Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Isobel H. Norville"'
Publikováno v:
Antibiotics, Vol 12, Iss 5, p 914 (2023)
The timing of the initiation of antibiotic treatment has been shown to impact the clinical outcome of many bacterial infections, including Q fever. Delayed, suboptimal or incorrect antibiotic treatment has been shown to result in poor prognosis, resu
Externí odkaz:
https://doaj.org/article/39ac790c551f40ad80b25cb03356ca8e
Autor:
M. Gill Hartley, Isobel H. Norville, Mark I. Richards, Kay B. Barnes, Kevin R. Bewley, Julia Vipond, Emma Rayner, Andreas Vente, Stuart J. Armstrong, Sarah V. Harding
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Finafloxacin is a novel fluoroquinolone with optimal antibacterial activity in low pH environments, therefore offering a therapeutic advantage over some traditional antibiotics, in treating bacterial infections associated with acidic foci. Coxiella b
Externí odkaz:
https://doaj.org/article/f4f2e56b2dbc445d90035502bac07138
Autor:
Olivia Goode, Ashley Smith, Ashraf Zarkan, Jehangir Cama, Brandon M. Invergo, Daaniyah Belgami, Santiago Caño-Muñiz, Jeremy Metz, Paul O’Neill, Aaron Jeffries, Isobel H. Norville, Jonathan David, David Summers, Stefano Pagliara
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Persister and viable but non-culturable (VBNC) cells are two clonal subpopulations that can survive multidrug exposure via a plethora of putative molecular mechanisms. Here, we combine microfluidics, time-lapse microscopy, and a plasmid-enco
Externí odkaz:
https://doaj.org/article/6d1f31061d5a4954937de418453ed324
Autor:
Claudia M. Hemsley, Paul A. O’Neill, Angela Essex-Lopresti, Isobel H. Norville, Tim P. Atkins, Richard W. Titball
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Coxiella burnetii is a zoonotic pathogen that resides in wild and domesticated animals across the globe and causes a febrile illness, Q fever, in humans. An improved understanding of the genetic diversity of C. burnetii is essenti
Externí odkaz:
https://doaj.org/article/7feff0f378f241909797f32a6bc2f5c7
Publikováno v:
Pathogens, Vol 10, Iss 5, p 604 (2021)
Coxiella burnetii is a zoonotic pathogen that resides in wild and domesticated animals across the globe and causes a febrile illness, Q fever, in humans. Several distinct genetic lineages or genomic groups have been shown to exist, with evidence for
Externí odkaz:
https://doaj.org/article/497529be7ba4413480322ca7d8c2507d
Autor:
Aleksandra Wlodek, Steve G. Kendrew, Nigel J. Coates, Adam Hold, Joanna Pogwizd, Steven Rudder, Lesley S. Sheehan, Sarah J. Higginbotham, Anna E. Stanley-Smith, Tony Warneck, Mohammad Nur-E-Alam, Markus Radzom, Christine J. Martin, Lois Overvoorde, Markiyan Samborskyy, Silke Alt, Daniel Heine, Guy T. Carter, Edmund I. Graziani, Frank E. Koehn, Leonard McDonald, Alexander Alanine, Rosa María Rodríguez Sarmiento, Suzan Keen Chao, Hasane Ratni, Lucinda Steward, Isobel H. Norville, Mitali Sarkar-Tyson, Steven J. Moss, Peter F. Leadlay, Barrie Wilkinson, Matthew A. Gregory
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.
Externí odkaz:
https://doaj.org/article/b36ef21246ab47bfb8cbd4e969caea7c
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Historically, disease progression in animal models of Q fever has been carried out using PCR to monitor the presence of Coxiella burnetii DNA in the host. However, the colonization and dissemination of other bacterial infections in animal models are
Externí odkaz:
https://doaj.org/article/63057ebfe1f44e60b7abf7ac7c0f1df0
Autor:
Jua Iwasaki, Donald D. Lorimer, Mirella Vivoli-Vega, Emily A. Kibble, Christopher S. Peacock, Jan Abendroth, Stephen J. Mayclin, David M. Dranow, Phillip G. Pierce, David Fox, Maria Lewis, Nicole M. Bzdyl, Sofie S. Kristensen, Timothy J. J. Inglis, Charlene M. Kahler, Charles S. Bond, Anja Hasenkopf, Florian Seufert, Jens Schmitz, Laura E. Marshall, Andrew E. Scott, Isobel H. Norville, Peter J. Myler, Ulrike Holzgrabe, Nicholas J. Harmer, Mitali Sarkar-Tyson
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:1625-1634
Background The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic m
Autor:
Andrew J. Wilkinson, Nicola Ooi, Jonathan Finlayson, Victoria E. Lee, David Lyth, Kathryn S. Maskew, Rebecca Newman, David Orr, Keith Ansell, Kristian Birchall, Peter Canning, Peter Coombs, Lucia Fusani, Ed McIver, João Pisco, Philip M. Ireland, Christopher Jenkins, Isobel H. Norville, Stephanie J. Southern, Richard Cowan, Gareth Hall, Catherine Kettleborough, Victoria J. Savage, Ian R. Cooper
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 90:129331
Autor:
Isobel H. Norville, Georgie Metters, Claudia M. Hemsley, Richard W. Titball, Andrea Kovacs-Simon
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1268-1278 (2020)
Virulence
article-version (VoR) Version of Record
Virulence
article-version (VoR) Version of Record
Larvae of the greater wax moth (Galleria mellonella) are susceptible to infection with C. burnetii, an obligate intracellular bacterial pathogen. We show that bacteria are found in hemocytes after infection, and occupy vacuoles which are morphologica