Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii

Autor: Cristina Wasowski, Mariel Marder, Nadezdha E. Vergel, Javier Rincón, Mario F. Guerrero, Sara Emilia Giraldo, Pilar Puebla

Publikováno v: Biomédica: revista del Instituto Nacional de Salud, Vol 30, Iss 2, Pp 245-50 (2010)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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Introducción. El fraccionamiento fitoquímico de Valeriana pavonii, especie vegetal nativa utilizada tradicionalmente en Colombia con fines tranquilizantes, condujo al aislamiento e identificación de la isovaleramida, uno de los principios responsa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e564cc06bf3011b1ab4b57dab95f80c6
http://www.revistabiomedica.org/index.php/biomedica/article/view/187

ChemInform Abstract: Synthesis of N4-(2-Acetamido-2-deoxy-β-D-glucopyranosyl)-L-asparagine Analogues. n-Butyramide, 3-Chloropropionamide, 3-Aminopropionamide, and Isovaleramide Analogues

Autor: John M. Risley, Jerry J. Kaylor

Publikováno v: ChemInform. 32

The syntheses of four analogues of N 4 -(2-acetamido-2-deoxy-β- d -glucopyranosyl)- l -asparagine are described. Activated carboxylic acids were reacted with 2-acetamido-2-deoxy-β- d -glucopyranosylamine. n -Butyric anhydride gave N -(2-acetamido-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2d319902f73cf64feeda9a1f20b799f
https://doi.org/10.1002/chin.200131197

Could valerian have been the first anticonvulsant?

Autor: Mervyn J. Eadie

Publikováno v: Epilepsia. 45(11)

To assess the available evidence for the belief that valerian, highly recommended in the past for treating epilepsy, possessed real anticonvulsant effectiveness. Review of available literature. In 1592, Fabio Colonna, in his botanical classic Phytoba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c08b76c1b3c7cafad2743e6235e40f9
https://pubmed.ncbi.nlm.nih.gov/15509234

Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism

Autor: Vijay K. Chadha, Kevin G. Leidal, Bryce V. Plapp

Publikováno v: Journal of Medicinal Chemistry. 26:916-922

Sulfoxides and amides were tested as inhibitors of liver alcohol dehydrogenase and ethanol metabolism in rats. With both series of compounds, increasing the hydrophobicity resulted in better inhibition, and introduction of polar groups reduced inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12231aacee48f5c97e08adbc33f4bd44
https://doi.org/10.1021/jm00360a024

Preliminary Pharmacological Studies of Some Amides of Chloral and Alpha, Alpha, Beta-Trichlorobutyraldehyde†

Autor: Joseph P. Larocca, Woodrow R. Byrum

Publikováno v: Journal of the American Pharmaceutical Association (Scientific ed.). 41:100-102

The HD50 and LD50 for 19 amide derivatives of chloral and α,α,β-trichlorobutyraldehyde have been determined. Of these compounds, chloral butyramide, chloral isovaleramide, chloral 2-ethylbutyrarnide, and chloral 2-ethylcaproamide were found to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e746e058f19029a1715d0d997b3535
https://doi.org/10.1002/jps.3030410216