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Akademický článek
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
Autor: Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v: eLife, Vol 12 (2023)
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Externí odkaz: https://doaj.org/article/8d32f189375347eda9d14d8aef197263
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3
Abstract P4-08-09: Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2-deficiency
Autor: María L. Guantay, Cintia A. Garro, Sebastian Siri, María Pansa, Sonja Ghidelli-Disse, Natalia Paviolo, Ana Racca, Viviana Nicotra, Caius Radu, José L. Bocco, Rosana Felice, Israel Gloger, Marcel Muelbaier, Gerard Drewes, Kevin Madauss, Manuela García, Vanesa Gottifredi, Gastón Soria
Publikováno v: Cancer Research. 83:P4-08
BRCA2 is a well-established cancer driver in several human malignancies. While the remarkable success of PARP inhibitors proved the clinical potential of targeting BRCA deficiencies, the emergence of resistance mechanisms underscores the importance o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92c7c164e79a8dbc7c0ac155eb28d0ee
https://doi.org/10.1158/1538-7445.sabcs22-p4-08-09
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4
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
Autor: Sebastián Omar Siri, Julieta Martino, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v: eLife. 12
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02e4416eea641ab4ae8542b969bfab9b
https://doi.org/10.7554/elife.80254
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Inhibitors of ROCK kinases induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
Autor: Julieta Martino, Sebastián O. Siri, Natalia S. Paviolo, Cintia Garro, María F. Pansa, Sofía Carbajosa, Aaron C. Brown, José L. Bocco, Israel Gloger, Gerard Drewes, Kevin P. Madauss, Gastón Soria, Vanesa Gottifredi
BRCA2-deficient cells are highly sensitive to poly-ADP-ribose polymerase inhibitors (PARPi) due to their impaired homologous recombination repair. This increased cytotoxicity is triggered by DNA replication stress induced by PARP trapping on DNA. Thu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffecae89928f02ba12ad36a39cc787f0
https://doi.org/10.1101/2022.06.24.497514
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