Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

Autor: Søren R. Paludan, Alon Schneider Hait, Sathya Darmalinggam, Mette Christiansen, Simon Muller Larsen, Jørgen Kjems, Darshana D. Kadekar, Kristina Eriksson, Serge Mostowy, Liviu Ionut Moldovan, Nanna-Sophie Brinck Andersen, Vanessa Sancho-Shimizu, Trine H. Mogensen, Lasse Sommer Kristensen, Isobel Parkes, David Olagnier, Marie Helleberg, Demi van der Horst, Michelle M. Thomsen, Mette Ratzer Freytag, Kristian Alsbjerg Skipper, Stine H. Rahbek, Jacob Giehm Mikkelsen, Christian Brandt, Chiranjeevi Bodda, Fanghui Ren

Publikováno v: Hait, A S, Olagnier, D, Sancho-Shimizu, V, Skipper, K A, Helleberg, M, Larsen, S M, Bodda, C, Moldovan, L I, Ren, F, Brinck Andersen, N-S, Thomsen, M M, Freytag, M R, Darmalinggam, S, Parkes, I, Kadekar, D D, Rahbek, S H, van der Horst, D, Kristensen, L S, Eriksson, K, Kjems, J, Mostowy, S, Christiansen, M, Mikkelsen, J G, Brandt, C T, Paludan, S R & Mogensen, T H 2020, ' Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans ', Science Immunology, vol. 5, no. 54, eabc2691 . https://doi.org/10.1126/sciimmunol.abc2691
Hait, A S, Olagnier, D, Sancho-Shimizu, V, Skipper, K A, Helleberg, M, Larsen, S M, Bodda, C, Moldovan, L I, Ren, F, Andersen, N S B, Thomsen, M M, Freytag, M R, Darmalinggam, S, Parkes, I, Kadekar, D D, Rahbek, S H, van der Horst, D, Kristensen, L S, Eriksson, K, Kjems, J, Mostowy, S, Christiansen, M, Mikkelsen, J G, Brandt, C T, Paludan, S R & Mogensen, T H 2021, ' Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans ', Science immunology, vol. 5, no. 54, eabc2691 . https://doi.org/10.1126/SCIIMMUNOL.ABC2691
Science Immunology

Recurrent herpesvirus infections can manifest in different forms of disease, including cold sores, genital herpes, and encephalitis. There is an incomplete understanding of the genetic and immunological factors conferring susceptibility to recurrent

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https://pure.au.dk/portal/da/publications/defects-in-lc3b2-and-atg4a-underlie-hsv2-meningitis-and-reveal-a-critical-role-for-autophagy-in-antiviral-defense-in-humans(660e28c6-e88f-4155-8813-69748e66d63d).html