Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ismail Sergin"'
Autor:
Ismail Sergin, Trent D. Evans, Xiangyu Zhang, Somashubhra Bhattacharya, Carl J. Stokes, Eric Song, Sahl Ali, Babak Dehestani, Karyn B. Holloway, Paul S. Micevych, Ali Javaheri, Jan R. Crowley, Andrea Ballabio, Joel D. Schilling, Slava Epelman, Conrad C. Weihl, Abhinav Diwan, Daping Fan, Mohamed A. Zayed, Babak Razani
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
Dysfunction of autophagy in plaque macrophages aggravates atherosclerosis. Here the authors show that induction of macrophage autophagy–lysosomal biogenesis either genetically by overexpression of the master transcriptional regulator of this proces
Externí odkaz:
https://doaj.org/article/2386c202410647229c348496bc117d5b
Autor:
Shuilong Leng, Stephen Iwanowycz, Fatma Saaoud, Junfeng Wang, Yuzhen Wang, Ismail Sergin, Babak Razani, Daping Fan
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 1006-1016 (2016)
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy. In the present study, we aimed to examine whether UA enhances macrophage autophagy in the co
Externí odkaz:
https://doaj.org/article/b47f0e5e48bb4c19827374a69a619aa5
Autor:
Omar Kabbarah, Felipe de Sousa e Melo, Mark R. Lackner, Frederic de Sauvage, Teiko Sumiyoshi, Hartmut Koeppen, Xueping Qu, Elicia Penuel, Jeremy Burton, Rajesh Patel, Rachel Tam, Noelyn Kljavin, Doris Kim, Zora Modrusan, Christiaan Kljin, Ismail Sergin, Ling Huw, Robert Piskol
Purpose:Four consensus molecular subtypes (CMS1–4) of colorectal cancer were identified in primary tumors and found to be associated with distinctive biological features and clinical outcomes. Given that distant metastasis largely accounts for colo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1005ee9c6d84a55771ffa56e48df8e65
https://doi.org/10.1158/1078-0432.c.6527750
https://doi.org/10.1158/1078-0432.c.6527750
Autor:
Omar Kabbarah, Felipe de Sousa e Melo, Mark R. Lackner, Frederic de Sauvage, Teiko Sumiyoshi, Hartmut Koeppen, Xueping Qu, Elicia Penuel, Jeremy Burton, Rajesh Patel, Rachel Tam, Noelyn Kljavin, Doris Kim, Zora Modrusan, Christiaan Kljin, Ismail Sergin, Ling Huw, Robert Piskol
Supplementary Figures S1 - S7. Figure S1, Development and validation of a CRC-focused Nanostring panel and CMS classifier. Figure S2, Comparison of CRC Nanostring- and whole transcriptome-based classification of FFPE samples. Figure S3, Survival afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c4d4716383ea9979006064e258f4df
https://doi.org/10.1158/1078-0432.22470980.v1
https://doi.org/10.1158/1078-0432.22470980.v1
Autor:
Xiangyu Zhang, Trent Evans, Chen Sunny, Ismail Sergin, Se-jin Jeong, Astrid Rodriguez-Velez, Yu-sheng Yeh, Jeremiah Stitham, Arick Park, Babak Razani
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
The mechanistic target of rapamycin (mTOR) pathway is considered a key regulator of cellular proliferation, survival, metabolism, and degradation. Yet its role in atherosclerosis and in macrophages of the atherosclerotic plaque remains poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d375013ef90e205c1732a3f35c950a9
https://doi.org/10.1161/atvb.42.suppl_1.433
https://doi.org/10.1161/atvb.42.suppl_1.433
Autor:
Astrid Rodriguez-Velez, Slava Epelman, Xiangyu Zhang, Trent D. Evans, Se Jin Jeong, Eric Song, Abhinav Diwan, Joel D. Schilling, Jan R. Crowley, Babak Razani, Conrad C. Weihl, Nathan O. Stitziel, Irfan J. Lodhi, Divya Kapoor, Bettina Mittendorfer, Daping Fan, Karyn B. Holloway, Sunny Chen, Ismail Sergin
Publikováno v:
Nature metabolism
High protein diets are commonly utilized for weight loss, yet have been reported to raise cardiovascular risk. The mechanisms underlying this risk are unknown. Here, we show that dietary protein drives atherosclerosis and lesion complexity. Protein i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e87814ce8d26da4495d0e8af57ea041
https://pubmed.ncbi.nlm.nih.gov/32908252
https://pubmed.ncbi.nlm.nih.gov/32908252
Autor:
Ida Johansson, Jan Kristian Damås, Ismail Sergin, Babak Razani, Geir Bjørkøy, Trude Helen Flo, Eli Kjøbli, Jennifer Mildenberger
Publikováno v:
Autophagy
Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) have known anti-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9623da87ae32155a5736b24f5c406dd
http://europepmc.org/articles/PMC5640206
http://europepmc.org/articles/PMC5640206
Autor:
Jan R. Crowley, Eric Song, Conrad C. Weihl, Andrea Ballabio, Karyn B. Holloway, Babak Razani, Babak Dehestani, Carl J. Stokes, Sahl Ali, Paul S. Micevych, Slava Epelman, Abhinav Diwan, Daping Fan, Joel D. Schilling, Trent D. Evans, Xiangyu Zhang, Somashubhra Bhattacharya, Mohamed A. Zayed, Ali Javaheri, Ismail Sergin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
Nature Communications
Nature Communications
Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756f0a04a8be265de57642a624790b24
https://doaj.org/article/2386c202410647229c348496bc117d5b
https://doaj.org/article/2386c202410647229c348496bc117d5b
Publikováno v:
Journal of Biological Chemistry. 292:3637-3655
Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm. However, recent studies indicate that some GPCRs are also localized to various subcellular com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e8d0f1265d8fbd0544c7dc309c4d51
https://doi.org/10.1074/jbc.m116.757724
https://doi.org/10.1074/jbc.m116.757724
TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis
Publikováno v:
Autophagy. 14:724-726
In the atherosclerotic plaque, macrophages are the key catabolic workhorse responsible for clearing lipid and dead cell debris. To survive the highly proinflammatory and lipotoxic plaque environment, macrophages must adopt strategies for maintaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1117d1ccf96419664821b2f8aa0d4a
https://doi.org/10.1080/15548627.2018.1434373
https://doi.org/10.1080/15548627.2018.1434373