Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Islam R. Younis"'
Autor:
Islam R. Younis, Brian J. Kirby, Andrew N. Billin, Deqing Xiao, Qinghua Song, Timothy R. Watkins, Ahmed A. Othman
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 536-547 (2023)
Abstract Cilofexor is a nonsteroidal farnesoid X receptor (FXR) agonist being evaluated for treatment of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work characterized the pharmacokinetics, pharmacodynamic, safe
Externí odkaz:
https://doaj.org/article/69d9d611a3b5404a88365bc742848b86
Autor:
Elijah Weber, Islam R. Younis, Cara Nelson, Dora Ding, Ann Qin, Deqing Xiao, Timothy R. Watkins, Ahmed A. Othman
Publikováno v:
The Journal of Clinical Pharmacology. 63:560-568
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:1088-1097
Coadministration with acid-reducing agents (ARAs), including proton pump inhibitors (PPIs), histamine H
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:635-642
Characterizing interactions between new molecular entities (NMEs) and drug transporters is a critical element of drug development that helps in assessing potential transporter-based drug-drug interactions (DDIs). However, not all NME new drug applica
Autor:
Islam R. Younis, Chia‐Hsiang Hsueh, Cara Nelson, Andrew N. Billin, Mun Sang Yue, Deqing Xiao, Timothy R. Watkins, Ahmed A. Othman
Publikováno v:
The Journal of Clinical Pharmacology.
Publikováno v:
The Journal of Clinical Pharmacology. 62
There are more than 7000 rare diseases affecting approximately 30 million people in the United States. More than 90% of these diseases lack approved therapies. Several challenges face the development of "orphan drugs", such as the small populations o
Autor:
Elizabeth A. Lakota, Islam R. Younis, Donna A. Volpe, Vikram Patel, Yun Xu, Chandra Sahajwalla
Publikováno v:
The Journal of Clinical Pharmacology. 59:1035-1043
Different views appear in the literature on the extent of specific cytochrome P450 (CYP) involvement in methadone metabolism. The aim of this work is to leverage knowledge from drug-drug interaction (DDI) studies in new drug applications between meth
Autor:
Aimee C. Hodowanec, Islam R. Younis, Takashi E. Komatsu, Mario R Sampson, Andreas Pikis, Julian J. O'Rear, Mary E. Singer
Publikováno v:
The Journal of Clinical Pharmacology. 59:784-798
This review summarizes the significant impact of cytomegalovirus (CMV) infection on solid organ and hematopoietic stem cell transplant recipients. A discussion of the various CMV prevention and treatment strategies is provided, including a detailed d
Autor:
Mehul Mehta, Tiffany Farchione, Islam R. Younis, Mitchell V. Mathis, Hao Zhu, Mathangi Gopalakrishnan, Ramana S. Uppoor
Publikováno v:
JAMA Psychiatry
Importance Facilitating the development of safe and effective medications for schizophrenia is a public health imperative. Objectives To evaluate the association of shortening randomized clinical trial (RCT) duration with the modification of the Posi
Autor:
Mehul Mehta, Yaning Wang, Mathangi Gopalakrishnan, Ramana S. Uppoor, Mitchell V. Mathis, Hao Zhu, Islam R. Younis, Tiffany Farchione, Shamir N. Kalaria
Publikováno v:
Journal of clinical pharmacologyReferences. 60(7)
Despite agreement that early-onset schizophrenia is continuous with the adult-onset form, quantitative relationships between antipsychotic exposure and clinical response are relatively unexplored in adolescents, compared to adults. Clinical efficacy