Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Isobel Harada"'
Publikováno v:
Current drug metabolism. 22(7)
Membrane transporters play an important role in intestinal absorption, distribution and clearance of drugs. Additionally transporters along with enzymes regulate tissue exposures (e.g. liver, kidney and brain), which are important for safety and effi
Autor:
Gail Pearse, Isobel Harada, Tom Slocombe, Scott B. Berger, John Bertin, Allison M. Beal, Kathryn Fountain, Andrea C. Haynes, Alison Rowles, Thomas Gobbetti
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 4, Pp 1-4 (2020)
Cell Death and Disease, Vol 11, Iss 4, Pp 1-4 (2020)
Autor:
Colin A. Campbell, Martin Rüdiger, Kevin Lee, Jason Witherington, Isobel Harada, Rab K. Prinjha, Umesh Kumar, Simon Taylor, Neil D. Christensen, Rebecca C. Furze, Ian D. Holyer, Mary A. Morse, Sarah A. Brendle, Mao X. Chen, Jonathan Thomas Seal, Karla K. Balogh
Publikováno v:
Antiviral research. 154
The DNA papillomaviruses infect squamous epithelium and can cause persistent, benign and sometimes malignant hyperproliferative lesions. Effective antiviral drugs to treat human papillomavirus (HPV) infection are lacking and here we investigate the a
Autor:
Joe Coyle, Tomoko Smyth, Jayne Curry, Nicola G. Wallis, David M. Cross, Ruth Feltell, Isobel Harada, Brent Graham, Matthias Reule, Brian Williams, Hayley Angove, Lynsey Fazal, John Lyons, Neil T. Thompson
Publikováno v:
Cancer Sci
A ubiquitously expressed chaperone, heat shock protein 90 (HSP90) is of considerable interest as an oncology target because tumor cells and oncogenic proteins are acutely dependent on its activity. AT13387 (2,4‐dihydroxy‐5‐isopropyl‐phenyl)
Autor:
Mike A. Batey, Isobel Harada, Ruth Feltell, Gordon Saxty, Neil T. Thompson, George Ward, Edward J. Lewis, Yan Zhao, Timothy Perera, Julie Irving, David R. Newell, Christopher William Murray, Peter H. King, Lynsey Fazal, Ron Gilissen, Sharna J. Rich, Matthew S Squires, Patrik Angibaud
Publikováno v:
Cancer Research. 70:3626-3626
Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFR) signalling as being key to the molecular pathology of cancer. FGFR is a receptor tyrosine kinase which activates the ex
Autor:
John Lyons, Brent Graham, Isobel Harada, Tomoko Smyth, Jayne Curry, Matthias Reule, Neil Thompson, Lynsey Fazal
Publikováno v:
Molecular Cancer Therapeutics. 8:A217-A217
AT13387 is a novel small molecule inhibitor of HSP90. a member of a family of molecular chaperones. Previously we highlighted an association between the high affinity binding of AT13387 to the N-terminal ATPase domain of HSP90 and the duration of tar