Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes

Autor: Ronald E. Ellis, Lewis Stevens, Wen Xu, Yuehui Zhao, Javier Munoz, Patrick T. McGrath, Lijiang Long, Irene Felipe

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
eLife
eLife, Vol 8 (2019)

Genes can encode multiple isoforms, broadening their functions and providing a molecular substrate to evolve phenotypic diversity. Evolution of isoform function is a potential route to adapt to new environments. Here we show that de novo, beneficial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f4beef47b090a7e81f7666c1e18ad0
https://doi.org/10.7554/elife.48119

Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes.

Autor: Xu W; School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States., Long L; School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States.; Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, United States., Zhao Y; School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States., Stevens L; Institute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Felipe I; Epithelial Carcinogenesis Group, Spanish National Cancer Research Center-CNIO, Madrid, Spain., Munoz J; Proteomics Unit-ProteoRed-ISCIII, Spanish National Cancer Research Center-CNIO, Madrid, Spain., Ellis RE; Department of Molecular Biology, Rowan University School of Osteopathic Medicine, Stratford, United States., McGrath PT; School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, United States.; School of Physics, Georgia Institute of Technology, Atlanta, United States.

Publikováno v: ELife [Elife] 2019 Sep 09; Vol. 8. Date of Electronic Publication: 2019 Sep 09.