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Malignant A-to-I RNA editing by ADAR1 drives T-cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing.

Autor: Rivera M; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Moores Cancer Center, La Jolla, CA 92037, USA., Zhang H; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Moores Cancer Center, La Jolla, CA 92037, USA., Pham J; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Isquith J; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Zhou QJ; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Moores Cancer Center, La Jolla, CA 92037, USA., Sasik R; Center for Computational Biology & Bioinformatics (CCBB), University of California, San Diego, La Jolla, 92093-0681., Mark A; Center for Computational Biology & Bioinformatics (CCBB), University of California, San Diego, La Jolla, 92093-0681., Ma W; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Holm F; Department of Women's and Children's Health, Division of Pediatric Oncology and Surgery, Karolinska Institutet, Sweden., Fisch KM; Center for Computational Biology & Bioinformatics (CCBB), University of California, San Diego, La Jolla, 92093-0681.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA., Kuo DJ; Moores Cancer Center, La Jolla, CA 92037, USA.; Division of Pediatric Hematology-Oncology, Rady Children's Hospital San Diego, University of California, San Diego, CA., Jamieson C; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Moores Cancer Center, La Jolla, CA 92037, USA., Jiang Q; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Moores Cancer Center, La Jolla, CA 92037, USA.

Publikováno v: Research square [Res Sq] 2023 Jun 16. Date of Electronic Publication: 2023 Jun 16.