Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ismar, Klebic"'
Autor:
Diego Dibitetto, Martin Liptay, Francesca Vivalda, Hülya Dogan, Ewa Gogola, Martín González Fernández, Alexandra Duarte, Jonas A. Schmid, Morgane Decollogny, Paola Francica, Sara Przetocka, Stephen T. Durant, Josep V. Forment, Ismar Klebic, Myriam Siffert, Roebi de Bruijn, Arne N. Kousholt, Nicole A. Marti, Martina Dettwiler, Claus S. Sørensen, Jean-Christophe Tille, Manuela Undurraga, Intidhar Labidi-Galy, Massimo Lopes, Alessandro A. Sartori, Jos Jonkers, Sven Rottenberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs). In response to DNA damage, H2AX becomes phosphorylated on serine residue 139 (known as γH2AX), resulting in the recruitmen
Externí odkaz:
https://doaj.org/article/a6af7a0f6d3e43499e0bd7b907be1211
Autor:
Paola Francica, Merve Mutlu, Vincent A. Blomen, Catarina Oliveira, Zuzanna Nowicka, Anika Trenner, Nora M. Gerhards, Peter Bouwman, Elmer Stickel, Maarten L. Hekkelman, Lea Lingg, Ismar Klebic, Marieke van de Ven, Renske de Korte-Grimmerink, Denise Howald, Jos Jonkers, Alessandro A. Sartori, Wojciech Fendler, J. Ross Chapman, Thijn Brummelkamp, Sven Rottenberg
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108068- (2020)
Summary: Using genome-wide radiogenetic profiling, we functionally dissect vulnerabilities of cancer cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response, together with classical DNA damage response genes and me
Externí odkaz:
https://doaj.org/article/c1546da443224518b9a9ceeee619ab96
Autor:
Diego Dibitetto, Martin Liptay, Francesca Vivalda, Ewa Gogola, Hulya Dogan, Martín G. Fernández, Alexandra Duarte, Jonas A. Schmid, Stephen T. Durant, Josep V. Forment, Ismar Klebic, Myriam Siffert, Roebi de Bruijn, Arne N. Kousholt, Nicole A. Marti, Martina Dettwiler, Claus S. Sørensen, Massimo Lopes, Alessandro A. Sartori, Jos Jonkers, Sven Rottenberg
Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs)1,2. In response to DNA damage, H2AX becomes phosphorylated on serine residue 139 (known as γH2AX), resulting in the recruitment of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::175ac711ecfb0ec05959a4002e1d3ac8
https://doi.org/10.1101/2023.05.22.541781
https://doi.org/10.1101/2023.05.22.541781
Autor:
Carmen A, Widmer, Ismar, Klebic, Natalya, Domanitskaya, Morgane, Decollogny, Denise, Howald, Myriam, Siffert, Paul, Essers, Zuzanna, Nowicka, Nadine, Stokar-Regenscheit, Marieke, van de Ven, Renske, de Korte-Grimmerink, José A, Galván, Colin E J, Pritchard, Ivo J, Huijbers, Wojciech, Fendler, Conchita, Vens, Sven, Rottenberg
Publikováno v:
Cancer research communications. 2(10)
In recent years platinum (Pt) drugs have been found to be especially efficient to treat patients with cancers that lack a proper DNA damage response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b3ae48feead58acc9625a899980606f
https://pubmed.ncbi.nlm.nih.gov/36467895
https://pubmed.ncbi.nlm.nih.gov/36467895
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
Pt-drug treatment of polyclonal cell lines with wild type as well as Lrrc8a or Lrrc8d knockout alleles shows positive selection for knockout alleles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34a45b3be5737727d80de2f7b410462
https://doi.org/10.1158/2767-9764.22545348
https://doi.org/10.1158/2767-9764.22545348
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
In recent years, platinum (Pt) drugs have been found to be especially efficient to treat patients with cancers that lack a proper DNA damage response, for example, due to dysfunctional BRCA1. Despite this knowledge, we are still missing helpful marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f298b83d5f8eaac3e632f9259a7bf3b
https://doi.org/10.1158/2767-9764.c.6550914.v1
https://doi.org/10.1158/2767-9764.c.6550914.v1
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
gRNA oligos used for the generation of Lrrc8a or Lrrc8d-knockout cell lines, organoids and tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8fab8ff46482b5da388cda400e92e7
https://doi.org/10.1158/2767-9764.22545336
https://doi.org/10.1158/2767-9764.22545336