Isobutyrylshikonin and isovalerylshikonin from the roots of Onosma visianii inhibit larval growth of the tobacco cutworm Spodoptera littoralis

Autor: Sut, Stefania, Pavela, Roman, Kolarčik, Vladislav, Lupidi, Giulio, Maggi, Filippo, Dall’Acqua, Stefano, Benelli, Giovanni

Publikováno v: In Industrial Crops & Products 15 December 2017 109:266-273

Isobutyrylshikonin inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in BV2 microglial cells by suppressing the PI3K/Akt-mediated nuclear transcription factor-κB pathway

Autor: Jayasooriya, Rajapaksha Gedara Prasad Tharanga, Lee, Kyoung-Tae, Kang, Chang-Hee, Dilshara, Matharage Gayani, Lee, Hak-Ju, Choi, Yung Hyun, Choi, Il-Whan, Kim, Gi-Young

Publikováno v: In Nutrition Research December 2014 34(12):1111-1119

[Study of isobutyrylshikonin inhibiting proliferation of colon carcinoma cells through PI3K/Akt/m-TOR pathway].

Autor: Zhong Y; Analysis Center of Guangdong Medical University, Zhanjiang 524023, China., Zheng XB; Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Cai KR; Analysis Center of Guangdong Medical University, Zhanjiang 524023, China., Huang QL; Analysis Center of Guangdong Medical University, Zhanjiang 524023, China., Ye H; Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang 524023, China., Huang Z; Department of Gastrointestinal Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China., Wang YC; Oncology Center, Affiliated Hospital of Guangdong medical University, Zhanjiang 524001, China., Zhu YZ; Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang 524023, China.

Publikováno v: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2018 Jun; Vol. 43 (11), pp. 2358-2364.

Isobutyrylshikonin has a potentially stronger cytotoxic effect in oral cancer cells than its analogue shikonin in vitro

Autor: Dae-Gun Park, Hae Ryoun Park, Hye Jung Kim, Young-Whan Choi, Da Jeong Kim, Bok Hee Woo

Publikováno v: Archives of Oral Biology. 116:104774

Objectives The aim of the present study was to identify the anticancer effects and the mechanisms of action of shikonin and its analogue isobutyrylshikonin in oral squamous carcinoma cells. Designs The cytotoxic effects of isobutyrylshikonin and shik

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bfb6f6a0a396b0d87004927df71f3b
https://doi.org/10.1016/j.archoralbio.2020.104774

Isobutyrylshikonin inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in BV2 microglial cells by suppressing the PI3K/Akt-mediated nuclear transcription factor-κB pathway

Autor: Il-Whan Choi, Yung Hyun Choi, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Gi-Young Kim, Kyoung-Tae Lee, Chang-Hee Kang, Matharage Gayani Dilshara, Hak-Ju Lee

Publikováno v: Nutrition research (New York, N.Y.). 34(12)

Microglia are important macrophages to defend against pathogens in the central nervous system (CNS); however, persistent or acute inflammation of microglia lead to CNS disorders via neuronal cell death. Therefore, we theorized that a good strategy fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d90795c46187b3c4fffee318cf82aa7
https://pubmed.ncbi.nlm.nih.gov/25454762