Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Israel VL"'
Autor:
Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, Preeti Singh, Gil Bar-Sela, Hadassah Goldberg, Martin Götte, Andrew D. Sharrocks, Yaoyong Li, Ralph D. Sanderson, Neta Ilan, Israel Vlodavsky
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-13 (2024)
Abstract Unlike the intense research effort devoted to exploring the significance of heparanase in cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we explored the role of Hpa2 in breast cancer. Unexpectedly, we f
Externí odkaz:
https://doaj.org/article/09ad1fee324e44e58f2c01dcb813d1a6
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that Tre
Externí odkaz:
https://doaj.org/article/378775d4b0fd41108905367cda2de0de
Autor:
Lubov Turovsky, Ghazal Kheshaiboun, Gharam Yassen, Sara Nagosa, Ilanit Boyango, Aya Amitai-Lange, Swarnabh Bhattacharya, Neta Ilan, Israel Vlodavsky, Daniel Aberdam, Ruby Shalom-Feuerstein, Emily Avitan-Hersh
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-10 (2024)
Abstract miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation en
Externí odkaz:
https://doaj.org/article/81c6513c80504b699b3cd22ba2134fe7
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-14 (2023)
Abstract Heparanase 2 (Hpa2, HPSE2) is a close homolog of heparanase. Hpa2, however, lacks intrinsic heparan sulfate (HS)-degrading activity, the hallmark of heparanase enzymatic activity. Mutations of HPSE2 were identified in patients diagnosed with
Externí odkaz:
https://doaj.org/article/0af987c7bc6545cab4e60ac034148588
Publikováno v:
HemaSphere, Vol 7, p e25846d4 (2023)
Externí odkaz:
https://doaj.org/article/60148b467aa742649abe6de85f64194a
Publikováno v:
Cells, Vol 13, Iss 3, p 211 (2024)
Heparanase (Hpa1) is expressed by tumor cells and cells of the tumor microenvironment and functions to remodel the extracellular matrix (ECM) and regulate the bioavailability of ECM-bound factors that support tumor growth. Heparanase expression is up
Externí odkaz:
https://doaj.org/article/fffd5c17103540999b0c6b3a1ed24fd7
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Heparanase (HPA) is the predominant enzyme that cleaves heparan sulfate and plays a critical role in a variety of pathophysiological processes. HPA activity has been traditionally correlated with tumor metastasis due to participation in the
Externí odkaz:
https://doaj.org/article/c7c04ef977aa412abaae31eeaabfffdc
Autor:
Chae Syng Lee, Yajie Zhai, Rui Shang, Trevor Wong, Aurora J. Mattison, Haoning Howard Cen, James D. Johnson, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 23 (2022)
Background Lipoprotein lipase (LPL)‐derived fatty acid is a major source of energy for cardiac contraction. Synthesized in cardiomyocytes, LPL requires translocation to the vascular lumen for hydrolysis of lipoprotein triglyceride, an action mediat
Externí odkaz:
https://doaj.org/article/b682a2631d454208892d84b6c7a7e8a2
Autor:
Jingjing Liu, Ibrahim Knani, Miriam Gross-Cohen, Jiaxi Hu, Sumin Wang, Li Tang, Neta Ilan, Shiming Yang, Israel Vlodavsky
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 966-978 (2021)
Heparanase is highly implicated in tumor metastasis due to its capacity to cleave heparan sulfate and, consequently, remodel the extracellular matrix underlying epithelial and endothelial cells. In striking contrast, only little attention was given t
Externí odkaz:
https://doaj.org/article/c1829f3429b44e70ac8efc7fcc592dcb
Publikováno v:
Oncogenesis, Vol 12, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/7b2019c345d443ac81d0500853ef59d2