Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Autor: Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A. Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M ’t Hart, Ewan R. Pearson, Guy A. Rutter

Publikováno v: Slieker, R C, Donnelly, L A, Akalestou, E, Lopez-Noriega, L, Melhem, R, Güneş, A, Abou Azar, F, Efanov, A, Georgiadou, E, Muniangi-Muhitu, H, Sheikh, M, Giordano, G N, Åkerlund, M, Ahlqvist, E, Ali, A, Banasik, K, Brunak, S, Barovic, M, Bouland, G A, Burdet, F, Canouil, M, Dragan, I, Elders, P J M, Fernandez, C, Festa, A, Fitipaldi, H, Froguel, P, Gudmundsdottir, V, Gudnason, V, Gerl, M J, van der Heijden, A A, Jennings, L L, Hansen, M K, Kim, M, Leclerc, I, Klose, C, Kuznetsov, D, Mansour Aly, D, Mehl, F, Marek, D, Melander, O, Niknejad, A, Ottosson, F, Pavo, I, Duffin, K, Syed, S K, Shaw, J L, Cabrera, O, Pullen, T J, Simons, K, Solimena, M, Suvitaival, T, Wretlind, A, Rossing, P, Lyssenko, V, Legido Quigley, C, Groop, L, Thorens, B, Franks, P W, Lim, G E, Estall, J, Ibberson, M, Beulens, J W J, 't Hart, L M, Pearson, E R & Rutter, G A 2023, ' Identification of biomarkers for glycaemic deterioration in type 2 diabetes ', Nature Communications, vol. 14, 2533 . https://doi.org/10.1038/s41467-023-38148-7
Slieker, R C, Donnelly, L A, Akalestou, E, Lopez-Noriega, L, Melhem, R, Güneş, A, Abou Azar, F, Efanov, A, Georgiadou, E, Muniangi-Muhitu, H, Sheikh, M, Giordano, G N, Åkerlund, M, Ahlqvist, E, Ali, A, Banasik, K, Brunak, S R, Barovic, M, Bouland, G A, Burdet, F, Canouil, M, Dragan, I, Elders, P J M, Fernandez, C, Festa, A, Fitipaldi, H, Froguel, P, Gudmundsdottir, V, Gudnason, V, Gerl, M J, van der Heijden, A A, Jennings, L L, Hansen, M K, Kim, M, Leclerc, I, Klose, C, Kuznetsov, D, Mansour Aly, D, Mehl, F, Marek, D, Melander, O, Niknejad, A, Ottosson, F, Pavo, I, Duffin, K, Syed, S K, Shaw, J L, Cabrera, O, Pullen, T J, Simons, K, Solimena, M, Suvitaival, T, Wretlind, A, Rossing, P, Lyssenko, V, Legido Quigley, C, Groop, L, Thorens, B, Franks, P W, Lim, G E, Estall, J, Ibberson, M, Beulens, J W J, ’t Hart, L M, Pearson, E R & Rutter, G A 2023, ' Identification of biomarkers for glycaemic deterioration in type 2 diabetes ', Nature Communications, vol. 14, no. 1, 2533 . https://doi.org/10.1038/s41467-023-38148-7
Nature Communications, 14(1):2533. Nature Publishing Group UK

We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1654ea5cf5cf5976c8684f5b8cb7ed
https://curis.ku.dk/portal/da/publications/identification-of-biomarkers-for-glycaemic-deterioration-in-type-2-diabetes(32aaa1f9-fa85-4d91-83f7-6715b74bca9e).html

Normal Pregnancy-Induced Islet Beta Cell Proliferation in Mouse Models That Are Deficient in Serotonin-Signaling

Autor: Lotte Goyvaerts, Anica Schraenen, Katleen Lemaire, Peter in’t Veld, Ilse Smolders, Luc Maroteaux, Frans Schuit

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15816

During mouse pregnancy placental lactogens stimulate prolactin receptors on pancreatic islet beta cells to induce expression of the tryptophan hydroxylase Tph1, resulting in the synthesis and secretion of serotonin. Presently, the functional relevanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfd1eebe58634988f955cb0b8a472ff
https://doi.org/10.3390/ijms232415816

Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats

Autor: Kaare V. Grunddal, Samuel A. J. Trammell, Cecilie Bæch-Laursen, Daniel B. Andersen, Stella F. S. Xu, Helle Andersen, Matthew P. Gillum, Seyed M. Ghiasi, Ivana Novak, Björn Tyrberg, Chien Li, Mette M. Rosenkilde, Bolette Hartmann, Jens J. Holst, Rune E. Kuhre

Publikováno v: Grunddal, K V, Trammell, S A J, Bæch-Laursen, C, Andersen, D B, Xu, S F S, Andersen, H, Gillum, M P, Ghiasi, S M, Novak, I, Tyrberg, B, Li, C, Rosenkilde, M M, Hartmann, B, Holst, J J & Kuhre, R E 2022, ' Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats ', Diabetologia, vol. 65, no. 6, pp. 1018-1031 . https://doi.org/10.1007/s00125-022-05675-9
Grunddal, K V, Trammell, S A J, Bæch-Laursen, C, Andersen, D B, Xu, S F S, Andersen, H, Gillum, M P, Ghiasi, S M, Novak, I, Tyrberg, B, Li, C, Rosenkilde, M M, Hartmann, B, Holst, J J & Kuhre, R E 2022, ' Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats ', Diabetologia, vol. 65, pp. 1018–1031 . https://doi.org/10.1007/s00125-022-05675-9

Aim/hypothesis Urocortin-3 (UCN3) is a glucoregulatory peptide produced in the gut and pancreatic islets. The aim of this study was to clarify the acute effects of UCN3 on glucose regulation following an oral glucose challenge and to investigate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658a8f06433bf32dc32bc8cf4b917233
https://pubmed.ncbi.nlm.nih.gov/35325259

Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets

Autor: Julien Gaitan, Domenico Bosco, Eléonore Bertin, Fanny Lebreton, Daniel Cattaert, Bogdan Catargi, Sylvie Renaud, Matthieu Raoux, Emilie Puginier, Sandra Oucherif, Jochen Lang, Antoine Pirog, Manon Jaffredo

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2021, 70 (4), pp.878-888. ⟨10.2337/db20-0214⟩
Diabetes, Vol. 70, No 4 (2021) pp. 878-888

Biphasic secretion is an autonomous feature of many endocrine micro-organs to fulfill physiological demands. The biphasic activity of islet β-cells maintains glucose homeostasis and is altered in type 2 diabetes. Nevertheless, underlying cellular or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593d030e72579c59337b5397faae35ae
https://hal-cnrs.archives-ouvertes.fr/hal-03366240

Islets for Research: Nothing Is Perfect, but We Can Do Better

Autor: Olle Korsgren, Raffaella Melzi, Marie Karlsson, Valery Gmyr, Julie Kerr-Conte, Lorenzo Piemonti, Vanessa Lavallard, Rita Nano, Alessia Mercalli, François Pattou, Domenico Bosco, Thierry Berney

Publikováno v: Diabetes, Vol. 68, No 8 (2019) pp. 1541-1543
Diabetes

In December 2018, Diabetes and Diabetologia began requiring authors of papers reporting data obtained from studies on human islets to report critical characteristics of the human islets used for research. The islet community was asked to provide feed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef58b1bab02302430dfbce3f032411e8
https://doi.org/10.2337/db19-0367