A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP.

Autor: Sergei M Danilov, Michael S Wade, Sylva L Schwager, Ross G Douglas, Andrew B Nesterovitch, Isolda A Popova, Kyle D Hogarth, Nakul Bhardwaj, David E Schwartz, Edward D Sturrock, Joe G N Garcia

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88001 (2014)

BACKGROUND: Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of biologically-active peptides including the hemoregulatory tetrapeptide, Ac-SDKP, hydrolysed preferential

Externí odkaz: https://doaj.org/article/ffe120ace2814c07ab74584edaa8d8c5

An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.

Autor: Sergei M Danilov, Kerry Gordon, Andrew B Nesterovitch, Heinrich Lünsdorf, Zhenlong Chen, Maricela Castellon, Isolda A Popova, Sergey Kalinin, Emma Mendonca, Pavel A Petukhov, David E Schwartz, Richard D Minshall, Edward D Sturrock

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25952 (2011)

Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascula

Externí odkaz: https://doaj.org/article/e4685659f8fe479bbfb3139e066ac986

Urinary ACE Phenotyping as a Research and Diagnostic Tool: Identification of Sex-Dependent ACE Immunoreactivity

Autor: Alexander J. Kozuch, Pavel A. Petukhov, Miklos Fagyas, Isolda A. Popova, Matthew O. Lindeblad, Alexander P. Bobkov, Armais A. Kamalov, Attila Toth, Steven M. Dudek, Sergei M. Danilov

Publikováno v: Biomedicines, Vol 11, Iss 3, p 953 (2023)

Background: Angiotensin-converting enzyme (ACE) is highly expressed in renal proximal tubules, but ACE activity/levels in the urine are at least 100-fold lower than in the blood. Decreased proximal tubular ACE has been associated with renal tubular d

Externí odkaz: https://doaj.org/article/37ffa1ef834b48a5bd66f1abd7a3e615

Epitope mapping of novel monoclonal antibodies to human angiotensin I‐converting enzyme

Autor: Edward D. Sturrock, Sergei M. Danilov, Steven M. Dudek, Elena R. Chernykh, Alexander V. Lyubimov, Isolda A. Popova, Pavel A. Petukhov, Olga Leplina, Joe G.N. Garcia, Ilya Trakht, Lizelle Lubbe, Kalantarov Gavriil F

Publikováno v: Protein Sci

Angiotensin I-converting enzyme (ACE, CD143) plays a crucial role in blood pressure regulation, vascular remodeling, and immunity. A wide spectrum of mAbs to different epitopes on the N and C domains of human ACE have been generated and used to study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b2c024d27bbd2576abcbf90ec21843
https://europepmc.org/articles/PMC8284578/

A novel splice-site mutation in angiotensin I-converting enzyme (ACE) gene, c.3691+1G>A (IVS25+1G>A), causes a dramatic increase in circulating ace through deletion of the transmembrane anchor

Autor: Sergei M. Danilov, Alexandre Persu, A.H. Jan Danser, Leonid M. Irenge, Alexander Churbanov, Marta Cossu, Andrew B. Nesterovitch, Michel Lambert, Nathalie de Visscher, Jaap Deinum, Jérôme Ambroise, Isolda A. Popova, Jean Marc Minon, Jean-Luc Gala

Publikováno v: PLoS One, 8, 4
PLoS ONE, Vol 8, Iss 4, p e59537 (2013)
PLoS ONE
PLoS One, 8
PLoS One (print), 8(4). Public Library of Science
PLoS One, Vol. 8, no. 4, p. e59537 (2013)

Contains fulltext : 116540.pdf (Publisher’s version ) (Open Access) BACKGROUND: Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologically active peptides and plays a key role in blood pressure regulation and vascular remodeling.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5a2846e786f519e7315a4f420a9e94
https://hdl.handle.net/2066/116540