Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Isra M. Darwech"'
Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells
Autor:
Ronald R. Hiebsch, Daniel S. Pereira, Robyn J Puro, Benjamin J. Capoccia, Gabriela Andrejeva, Isra M. Darwech, Michael J. Donio
Publikováno v:
J Immunol
The signal regulatory protein α (SIRPα)/CD47 axis has emerged as an important innate immune checkpoint that enables cancer cell escape from macrophage phagocytosis. SIRPα expression is limited to macrophages, dendritic cells, and neutrophils—cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fcc537b73a653ec81c927080c15780
https://pubmed.ncbi.nlm.nih.gov/33431660
https://pubmed.ncbi.nlm.nih.gov/33431660
Autor:
Mike J Donio, Daniel S. Pereira, Robyn J Puro, Benjamin J. Capoccia, W. Casey Wilson, Isra M. Darwech, Gabriela Andrejeva, Arun K Kashyap
Publikováno v:
Blood. 136:9-10
While T cell checkpoint inhibitors are mainstays of cancer immunotherapy, therapies that direct innate immune responses against cancer are lacking. CD47, a "don't eat me" signal, is an innate immune cell checkpoint which binds SIRPα on macrophages a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55374beb68c6604ac9983abbd0087f4f
https://doi.org/10.1182/blood-2020-140528
https://doi.org/10.1182/blood-2020-140528