Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Israël Casabon"'
Autor:
Adam M. Crowe, Israël Casabon, Kirstin L. Brown, Jie Liu, Jennifer Lian, Jason C. Rogalski, Timothy E. Hurst, Victor Snieckus, Leonard J. Foster, Lindsay D. Eltis
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT Most mycolic acid-containing actinobacteria and some proteobacteria use steroids as growth substrates, but the catabolism of the last two steroid rings has yet to be elucidated. In Mycobacterium tuberculosis, this pathway includes virulence
Externí odkaz:
https://doaj.org/article/8a695f8dfbf74f748bcfad84bcde434f
Autor:
John E. Gadbery, Jie Liu, Israël Casabon, Nicole S. Sampson, Xinxin Yang, Lindsay D. Eltis, Tianao Yuan, James W. Round, Keith T Story, Matthew F. Wipperman, Adam M. Crowe
Publikováno v:
Biochemistry
Steroid-degrading bacteria, including Mycobacterium tuberculosis (Mtb), utilize an architecturally distinct subfamily of acyl coenzyme A dehydrogenases (ACADs) for steroid catabolism. These ACADs are α2β2 heterotetramers that are usually encoded by
Autor:
Lindsay D. Eltis, Estefanía Merino, Álvaro Barrientos, José M. Luengo, Joaquín Rodríguez, Bodo Philipp, Adam M. Crowe, Johannes Holert, Elías R. Olivera, Israël Casabon
Publikováno v:
Environmental Microbiology. 17:47-63
Summary Pseudomonas putida DOC21, a soil-dwelling proteobacterium, catabolizes a variety of steroids and bile acids. Transposon mutagenesis and bioinformatics analyses identified four clusters of steroid degradation (std) genes encoding a single cata
Publikováno v:
Molecular Microbiology. 89:1201-1212
Summary Cholesterol catabolism is widespread in actinobacteria and is critical for Mycobacterium tuberculosis (Mtb) virulence. Catabolism of steroid nucleus rings C and D is poorly understood: it is initiated by the CoA thioesterification of 3aα-H-4
Publikováno v:
Journal of Bacteriology. 194:6720-6727
The bacterial uptake of steroids and their metabolites remains poorly understood. We investigated two transporters associated with cholate catabolism in Rhodococcus jostii RHA1. Reverse transcriptase quantitative-PCR indicated that an ATP-binding cas
Publikováno v:
Molecular Microbiology. 87:269-283
The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 is one of four predicted acyl-CoA synthetases poten
Autor:
Lindsay D. Eltis, Israël Casabon, Natalie C. J. Strynadka, Robert J. Gruninger, Jenna K. Capyk
Publikováno v:
Journal of Biological Chemistry. 286:40717-40724
Mycobacterium tuberculosis (Mtb), a significant global pathogen, contains a cholesterol catabolic pathway. Although the precise role of cholesterol catabolism in Mtb remains unclear, the Rieske monooxygenase in this pathway, 3-ketosteroid 9α-hydroxy
Publikováno v:
Biochemistry. 48:10765-10774
HPr is a central protein of the phosphoenolpyruvate:sugar phosphotransferase transport system (PTS). In streptococci, HPr can be phosphorylated at His(15) at the expense of PEP by enzyme I (EI) of the PTS, producing HPr(His approximately P). HPr can
Publikováno v:
Canadian Journal of Microbiology. 54:941-949
HPr is a protein of the phosphoenolpyruvate:sugar phosphotransferase transport system (PTS). In gram-positive bacteria, HPr can be phosphorylated on Ser-46 by the kinase/phosphorylase HprK/P and on His-15 by phospho-enzyme I (EI~P) of the PTS. In vit
Autor:
Adam M. Crowe, Peter J. Stogios, Elena Evdokimova, Israël Casabon, Lindsay D. Eltis, Alexei Savchenko
Catabolism of host cholesterol is critical to the virulence of Mycobacterium tuberculosis and is a potential target for novel therapeutics. KstR2, a TetR family repressor (TFR), regulates the expression of 15 genes encoding enzymes that catabolize th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6015a4a9f7e1469f85db5d05bc597bc7
https://europepmc.org/articles/PMC4294509/
https://europepmc.org/articles/PMC4294509/