Výsledky vyhledávání - "Israil Pendrak"

First X-ray Cocrystal Structure of a Bacterial FabH Condensing Enzyme and a Small Molecule Inhibitor Achieved Using Rational Design and Homology Modeling

Autor: Martin Brandt, Robert A. Daines, Israil Pendrak, Glenn S. Van Aller, Martha S. Head, Kelvin Sham, Xiayang Qiu, Sanjay S. Khandekar, Carol Silverman, Alex K. Konstantinidis, Cheryl A. Janson, John T. Lonsdale

Publikováno v: Journal of Medicinal Chemistry. 46:5-8

The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was obtained by rational modification of a high throughput screening lead with the aid of a S. pneumoniae FabH homology mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b3298898c706796fb7eeb5a0076895
https://doi.org/10.1021/jm025571b

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Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist leucettamine A and related analogs

Autor: Jeffrey C. Boehm, William Dennis Kingsbury, Israil Pendrak, Dulcie B. Schmidt, Henry M. Sarau, James J. Foley, John G. Gleason

Publikováno v: Journal of Medicinal Chemistry. 36:3333-3340

The isolation and structure determination of the naturally occurring LTB 4 receptor antagonist Leucettamine A (1) was recently reported. 1 Herein we describe the synthesis of this natural product, the preparation of several analogues, and their effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfa3576d1d603e23a9df8637dbd2a66
https://doi.org/10.1021/jm00074a014

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Synthesis of structural analogs of leukotriene B4 and their receptor binding activity

Autor: Jack D. Leber, Israil Pendrak, James J. Foley, Henry M. Sarau, William Dennis Kingsbury, Dulcie B. Schmidt, Brenda Mallet, Robert A. Daines, Jeffery C. Boehm

Publikováno v: Journal of Medicinal Chemistry. 36:3308-3320

Structural analogs of leukotriene B 4 (LTB 4 ) were designed using a preferred conformation of LTB 4 (1). Appending an aromatic ring scaffold between LTB 4 carbons 7 and 11 led to quinoline analogs (3) and (1)5. A similar modification to the LTB 74 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d224db02fed14091034f201ab09f348
https://doi.org/10.1021/jm00074a012

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ChemInform Abstract: Trisubstituted Pyridine Leukotriene B4 Receptor Antagonists: Synthesis and Structure-Activity Relationships

Autor: Dulcie B. Schmidt, Israil Pendrak, Chambers Pamela Anne, Robert A. Daines, H. M. Sarau, Dalia R. Jakas, James J. Foley, William Dennis Kingsbury

Publikováno v: ChemInform. 25

A series of trisubstituted pyridines have been prepared that exhibit in vitro leukotriene B4 (LTB4, 1) receptor antagonist activity. Previous disubstituted pyridines from these labs showed high affinity for the LTB4 receptor but demonstrated agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b19404248306df39e97414c143760c9b
https://doi.org/10.1002/chin.199411153

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ChemInform Abstract: Synthesis of Cystamidin A (Pyrrole-3-Propanamide), a Reported Calpain Inhibitor

Autor: Israil Pendrak, Ron Bihovsky

Publikováno v: ChemInform. 27

The reported calpain inhibitor cystamidin A (1a, pyrrole-3-propanamide) and a regioisomer, pyrrole-2-propanamide (1b) have been synthesized from the corresponding pyrrolecarboxaldehydes. The previously assigned structure of cystamidin A is confirmed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93159eb58ba25c0587d4fe43c6435633
https://doi.org/10.1002/chin.199647109

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