Výsledky vyhledávání - "Islets of Langerhans/drug effects/secretion"

Glucose and Cyclic AMP as Stimulators of Somatostatin and Insulin Secretion From the Isolated, Perfused Rat Pancreas: A Quantitative Study

Autor: Ralph E. Miller, Claes B. Wollheim, Albert E. Renold, Elisabeth R. Trimble, Pietro P G Gerber

Publikováno v: Diabetes, Vol. 30, No 1 (1981) pp. 40-4

The secretory responses of beta and delta cells were compared in the isolated, perfused, rat pancreas. Insulin release was stimulated 50-fold and somatostatin (SRIF) secretion twofold when the glucose concentration was increased from 100 mg/dl to 300

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578cfd99609ee54ae9dd2bd21793155a
https://doi.org/10.2337/diab.30.1.40

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Differential rates of release of newly synthesized and of stored insulin from pancreatic islets

Autor: Philippe A. Halban

Publikováno v: Endocrinology, Vol. 110, No 4 (1982) pp. 1183-1188

Rat pancreatic islets were maintained in tissue culture (8.3 mM glucose) for 3 days in the presence of [3H]leucine in order to label insulin stores. Alternatively, islets were labeled for 1 h at the end of a 3-day maintenance period in order to label

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d812a8282102f443238830605a9cc4b3
https://pubmed.ncbi.nlm.nih.gov/6174318

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Biphasic insulin release in rat islets of Langerhans and the role of Intracellular Ca++ stores

Autor: Eberhard G. Siegel, Masatoshi Kikuchi, Claes B. Wollheim, Albert E. Renold, Geoffrey W. G. Sharp

Publikováno v: Endocrinology, Vol. 105, No 4 (1979) pp. 1013-9

The role of extracellular Ca++ in the development of biphasic insulin release has been studied previously by using Verapamil to block the glucose-induced stimulation of Ca++ uptake. It was found that glucose-stimulated uptake of Ca++ from the extrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afc810d385a38dd2d91bb4df35e8380
https://pubmed.ncbi.nlm.nih.gov/383467

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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway

Autor: Christopher J. Rhodes, Philippe A. Halban

Publikováno v: The Journal of Cell Biology, Vol. 105, No 1 (1987) pp. 145-153
The Journal of Cell Biology

The pancreatic B cell has been used as a model to compare the release of newly synthesized prohormone/hormone with that of stored hormone. Secretion of newly synthesized proinsulin/insulin (labeled with [3H]leucine during a 5-min pulse) and stored to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6483a0c9478077cd1eace0dd4c3b3800
https://archive-ouverte.unige.ch/unige:8991

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