Výsledky vyhledávání - "Isoniazid/pharmacology"

What are the most efficacious treatment regimens for isoniazid-resistant tuberculosis? A systematic review and network meta-analysis

Autor: Katharina Kranzer, Marc Lipman, Ross J Harris, Nikolayevskyy, Ju Sang Kim, Obach D, Zhao H, Hollie-Ann Hatherell, Helen R. Stagg, Ibrahim Abubakar, Tsuchiya N

Publikováno v: Thorax
Stagg, H R, Harris, R J, Hatherell, H-A, Obach, D, Zhao, H, Tsuchiya, N, Kranzer, K, Nikolayevskyy, V, Kim, J, Lipman, M C & Abubakar, I 2016, ' What are the most efficacious treatment regimens for isoniazid-resistant tuberculosis? A systematic review and network meta-analysis ', Thorax, vol. 71, no. 10, pp. 940-9 . https://doi.org/10.1136/thoraxjnl-2015-208262

INTRODUCTION: Consensus on the best treatment regimens for patients with isoniazid-resistant TB is limited; global treatment guidelines differ. We undertook a systematic review and meta-analysis using mixed-treatment comparisons methodology to provid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29babb03878d45aacabf51afa22a229
https://doi.org/10.1136/thoraxjnl-2015-208262

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Quadruple-first line drug resistance in Mycobacterium tuberculosis in Vietnam: What can we learn from genes?

Autor: Thuong Thi Vu, Son Thai Nguyen, Thanh Hoa Thi Tran, Anh Duc Dang, Huy Quang Nguyen, Hung Van Nguyen, Ngoc-Lan Nguyen, Nhung Viet Nguyen, Anne-Laure Bañuls, Van Anh Thi Nguyen, Lucie Contamin

Publikováno v: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2017, 50, pp.55-61. ⟨10.1016/j.meegid.2017.02.012⟩

International audience; In Vietnam, a country with high tuberculosis (137/100.000 population) and multidrug-resistant (MDR)-TB burdens (7.8/100.000 population), little is known about the molecular signatures of drug resistance in general and more par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f671e1e17378b0c6057eb6eae9f1291
https://pubmed.ncbi.nlm.nih.gov/28214557

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Rapid Detection of Mycobacterium tuberculosis Strains Resistant to Isoniazid and/or Rifampicin: Standardization of Multiplex Polymerase Chain Reaction Analysis

Autor: Leen Rigouts, Jimena Collantes, Francesca Barletta Solari

Publikováno v: The American journal of tropical medicine and hygiene

Drug susceptibility testing using molecular techniques can enhance the identification of drug-resistant Mycobacterium tuberculosis. Two multiplex real-time polymerase chain reaction (qPCR) assays were developed to detect the most common resistance-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2182eefd0592ba0671108f9ae0b04c
https://hdl.handle.net/10067/1437240151162165141

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A field evaluation of the Hardy TB MODS Kit™ for the rapid phenotypic diagnosis of tuberculosis and multi-drug resistant tuberculosis

Autor: Mitzi Rodriguez, Dunia Faulx, Luz Caviedes, Chris Crudder, David Moore, Melissa Valdez, Jon S. Friedland, Edith Castillo, Jorge Coronel, Robert H. Gilman, Laura Martin, Louis Grandjean, Mutsumi Metzler

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107258 (2014)
PLoS ONE

BACKGROUND: Even though the WHO-endorsed, non-commercial MODS assay offers rapid, reliable TB liquid culture and phenotypic drug susceptibility testing (DST) at lower cost than any other diagnostic, uptake has been patchy. In part this reflects mispe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e53196d245516bde0529398e425cbf
http://europepmc.org/articles/PMC4167337?pdf=render

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Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis

Autor: Lukas, Fenner, Matthias, Egger, Thomas, Bodmer, Ekkehardt, Altpeter, Marcel, Zwahlen, Katia, Jaton, Gaby E, Pfyffer, Sonia, Borrell, Olivier, Dubuis, Thomas, Bruderer, Hans H, Siegrist, Hansjakob, Furrer, Alexandra, Calmy, Jan, Fehr, Jesica Mazza, Stalder, Béatrice, Ninet, Erik C, Böttger, Sebastien, Gagneux, S, Yerly

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, Vol. 56, No 6 (2012) pp. 3047-53
Antimicrobial agents and chemotherapy

Bacterial factors may contribute to the global emergence and spread of drug-resistant tuberculosis (TB). Only a few studies have reported on the interactions between different bacterial factors. We studied drug-resistant Mycobacterium tuberculosis is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b96631a6c023eaf408dbf9f48cf77ab
https://pubmed.ncbi.nlm.nih.gov/22470121

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Rapid detection of rifampicin- and isoniazid-resistant mycobacterium tuberculosis by high-resolution melting analysis

Autor: Danny C. T. Ong, Wing-Cheong Yam, Gilman Kit Hang Siu, Ann S. G. Lee

We have developed a high-resolution melting (HRM) assay to scan for mutations in the rpoB, inhA, ahpC, and katG genes and/or promoter regions for the detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis. For assay development,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bb7283002f6b96ab22ac3773deaf8a
http://hdl.handle.net/10722/125140

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Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity

Autor: Karamanakos, P. N., Trafalis, D. T., Geromichalos, G. D., Pappas, P., Harkitis, P., Konstandi, M., Marselos, M.

Increased activity of CYP2E1 has been associated with increased risk of chemically-mediated cancers, through enhanced activation of a variety of procarcinogens. In this context, inhibition of CYP2E1 is potentially of significance in xenobiotic toxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::41ce23ebfc62f15993501ed7d88002db
http://olympias.lib.uoi.gr/jspui/handle/123456789/20748

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Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA

Autor: Richard Y.T. Kao, Kwok-Yung Yuen, Wing-Hong Seto, Pak-Leung Ho, Tai Hing Lam, Wai Lok Woo, Wing-Cheong Yam, E. T. Y. Leung

Publikováno v: Antimicrobial agents and chemotherapy. 50(3)

Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ea092d11ae610963ff10b230b690b9
https://pubmed.ncbi.nlm.nih.gov/16495272

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Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release

Autor: Daniela N. Männel, R. Urbanczik, R. Urbaschek

Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc08bcc18f1ecf7be47bff2c15c98f6b
https://epub.uni-regensburg.de/21166/

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