Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Islets of Langerhan"'
Autor:
Gérard Cros, Morgane Bayle, Jérémie Neasta, Catherine Oiry, Sylvie Peraldi-Roux, Guillaume Gautheron
Publikováno v:
Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2021, ⟨10.1111/fcp.12722⟩
Fundamental and Clinical Pharmacology, Wiley, In press, ⟨10.1111/fcp.12722⟩
Fundamental and Clinical Pharmacology, Wiley, 2021, ⟨10.1111/fcp.12722⟩
Fundamental and Clinical Pharmacology, Wiley, In press, ⟨10.1111/fcp.12722⟩
Background The hormone ghrelin is the endogenous agonist of the G-protein coupled receptor (GPCR) termed growth-hormone secretagogue receptor (GHSR). Ghrelin inhibits glucose-stimulated insulin secretion by activating pancreatic GHSR. Recently, Liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2760051bff0163caf16961e93f80a5e
https://hal.archives-ouvertes.fr/hal-03370769
https://hal.archives-ouvertes.fr/hal-03370769
Autor:
Antonio La Cava, Concetta Ferretti
Publikováno v:
Autoimmunity Reviews. 15:236-241
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and multifactorial and involves a genetic susceptibility that predisposes to abnormal immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ecc8c95337929cf94537a8fff26a34
https://doi.org/10.1016/j.autrev.2015.11.008
https://doi.org/10.1016/j.autrev.2015.11.008
Autor:
Rita Nano, Riccardo C. Bonadonna, Lorenzo Piemonti, Raffaella Melzi, Alessia Mercalli, Gianpaolo Balzano, Marina Scavini
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Islet volume and endocrine pancreas architecture (islet size distribution) may be independent determinants of β-cell function. Furthermore, the accuracy of homeostatic model assessment (HOMA) indexes in predicting β-cell mass has never been assesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0351e1b4fb154cc1aaf308be4da505
https://doi.org/10.3727/096368915x688498
https://doi.org/10.3727/096368915x688498
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 143, p 143 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Metabolic disorders such as obesity and type 2 diabetes (T2D) are considered the major risk factors for the development of cardiovascular diseases (CVD). Although the pathological mechanisms underlying the mutual development of obesity and T2D are di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3375abfc25d172f22ecd7199d57d2f22
https://doi.org/10.3390/ijms22010143
https://doi.org/10.3390/ijms22010143
Autor:
Cristina Morsiani, Tatiana Jofra, Manuela Battaglia, Roberta Di Fonte, Georgia Fousteri, Nicola Gagliani, Angela Stabilini
Publikováno v:
Diabetologia. 58:1319-1328
Aims/hypothesis: Protein tyrosine phosphatase non-receptor 22 (PTPN22) plays a central role in T cell, B cell and innate immune cell signalling. A genetic variation in Ptpn22 is considered a major risk factor for the development of type 1 diabetes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bdb46180a50e406c62ef09a62bca02
https://doi.org/10.1007/s00125-015-3540-9
https://doi.org/10.1007/s00125-015-3540-9
Human Pancreatic Islet Production: From Research Protocols to Standardized Multicenter Manufacturing
Autor:
Federico Bertuzzi, Luciano De Carlis
Publikováno v:
Diabetes. 65:3243-3245
Transient function following human pancreatic islet allotransplantation in a subject with type 1 diabetes was first reported over 25 years ago (1). Since then, clinical outcomes have been progressively improving, and nowadays islet transplantation re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9a43e2198b2ecef66a54eaecfee79e
https://doi.org/10.2337/dbi16-0045
https://doi.org/10.2337/dbi16-0045
Autor:
Rohit N. Kulkarni, Alfredo Pontecorvi, Gian Pio Sorice, Andrea Giaccari, Gennaro Clemente, Jens J. Holst, Giovanna Muscogiuri, Jiang Hu, Teresa Mezza
Publikováno v:
Diabetes
Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance. In addition to its effects on skeletal muscle, liver, and adipose tissue metabolism, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1145e717731d2908b39e2d0b6181cbe
http://europepmc.org/articles/PMC3931397
http://europepmc.org/articles/PMC3931397
Autor:
Luca Ulianich, Giuseppe Nicolardi, Dario Domenico Lofrumento, Francesco Beguinot, Claudia Miele, Antonella Sonia Treglia, Corrado Garbi, Cecilia Nigro, B. Di Jeso, Luca Parrillo, Angela Lombardi
Publikováno v:
Diabetologia (Berl.) (2012).
info:cnr-pdr/source/autori:Lombardi A, Ulianich L, Treglia AS, Nigro C, Parrillo L, Lofrumento DD, Nicolardi G, Garbi C, Beguinot F, Miele C, Di Jeso B. Source/titolo:Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1%2F2-mediated signal transmission pathway./doi:/rivista:Diabetologia (Berl.)/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume
info:cnr-pdr/source/autori:Lombardi A, Ulianich L, Treglia AS, Nigro C, Parrillo L, Lofrumento DD, Nicolardi G, Garbi C, Beguinot F, Miele C, Di Jeso B. Source/titolo:Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1%2F2-mediated signal transmission pathway./doi:/rivista:Diabetologia (Berl.)/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume
AIMS/HYPOTHESIS: Beta cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (decline of glucose-stimulated insulin secretion, downregulation of specific gene expression). Apoptosis and dysfunction are caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634db53341c8f505f7cacf6e724ed465
https://doi.org/10.1007/s00125-011-2315-1
https://doi.org/10.1007/s00125-011-2315-1
Autor:
Samy S. Iskandar, Luca Urbani, Mario Enrique Alvarez Fallas, Panagiotis Maghsoudlou, Emmanuel C. Opara, Cristina M. Furdui, Andrea Peloso, Lorenzo Piemonti, Shay Soker, Giuseppe Orlando, Valeria Sordi, Jeffrey Rogers, Robert J. Stratta, Paolo Cravedi, Carolina Purroy, Antonio Citro, Sivanandane Sittadjody, Paolo De Coppi, Guoguang Niu, Ravi Katari, Joao Paulo Zambon, Alan C. Farney, John P. McQuilling
Publikováno v:
Annals of surgery. 264(1)
OBJECTIVES: Our study aims at producing acellular extracellular matrix scaffolds from the human pancreas (hpaECMs) as a first critical step toward the production of a new-generation, fully human-derived bioartificial endocrine pancreas. In this bioar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e313682715da277b60ab2e375df1afdf
https://pubmed.ncbi.nlm.nih.gov/26649588
https://pubmed.ncbi.nlm.nih.gov/26649588
Autor:
Alessia Mercalli, Marie Karlsson, Rita Nano, Lorenzo Piemonti, Domenico Bosco, François Pattou, Raffaella Melzi, Julie Kerr-Conte, Olle Korsgren, Albert Hwa, Thierry Berney, Rimed Ezzouaoui, Solange Charvier
Publikováno v:
Diabetologia, Vol. 58, No 5 (2015) pp. 1138-40
To the Editor: Single-centre or collaborative efforts have been made to provide human pancreatic islets for use in basic science research. These include the Integrated Islet Distribution Program in the USA [1], the Human Islet Distribution Program fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313bc78226db95854fa0deed1fb51f5e
https://pubmed.ncbi.nlm.nih.gov/25697163
https://pubmed.ncbi.nlm.nih.gov/25697163