Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Islets of Langerhans/drug effects"'
Autor:
Subhash Kamath, Anthony G. Comuzzie, Stefano La Rosa, Eliana S. Di Cairano, Ana Maria Paez, Alberto O. Chavez, Francesca Casiraghi, Rodolfo Guardado-Mendoza, Paolo Fiorina, Ralph A. DeFronzo, Paul B. Higgins, Fausto Sessa, A.M. Davalli, Gregory A Abrahamian, Giuseppe Daniele, Livio Luzi, Carla Perego, Franco Folli, Amalia Gastaldelli, Francesco Andreozzi, Alessandro Marando, Giovanna Finzi, Patrice A. Frost, Glenn A. Halff, Raul A. Bastarrachea, Andrea Ricotti, Edward J. Dick, Teresa Vanessa Fiorentino
Publikováno v:
JCI insight, vol. 4, no. 20, pp. e93091
The glucagon-like peptide-1 receptor agonist exenatide improves glycemic control by several and not completely understood mechanisms. Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f072dd0108e820cfaf15ec060579022a
https://serval.unil.ch/resource/serval:BIB_893519A0D48A.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_893519A0D48A.P001/REF.pdf
Autor:
Andrej Babič, Hans-Paul Juretschke, Paolo Meda, Heiner Glombik, Nathalie Martine Stransky-Heilkron, Norbert Lange, Smaragda Lamprianou, Laurent Vinet, Celine Xayaphoummine, Anke M. Schulte, Marino A. Campo, Xavier Montet
Publikováno v:
Biomaterials
Biomaterials, Vol. 75 (2016) pp. 1-12
Biomaterials, Vol. 75 (2016) pp. 1-12
The monitoring of diabetes mellitus, as it develops and becomes clinically evident, remains a major challenge for diagnostic imaging in clinical practice. Here we present a novel approach to beta-cell imaging by targeting the sulphonylurea receptor s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80ba5b71f1ca3601d0b0eaab90bae79
https://doi.org/10.1016/j.biomaterials.2015.10.006
https://doi.org/10.1016/j.biomaterials.2015.10.006
Autor:
Marie-Jeanne Richard, Laurent Argaud, Sandrine Lablanche, Cécile Cottet-Rousselle, Thierry Berney, Pierre-Yves Benhamou, Camille Laporte, Eric Fontaine, Frédéric Lamarche
Publikováno v:
Biochimica et Biophysica Acta, Vol. 1847, No 6-7 (2015) pp. 629-639
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2015, 1847 (6-7), pp.629-39. ⟨10.1016/j.bbabio.2015.04.002⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2015, 1847 (6-7), pp.629-39. ⟨10.1016/j.bbabio.2015.04.002⟩
International audience; Deficit in oxygen and energetic substrates delivery is a key factor in islet loss during islet transplantation. Permeability transition pore (PTP) is a mitochondrial channel involved in cell death. We have studied the respecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284c70d7aa72f9100d0259f1d6147062
https://doi.org/10.1016/j.bbabio.2015.04.002
https://doi.org/10.1016/j.bbabio.2015.04.002
Autor:
Frédéric Ris, Jose Oberholzer, Giatgen A. Spinas, Helen I. Joller-Jemelka, Nurit Kaiser, Marc Y. Donath, Pavel Sergeev, Kathrin Maedler, Philippe A. Halban
Publikováno v:
Journal of Clinical Investigation, Vol. 110, No 6 (2002) pp. 851-860
In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic beta cells, causing impaired insulin secretion. IL-1beta is a proinflammatory cytokine acting during the autoimmune process of type 1 diabetes. IL-1beta inhibits b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688d54d567d48a8372791ef68a5760b7
https://doi.org/10.5167/uzh-208352
https://doi.org/10.5167/uzh-208352
Autor:
Sara Sdelci, Tibor Harkany, Keiryn L. Bennett, Kilian Huber, Patrick Collombat, Christian Honoré, Florian M. Pauler, Matthias Farlik, Ekaterine Berishvili, Monica Courtney, Igor Baburin, Stefan Kubicek, Nicole Schmitner, Jin Li, Steffen Hering, Peter Májek, Jacob Hecksher-Sørensen, Thierry Sulpice, Martin Distel, Robin A. Kimmel, Charles-Hugues Lardeau, Manuela Gridling, Johanna Klughammer, Camilla Ingvorsen, Alexey Stukalov, Christoph Bock, Andhira Vieira, François Briand, Giulio Superti-Furga, Roman A. Romanov, Thomas Frogne, Dirk Meyer, Caterina Sturtzel, Thomas Penz, Fabio Avolio, Katja Parapatics, Jacques Colinge, Andreas Spittler, Charlotte Barbieux, Tamara Casteels
Publikováno v:
Cell
Cell, Elsevier, 2017, 168 (1-2), pp.86-100.e15. ⟨10.1016/j.cell.2016.11.010⟩
Cell, Vol. 168, No 1-2 (2017) pp. 86-100.e15
Cell, Elsevier, 2017, 168 (1-2), pp.86-100.e15. ⟨10.1016/j.cell.2016.11.010⟩
Cell, Vol. 168, No 1-2 (2017) pp. 86-100.e15
Summary Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new insulin-producing cells from other cell types is a major aim of regenerative medicine. One promising approach is transdifferentiation of developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebb27a89e331313da6daa3b1b61b868
https://hal.umontpellier.fr/hal-02284911
https://hal.umontpellier.fr/hal-02284911
Autor:
Victor Pallarès, Santiago Garcia-Vallvé, Anna Ardévol, M. José Motilva, M. Teresa Blay, Pierre Maechler, Anna Castell-Auví, Lídia Cedó, Gerard Pujadas, Montserrat Pinent
Publikováno v:
Journal of Nutritional Biochemistry, Vol. 23, No 12 (2012) pp. 1565-72
The Journal of nutritional biochemistry
The Journal of nutritional biochemistry
Previous studies from our research group have suggested that procyanidins modify glycemia and insulinemia. The aim of this work was to evaluate the effects of procyanidins on β-cell functionality in a nonpathological system. Four groups of healthy r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a66716f5a5050e7df8d75cbb64b997f
https://doi.org/10.1016/j.jnutbio.2011.10.010
https://doi.org/10.1016/j.jnutbio.2011.10.010
Publikováno v:
Molecular and Cellular Proteomics, Vol. 11, No 8 (2012) pp. 244-54
Insulin secretory granules are β-cell vesicles dedicated to insulin processing, storage, and release. The secretion of insulin secretory granule content in response to an acute increase of glucose concentration is a highly regulated process allowing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c9bea3dfeb08089c7bfdee24513e52
https://doi.org/10.1074/mcp.m112.018051
https://doi.org/10.1074/mcp.m112.018051
Autor:
Lutgart Overbergh, Daniel Andrade Da Cunha, Wannes D'Hertog, Etienne Waelkens, Chantal Mathieu, Hannelie Korf, Miriam Cnop, T. Koike, Michael Maris
Publikováno v:
Journal of proteome research, 10 (8
High levels of fatty acids contribute to loss of functional beta cell mass in type 2 diabetes, in particular in combination with high glucose levels. The aim of this study was to elucidate the role of the unsaturated free fatty acid oleate in glucoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbab62695ffe68b0c9a87b2aa24f5c5
https://doi.org/10.1021/pr101290n
https://doi.org/10.1021/pr101290n
Autor:
Lotte Bjerre Knudsen, Juliet Emamaullee, Christian Toso, Wayne Truong, A M. J. Shapiro, Shaheed Merani
Publikováno v:
Endocrinology, Vol. 149, No 9 (2008) pp. 4322-4328
The current scarcity of high-quality deceased pancreas donors prevents widespread application of islet transplantation for treatment of labile type 1 diabetes mellitus. Opportunities for the improvement of current techniques include optimization of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90b87bb244f428387d32f7813305565
https://doi.org/10.1210/en.2008-0501
https://doi.org/10.1210/en.2008-0501
Autor:
Mogens Aalund, Mogens Kruhøffer, Claes B. Wollheim, Peter Hagedorn, Torben F. Ørntoft, Jørn Nerup, Regine Bergholdt, Jens Høiriis Nielsen, Allan E. Karlsen, Flemming Pociot, Haiyan Wang
Publikováno v:
University of Copenhagen
Genes and Immunity, Vol. 8, No 3 (2007) pp. 232-8
Bergholdt, R, Karlsen, A E, Hagedorn, P H, Aalund, M, Nielsen, J H, Kruhøffer, M, Wang, H, Wollheim, C B, Nerup, J & Pociot, F 2007, ' Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets ', Genes and Immunity, vol. 8, no. 3, pp. 232-238 . https://doi.org/10.1038/sj.gene.6364379
Genes and Immunity, Vol. 8, No 3 (2007) pp. 232-8
Bergholdt, R, Karlsen, A E, Hagedorn, P H, Aalund, M, Nielsen, J H, Kruhøffer, M, Wang, H, Wollheim, C B, Nerup, J & Pociot, F 2007, ' Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets ', Genes and Immunity, vol. 8, no. 3, pp. 232-238 . https://doi.org/10.1038/sj.gene.6364379
We recently finemapped a type 1 diabetes (T1D)-linked region on chromosome 21, indicating that one or more T1D-linked genes exist in this region with 33 annotated genes. In the current study, we have taken a novel approach using transcriptional profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3c37f06f5e2372f64d6120f4360da5
https://doi.org/10.1038/sj.gene.6364379
https://doi.org/10.1038/sj.gene.6364379