Výsledky vyhledávání - "Ismael Y Karkache"

Akademický článek

Phlpp1 Expression in Osteoblasts Plays a Modest Role in Bone Homeostasis

Autor: Ismael Y Karkache, David HH Molstad, Elizabeth Vu, Eric D Jensen, Elizabeth W Bradley

Publikováno v: JBMR Plus, Vol 7, Iss 12, Pp n/a-n/a (2023)

ABSTRACT Prior work demonstrated that Phlpp1 deficiency alters limb length and bone mass, but the cell types involved and requirement of Phlpp1 for this effect were unclear. To understand the function of Phlpp1 within bone‐forming osteoblasts, we c

Externí odkaz: https://doaj.org/article/34133360d66241849078011d4e521091

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Akademický článek

Phlpp1 is induced by estrogen in osteoclasts and its loss in Ctsk-expressing cells does not protect against ovariectomy-induced bone loss.

Autor: Marcelline K Hanson, Ismael Y Karkache, David H H Molstad, Andrew A Norton, Kim C Mansky, Elizabeth W Bradley

Publikováno v: PLoS ONE, Vol 16, Iss 6, p e0251732 (2021)

Prior studies demonstrated that deletion of the protein phosphatase Phlpp1 in Ctsk-Cre expressing cells enhances bone mass, characterized by diminished osteoclast activity and increased coupling to bone formation. Due to non-specific expression of Ct

Externí odkaz: https://doaj.org/article/a1676eb44dfb4341bb44d713ce62da0b

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Myeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice

Autor: Kim C. Mansky, Jeyaram R. Damodaran, Ismael Y. Karkache, David H. H. Molstad, Elizabeth W. Bradley

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9702, p 9702 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18

Prior work demonstrated that Phlpp1 deficiency alters trabecular bone mass and enhances M-CSF responsiveness, but the cell types and requirement of Phlpp1 for this effect were unclear. To understand the function of Phlpp1 within myeloid lineage cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa28d850fa8f00db34b1c961ccfeb387
https://www.mdpi.com/1422-0067/22/18/9702

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Myeloid Lineage Ablation of

Autor: Ismael Y, Karkache, Jeyaram R, Damodaran, David H H, Molstad, Kim C, Mansky, Elizabeth W, Bradley

Publikováno v: International Journal of Molecular Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9086d97d0cc7f68b000c2555061adcb5
https://pubmed.ncbi.nlm.nih.gov/34575866

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Phlpp1 is induced by estrogen in osteoclasts and its loss in Ctsk-expressing cells does not protect against ovariectomy-induced bone loss

Autor: Marcelline K. Hanson, David H. H. Molstad, Elizabeth W. Bradley, Kim C. Mansky, Andrew Norton, Ismael Y. Karkache

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0251732 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53ab543596cc5df80aaa95eb1c26006
https://pubmed.ncbi.nlm.nih.gov/34143773

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Serine/threonine phosphatases in osteoclastogenesis and bone resorption

Autor: Ismael Y. Karkache, Jeyaram R. Damodaran, Elizabeth W. Bradley, David H. H. Molstad

Publikováno v: Gene

Maintenance of optimal bone mass is controlled through the concerted functions of several cell types, including bone resorbing osteoclasts. Osteoclasts function to remove calcified tissue during developmental bone modeling, and degrade bone at sites

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb2b4f40b2d04584b12d8584725f2fa
https://doi.org/10.1016/j.gene.2020.145362

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