Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Isolde M. Seiden"'
Autor:
Isolde M. Seiden, Christopher I. Bayly, Sophie Roy, Stacia Kargman, Sabina L.C. Keen, Yves Gareau, Kathleen J. Rowland, Nancy A. Thornberry, Donald W. Nicholson, Vicky M. Houtzager
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(11)
Caspase-3 is synthesized as a dormant proenzyme and is maintained in an inactive conformation by an Asp-Asp-Asp “safety-catch” regulatory tripeptide contained within a flexible loop near the large-subunit/small-subunit junction. Removal of this
Autor:
Donald W. Nicholson, Sophie Roy, Erin P. Peterson, Felicita Hornung, John P. Vaillancourt, Ben F. Koop, Paul Tawa, Jing Qi Huang, David P. MacPherson, Sabina L.C. Keen, Nancy A. Thornberry, Michael R. Hayden, Jamal Nasir, Dita M. Rasper, Isolde M. Seiden, Steve Xanthoudakis, Shawn C. Black, Michael J. Lenardo, Vicky M. Houtzager, Shinji Hadano, Duane Martindale
Publikováno v:
Scopus-Elsevier
Apoptotic cell suicide initiated by ligation of CD95 (Fas/APO-1) occurs through recruitment, oligomerization and autocatalytic activation of the cysteine protease, caspase-8 (MACH, FLICE, Mch5). An endogenous mammalian regulator of this process, name