Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour.

Autor: Tyson HR; Biomedicine Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Harrison DJ; Biomedicine Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Higgs MJ; Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom., Isles AR; Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom., John RM; Biomedicine Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2024 Mar 26; Vol. 18, pp. 1374781. Date of Electronic Publication: 2024 Mar 26 (Print Publication: 2024).

The parenting hub of the hypothalamus is a focus of imprinted gene action.

Autor: Higgs MJ; Behavioural Genetics Group, Centre for Neuropsychiatric, Genetics and Genomics, Neuroscience and Mental Health Innovation Institute, Cardiff University, Cardiff, United Kingdom., Webberley AE; Behavioural Genetics Group, Centre for Neuropsychiatric, Genetics and Genomics, Neuroscience and Mental Health Innovation Institute, Cardiff University, Cardiff, United Kingdom., Allan AJ; The Mary Lyon Centre, MRC Harwell, Didcot, United Kingdom., Talat M; The Mary Lyon Centre, MRC Harwell, Didcot, United Kingdom., John RM; School of Biosciences, Cardiff University, Cardiff, United Kingdom., Isles AR; Behavioural Genetics Group, Centre for Neuropsychiatric, Genetics and Genomics, Neuroscience and Mental Health Innovation Institute, Cardiff University, Cardiff, United Kingdom.

Publikováno v: PLoS genetics [PLoS Genet] 2023 Oct 19; Vol. 19 (10), pp. e1010961. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).

NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia.

Autor: Alsaqati M; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK.; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences (DPMCN), School of Medicine, Cardiff University, Cardiff, UK.; School of Pharmacy, KGVI Building, Newcastle University, Newcastle Upon Tyne, NE1 4LF, UK., Davis BA; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK.; Lieber Institute for Brain Development, Johns Hopkins Medical Campus & Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wood J; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK.; School of Bioscience, The Sir Martin Evans Building, Museum Ave, Cardiff, CF10 3AX, UK., Jones MM; School of Bioscience, The Sir Martin Evans Building, Museum Ave, Cardiff, CF10 3AX, UK., Jones L; School of Bioscience, The Sir Martin Evans Building, Museum Ave, Cardiff, CF10 3AX, UK., Westwood A; School of Bioscience, The Sir Martin Evans Building, Museum Ave, Cardiff, CF10 3AX, UK., Petter O; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK., Isles AR; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK.; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences (DPMCN), School of Medicine, Cardiff University, Cardiff, UK., Linden D; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands., Van den Bree M; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK.; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences (DPMCN), School of Medicine, Cardiff University, Cardiff, UK., Owen M; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK.; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences (DPMCN), School of Medicine, Cardiff University, Cardiff, UK., Hall J; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK.; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences (DPMCN), School of Medicine, Cardiff University, Cardiff, UK., Harwood AJ; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK. harwoodaj@cardiff.ac.uk.; School of Bioscience, The Sir Martin Evans Building, Museum Ave, Cardiff, CF10 3AX, UK. harwoodaj@cardiff.ac.uk.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2022 Oct 10; Vol. 12 (1), pp. 438. Date of Electronic Publication: 2022 Oct 10.

The contribution of imprinted genes to neurodevelopmental and neuropsychiatric disorders.

Autor: Isles AR; MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK. IslesAR1@cardiff.ac.uk.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2022 May 21; Vol. 12 (1), pp. 210. Date of Electronic Publication: 2022 May 21.

Maternal care boosted by paternal imprinting in mammals

Autor: Creeth, HDJ, McNamara, GI, Tunster, SJ, Boque-Sastre, R, Allen, B, Sumption, L, Eddy, JB, Isles, AR, John, RM

Publikováno v: PLoS Biology
PLoS Biology, Vol 16, Iss 7, p e2006599 (2018)

In mammals, mothers are the primary caregiver, programmed, in part, by hormones produced during pregnancy. High-quality maternal care is essential for the survival and lifelong health of offspring. We previously showed that the paternally silenced im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c3f403fe4dbc89e864469dafeac4fc
http://europepmc.org/articles/PMC6067684