Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Isobel Okoye"'
Autor:
Hazel Marriott, Marc Duchesne, Subhabrata Moitra, Isobel Okoye, Luke Gerla, Irvin Mayers, Jalal Moolji, Adil Adatia, Paige Lacy
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 13, p 3721 (2024)
Background: The secretion of alarmin cytokines by epithelial cells, including thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, initiates inflammatory cascades in asthma. However, alarmin cytokine expression in the upper airways in
Externí odkaz:
https://doaj.org/article/7744a0451f7842f7b98834f0c989f460
Autor:
Isobel Okoye, Shokrollah Elahi, Najmeh Bozorgmehr, John Walker, Julia Lu, Siavash Mashhouri, Petya Koleva
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer. However, only a portion of patients respond to such treatments. Therefore, it remains a prevailing clinical need to identify factors associated with acquired
Externí odkaz:
https://doaj.org/article/e69c91ea531e4688b3aa308ec5148695
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The exposure of the airway epithelium to external stimuli such as allergens, microbes, and air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal lymphopoietin (TSLP). IL-25, IL-33 and TSLP interact with their lig
Externí odkaz:
https://doaj.org/article/482c414ba6cf42c1819ec3c83b65a834
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010378 (2022)
CD8+ T cells play a crucial role against chronic viral infections, however, their effector functions are influenced by the expression of co-stimulatory/inhibitory receptors. For example, CD73 works with CD39 to convert highly inflammatory ATP to aden
Externí odkaz:
https://doaj.org/article/ece17fe25a6441d3893ea02358a367d4
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mature erythrocytes are the major metabolic regulators by transporting oxygen throughout the body. However, their precursors and progenitors defined as CD71+ Erythroid Cells (CECs) exhibit a wide range of immunomodulatory properties. Here, we uncover
Externí odkaz:
https://doaj.org/article/5399c74a56144cf3bd1c11fa4b0ec601
Autor:
Isobel Okoye, Lai Xu, Olaide Oyegbami, Shima Shahbaz, Desmond Pink, Priscilla Gao, Xuejun Sun, Shokrollah Elahi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
HIV latency is a challenge to the success of antiretroviral therapy (ART). Hence patients may benefit from interventions that efficiently reactivate the latent virus to be eliminated by ARTs. Here we show that plasma extracellular vesicles (pEVs) can
Externí odkaz:
https://doaj.org/article/a1f4bf36826041158724ce4d29d2bb9d
Autor:
Isobel Okoye, Lai Xu, Shokrollah Elahi, Najmeh Bozorgmehr, Olaide Oyegbami, Amelie Fontaine, Nanette Cox-Kennett, Loree M Larratt, Mark Hnatiuk, Andrei Fagarasanu, Joseph Brandwein, Anthea C Peters
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background T cell exhaustion compromises antitumor immunity, and a sustained elevation of co-inhibitory receptors is a hallmark of T cell exhaustion in solid tumors. Similarly, upregulation of co-inhibitory receptors has been reported in T cells in h
Externí odkaz:
https://doaj.org/article/11ff09849af740f7bcda5c2a3fbddfc0
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background We have previously reported that the upregulation of galectin-9 (Gal-9) on CD4+ and CD8+ T cells in HIV patients was associated with impaired T cell effector functions. Gal-9 is a ligand for T cell immunoglobulin and mucin domain-3, and it
Externí odkaz:
https://doaj.org/article/1a35a10a9e224ea1b92b87a66aaa560d
Autor:
Najmeh Bozorgmehr, Isobel Okoye, Siavash Mashhouri, Julia Lu, Petya Koleva, John Walker, Shokrollah Elahi
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e006595
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer. However, only a portion of patients respond to such treatments. Therefore, it remains a prevailing clinical need to identify factors associated with acquired r
Publikováno v:
Cancer Immunology, Immunotherapy. 69:1423-1436
On-treatment steroids for countering immune checkpoint inhibitor-induced inflammatory responses (irAEs) are a hallmark of cancer immunotherapy. However, the suppressive nature of steroids has raised questions regarding their ability to compromise the