daley LA; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Nash JE; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada. Electronic address: joanne.nash@utoronto.ca.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2023 Oct 15; Vol. 187, pp. 106287. Date of Electronic Publication: 2023 Sep 11.

Cellular models for discovering prion disease therapeutics: Progress and challenges.

Autor: Krance SH; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada., Luke R; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada., Shenouda M; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Israwi AR; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada., Colpitts SJ; Department of Immunology, University of Toronto, Toronto, ON, Canada., Darwish L; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada., Strauss M; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Watts JC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

Publikováno v: Journal of neurochemistry [J Neurochem] 2020 Apr; Vol. 153 (2), pp. 150-172. Date of Electronic Publication: 2020 Feb 03.