Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA.

Autor: Oscar Quintana-Bustamante, Sara Fañanas-Baquero, Israel Orman, Raul Torres, Philippe Duchateau, Laurent Poirot, Agnès Gouble, Juan A Bueren, Jose C Segovia

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223775 (2019)

Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme. Erythrocytes from PKD patients show an energetic imbalance and are susceptible t

Externí odkaz: https://doaj.org/article/bc19e9f86810475fa5dfb7db4bb8b2bc

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice

Autor: Agustín G. Zapata, Mercedes Dessy-Rodriguez, David Alfaro, Rebeca Sanchez, Israel Orman, Sara Fañanas-Baquero, Jordi Garcia Merino, Silvia Bermudez de Miguel, José C. Segovia, Rosa Yañez, Yolanda Fernandez Sainz, Juan A. Bueren, Oscar Quintana-Bustamante, Omaira Alberquilla, Federico Becerra Aparicio

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Haematologica

Hematopoietic Stem and Progenitor Cells are crucial in the maintenance of lifelong production of all blood cells. These Stem Cells are highly regulated to maintain homeostasis through a delicate balance between quiescence, self-renewal and differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4059c6b6d41ad384bd3761c1d868720

Estrogens Enhance Human Hematopoietic Stem Cell Engraftment in a Xenogenic Transplantation Model

Autor: Federico Becerra Aparicio, Sara Fañanas-Baquero, Jordi Garcia Merino, José C. Segovia, Silvia Bermudez de Miguel, Juan A. Bueren, Oscar Quintana Bustamante, Rosa Yañez, David Alfaro, Yolanda Fernandez, Israel Orman, Agustín G. Zapata

Publikováno v: Blood. 132:2042-2042

Hematopoietic Stem Cells (HSCs) is a rare cell population that sits atop a hierarchy of progenitors that become progressively restricted to several or a single blood lineage. HSCs are capable of self-renewal and multipotent differentiation to all blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2f77f71b02840a303ec90f106c50104
https://doi.org/10.1182/blood-2018-99-112104

In comparison with palm oil, dietary nut supplementation delays the progression of atherosclerotic lesions in female apoE-deficient mice

Autor: Natalia Guillén, Joaquín C. Surra, Cristina Barranquero, Jesús Osada, María A. Navarro, José C. Segovia, Israel Orman, María P. Torcal, Carmen Arnal

Publikováno v: The British journal of nutrition. 109(2)

Epidemiological studies have demonstrated the benefits of nut consumption on cardiovascular risk factors and CHD, attributed to their fatty acid profile, rich in unsaturated fatty acids, and also to other nutrients. The effect of nuts on atherosclero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13d9356a4ff5d79ac7ec6686fd5b88c
https://pubmed.ncbi.nlm.nih.gov/23302442

Squalene in a sex-dependent manner modulates atherosclerotic lesion which correlates with hepatic fat content in apoE-knockout male mice

Autor: Joaquín C. Surra, Carmen Arnal, Valentina Ruiz-Gutiérrez, José C. Segovia, María A. Navarro, Javier S. Perona, Alfonso J. Sarría, Sergio Acín, Israel Orman, Ricardo Carnicer, Jesús Osada, Natalia Guillén, Jose M. Arbones-Mainar

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

BACKGROUND: Squalene is an intermediate of cholesterol biosynthesis which can be obtained from the diet where it is abundant, for example, in olive oil. The effect of this isoprenoid on the development of atherosclerosis was investigated on apoE-knoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bd178c3518ba964652a731beaf0c05
http://hdl.handle.net/10261/55547