Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt

Autor: Stephanie Schwalm, Martin Erhardt, Isolde Römer, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4, p 1396 (2020)

Ceramide kinase (CerK) is a lipid kinase that converts the proapoptotic ceramide to ceramide 1-phosphate, which has been proposed to have pro-malignant properties and regulate cell responses such as proliferation, migration, and inflammation. We used

Externí odkaz: https://doaj.org/article/b0873cd882c04775a9642f7bf752a7c2

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

Autor: Olivier Blanchard, Bisera Stepanovska, Manuel Starck, Martin Erhardt, Isolde Römer, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 5, p 1498 (2018)

Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate (S1P), which acts as a key regulator of inflammatory and fibrotic reactions, mainly via S1P receptor activation. Here, we show that in the human renal proximal tubular epithel

Externí odkaz: https://doaj.org/article/3006f2a5b62e46d497825225e500eff2

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

Autor: Bisera Stepanovska, Olivier Blanchard, Andrea Huwiler, Martin Erhardt, Uwe Zangemeister-Wittke, Manuel Thierry Starck, Isolde Römer, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter

Publikováno v: International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1498
International Journal of Molecular Sciences
Blanchard, Olivier; Stepanovska, Bisera; Starck, Manuel Thierry; Erhardt, Martin; Römer, Isolde; Meyer Zu Heringdorf, Dagmar; Pfeilschifter, Josef; Zangemeister-Wittke, Uwe; Huwiler, Andrea (2018). Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells. International journal of molecular sciences, 19(5) Molecular Diversity Preservation International MDPI 10.3390/ijms19051498
International Journal of Molecular Sciences, Vol 19, Iss 5, p 1498 (2018)

Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate (S1P), which acts as a key regulator of inflammatory and fibrotic reactions, mainly via S1P receptor activation. Here, we show that in the human renal proximal tubular epithel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8fcb385bef9d791777f9a93b37d1bc

Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells

Autor: Josef Pfeilschifter, Svetlana Bubnova, Stephanie Schwalm, Isolde Römer, Andrea Huwiler, Frauke Döll

Publikováno v: Biochemical and Biophysical Research Communications. 368:1020-1025

Sphingosine kinases (SK) catalyze the production of sphingosine-1-phosphate which in turn regulates cell responses such as proliferation and migration. Here, we show that exposure of the human endothelial cell line EA.hy 926 to hypoxia stimulates a i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83328c614b965df4a5739bf3826a6a44
https://doi.org/10.1016/j.bbrc.2008.01.132

The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death.

Autor: Pastukhov, Oleksandr¹, Schwalm, Stephanie², Zangemeister ‐ Wittke, Uwe¹, Fabbro, Doriano³, Bornancin, Frederic³, Japtok, Lukasz⁴, Kleuser, Burkhard⁴, Pfeilschifter, Josef², Huwiler, Andrea¹

Publikováno v: British Journal of Pharmacology. Dec2014, Vol. 171 Issue 24, p5829-5844. 16p. 9 Graphs.