Zobrazeno 1 - 10
of 346
pro vyhledávání: '"Islet Studies"'
Autor:
Diti Chatterjee Bhowmick, Arianne Aslamy, Supriyo Bhattacharya, Eunjin Oh, Miwon Ahn, Debbie C. Thurmond
Publikováno v:
Diabetes
Double C2 Domain Β (DOC2b) protein is required for glucose-stimulated insulin secretion (GSIS) in β-cells, the underlying mechanism of which remains unresolved. Our biochemical analysis using primary human islets, human and rodent clonal β-cells r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74facfba2101ed3fb4483ebe259590f5
https://doi.org/10.2337/db21-0681
https://doi.org/10.2337/db21-0681
Autor:
Raghavendra G. Mirmira, Edward Simpson, Farooq Syed, Yunlong Liu, Chih-Chun Lee, Wenting Wu, Chuanpeng Dong, Garrick Chang, Jing Liu, Carmella Evans-Molina, Clayton Seitz, Decio L. Eizirik
Publikováno v:
Diabetes
Alternative splicing (AS) within the β-cell has been proposed as one potential pathway that may exacerbate autoimmunity and unveil novel immunogenic epitopes in type 1 diabetes (T1D). We used a computational strategy to prioritize pathogenic splicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9564708819da5d37f5baeb47b0417359
https://doi.org/10.2337/db20-0847
https://doi.org/10.2337/db20-0847
Autor:
Khalil Bouyakdan, Cindy Baldwin, Scott A. Campbell, Maureen Gannon, Thierry Alquier, Vincent Poitout, Nathalie Jouvet, Jennifer L. Estall, Shannon E. Townsend
Publikováno v:
Diabetes
Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects are pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8411cb5388bccac9f8e854d716a3e775
https://doi.org/10.2337/db21-0147
https://doi.org/10.2337/db21-0147
Autor:
Patrick E. MacDonald, Austin Bautista, Ying Wayne Wang, Jean Buteau, Mourad Ferdaoussi, Aliya F. Spigelman, Sophie L. Lewandowski, Matthew J. Merrins, Tamadher A. Alghamdi, Yaxing Jin, Nancy Smith, Haopeng Lin, Jocelyn E. Manning Fox, Kunimasa Suzuki
Publikováno v:
Diabetes
SUMOylation reduces oxidative stress and preserves islet mass at the expense of robust insulin secretion. To investigate a role for the deSUMOylating enzyme sentrin-specific protease 1 (SENP1) following metabolic stress, we put pancreas/gut-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fa3f211ce7f8f62af7fea9bc1a1e75
https://doi.org/10.2337/db20-1235
https://doi.org/10.2337/db20-1235
Autor:
Katherine E. Santostefano, Fiona M. Docherty, Shane P.M. Williams, JaeAnn M. Dwulet, Maria S. Hansen, Richard K.P. Benninger, Kent Riemondy, Holger A. Russ, Ali H. Shilleh, Roberto Castro-Gutierrez, Taylor M. Triolo, Mark A. Wallet, Lucas H. Armitage, Clayton E. Mathews
Publikováno v:
Diabetes
Stem cell–derived β-like cells (sBC) carry the promise of providing an abundant source of insulin-producing cells for use in cell replacement therapy for patients with diabetes, potentially allowing widespread implementation of a practical cure. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed58ff46388f413c2aeedd1b0851524
https://doi.org/10.2337/db20-0873
https://doi.org/10.2337/db20-0873
Publikováno v:
Diabetes, vol 71, iss 7
Diabetes
Diabetes
In obesity, increased mitochondrial metabolism with the accumulation of oxidative stress leads to mitochondrial damage and β-cell dysfunction. In particular, β-cells express antioxidant enzymes at relatively low levels and are highly vulnerable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8a624d97f032b89613550d5c9c12e1
https://escholarship.org/uc/item/0kz0c5dw
https://escholarship.org/uc/item/0kz0c5dw
Autor:
Angela Criscimanna, Nada Mohamed, George K. Gittes, Uylissa A. Rodriguez, Jing Hu, Farzad Esni, Krishna Prasadan, Christina P. Martins, Mairobys Socorro
Publikováno v:
Diabetes
In contrast to the skin and the gut, where somatic stem cells and their niche are well characterized, a definitive pancreatic multipotent cell population in the adult pancreas has yet to be revealed. Of particular interest is whether such cells may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cddaa803e99b8674345ef48069241a1
https://doi.org/10.2337/db20-1059
https://doi.org/10.2337/db20-1059
Publikováno v:
Diabetes
Enrichment of human islets with syntaxin 4 (STX4) improves functional β-cell mass through a nuclear factor-κB (NF-κB)–dependent mechanism. However, the detailed mechanisms underlying the protective effect of STX4 are unknown. For determination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe490e2e99adf1cdeed806541c5e628
https://doi.org/10.2337/db20-0868
https://doi.org/10.2337/db20-0868
Autor:
Maureen Gannon, Alexis U. Oguh, Xiaogdong Zhu, Morgan A. Gingerich, Doris A. Stoffers, Scott A. Soleimanpour
Publikováno v:
Diabetes
Current evidence indicates that proliferating β-cells express lower levels of some functional cell identity genes, suggesting that proliferating cells are not optimally functional. Pdx1 is important for β-cell specification, function, and prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e76a2dc96aab428252ea5d27edfbda3
https://doi.org/10.2337/db20-0599
https://doi.org/10.2337/db20-0599
Autor:
Anne-Laure Castell, Alexis Vivoli, Trevor S. Tippetts, Isabelle Robillard Frayne, Zuraya Elisa Angeles, Valentine S. Moullé, Scott A. Campbell, Matthieu Ruiz, Julien Ghislain, Christine Des Rosiers, William L. Holland, Scott A. Summers, Vincent Poitout
Publikováno v:
Diabetes
Fatty acid (FA) signaling contributes to β-cell mass expansion in response to nutrient excess, but the underlying mechanisms are poorly understood. In the presence of elevated glucose, FA metabolism is shifted toward synthesis of complex lipids, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f835ed26cf03481d7214091f674b12e
https://doi.org/10.2337/figshare.19337828
https://doi.org/10.2337/figshare.19337828